Cargando…

‘Magnesium’-the master cation-as a drug—possibilities and evidences

Magnesium (Mg(2+)) is the 2nd most abundant intracellular cation, which participates in various enzymatic reactions; there by regulating vital biological functions. Magnesium (Mg(2+)) can regulate several cations, including sodium, potassium, and calcium; it consequently maintains physiological func...

Descripción completa

Detalles Bibliográficos
Autores principales: Mathew, Aparna Ann, Panonnummal, Rajitha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8249833/
https://www.ncbi.nlm.nih.gov/pubmed/34213669
http://dx.doi.org/10.1007/s10534-021-00328-7
_version_ 1783716982254731264
author Mathew, Aparna Ann
Panonnummal, Rajitha
author_facet Mathew, Aparna Ann
Panonnummal, Rajitha
author_sort Mathew, Aparna Ann
collection PubMed
description Magnesium (Mg(2+)) is the 2nd most abundant intracellular cation, which participates in various enzymatic reactions; there by regulating vital biological functions. Magnesium (Mg(2+)) can regulate several cations, including sodium, potassium, and calcium; it consequently maintains physiological functions like impulse conduction, blood pressure, heart rhythm, and muscle contraction. But, it doesn’t get much attention in account with its functions, making it a “Forgotten cation”. Like other cations, maintenance of the normal physiological level of Mg(2+) is important. Its deficiency is associated with various diseases, which point out to the importance of Mg(2+) as a drug. The roles of Mg(2+) such as natural calcium antagonist, glutamate NMDA receptor blocker, vasodilator, antioxidant and anti-inflammatory agent are responsible for its therapeutic benefits. Various salts of Mg(2+) are currently in clinical use, but their application is limited. This review collates all the possible mechanisms behind the behavior of magnesium as a drug at different disease conditions with clinical shreds of evidence.
format Online
Article
Text
id pubmed-8249833
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Springer Netherlands
record_format MEDLINE/PubMed
spelling pubmed-82498332021-07-02 ‘Magnesium’-the master cation-as a drug—possibilities and evidences Mathew, Aparna Ann Panonnummal, Rajitha Biometals Article Magnesium (Mg(2+)) is the 2nd most abundant intracellular cation, which participates in various enzymatic reactions; there by regulating vital biological functions. Magnesium (Mg(2+)) can regulate several cations, including sodium, potassium, and calcium; it consequently maintains physiological functions like impulse conduction, blood pressure, heart rhythm, and muscle contraction. But, it doesn’t get much attention in account with its functions, making it a “Forgotten cation”. Like other cations, maintenance of the normal physiological level of Mg(2+) is important. Its deficiency is associated with various diseases, which point out to the importance of Mg(2+) as a drug. The roles of Mg(2+) such as natural calcium antagonist, glutamate NMDA receptor blocker, vasodilator, antioxidant and anti-inflammatory agent are responsible for its therapeutic benefits. Various salts of Mg(2+) are currently in clinical use, but their application is limited. This review collates all the possible mechanisms behind the behavior of magnesium as a drug at different disease conditions with clinical shreds of evidence. Springer Netherlands 2021-07-02 2021 /pmc/articles/PMC8249833/ /pubmed/34213669 http://dx.doi.org/10.1007/s10534-021-00328-7 Text en © The Author(s), under exclusive licence to Springer Nature B.V. 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Mathew, Aparna Ann
Panonnummal, Rajitha
‘Magnesium’-the master cation-as a drug—possibilities and evidences
title ‘Magnesium’-the master cation-as a drug—possibilities and evidences
title_full ‘Magnesium’-the master cation-as a drug—possibilities and evidences
title_fullStr ‘Magnesium’-the master cation-as a drug—possibilities and evidences
title_full_unstemmed ‘Magnesium’-the master cation-as a drug—possibilities and evidences
title_short ‘Magnesium’-the master cation-as a drug—possibilities and evidences
title_sort ‘magnesium’-the master cation-as a drug—possibilities and evidences
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8249833/
https://www.ncbi.nlm.nih.gov/pubmed/34213669
http://dx.doi.org/10.1007/s10534-021-00328-7
work_keys_str_mv AT mathewaparnaann magnesiumthemastercationasadrugpossibilitiesandevidences
AT panonnummalrajitha magnesiumthemastercationasadrugpossibilitiesandevidences