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‘Magnesium’-the master cation-as a drug—possibilities and evidences
Magnesium (Mg(2+)) is the 2nd most abundant intracellular cation, which participates in various enzymatic reactions; there by regulating vital biological functions. Magnesium (Mg(2+)) can regulate several cations, including sodium, potassium, and calcium; it consequently maintains physiological func...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Netherlands
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8249833/ https://www.ncbi.nlm.nih.gov/pubmed/34213669 http://dx.doi.org/10.1007/s10534-021-00328-7 |
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author | Mathew, Aparna Ann Panonnummal, Rajitha |
author_facet | Mathew, Aparna Ann Panonnummal, Rajitha |
author_sort | Mathew, Aparna Ann |
collection | PubMed |
description | Magnesium (Mg(2+)) is the 2nd most abundant intracellular cation, which participates in various enzymatic reactions; there by regulating vital biological functions. Magnesium (Mg(2+)) can regulate several cations, including sodium, potassium, and calcium; it consequently maintains physiological functions like impulse conduction, blood pressure, heart rhythm, and muscle contraction. But, it doesn’t get much attention in account with its functions, making it a “Forgotten cation”. Like other cations, maintenance of the normal physiological level of Mg(2+) is important. Its deficiency is associated with various diseases, which point out to the importance of Mg(2+) as a drug. The roles of Mg(2+) such as natural calcium antagonist, glutamate NMDA receptor blocker, vasodilator, antioxidant and anti-inflammatory agent are responsible for its therapeutic benefits. Various salts of Mg(2+) are currently in clinical use, but their application is limited. This review collates all the possible mechanisms behind the behavior of magnesium as a drug at different disease conditions with clinical shreds of evidence. |
format | Online Article Text |
id | pubmed-8249833 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Netherlands |
record_format | MEDLINE/PubMed |
spelling | pubmed-82498332021-07-02 ‘Magnesium’-the master cation-as a drug—possibilities and evidences Mathew, Aparna Ann Panonnummal, Rajitha Biometals Article Magnesium (Mg(2+)) is the 2nd most abundant intracellular cation, which participates in various enzymatic reactions; there by regulating vital biological functions. Magnesium (Mg(2+)) can regulate several cations, including sodium, potassium, and calcium; it consequently maintains physiological functions like impulse conduction, blood pressure, heart rhythm, and muscle contraction. But, it doesn’t get much attention in account with its functions, making it a “Forgotten cation”. Like other cations, maintenance of the normal physiological level of Mg(2+) is important. Its deficiency is associated with various diseases, which point out to the importance of Mg(2+) as a drug. The roles of Mg(2+) such as natural calcium antagonist, glutamate NMDA receptor blocker, vasodilator, antioxidant and anti-inflammatory agent are responsible for its therapeutic benefits. Various salts of Mg(2+) are currently in clinical use, but their application is limited. This review collates all the possible mechanisms behind the behavior of magnesium as a drug at different disease conditions with clinical shreds of evidence. Springer Netherlands 2021-07-02 2021 /pmc/articles/PMC8249833/ /pubmed/34213669 http://dx.doi.org/10.1007/s10534-021-00328-7 Text en © The Author(s), under exclusive licence to Springer Nature B.V. 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Article Mathew, Aparna Ann Panonnummal, Rajitha ‘Magnesium’-the master cation-as a drug—possibilities and evidences |
title | ‘Magnesium’-the master cation-as a drug—possibilities and evidences |
title_full | ‘Magnesium’-the master cation-as a drug—possibilities and evidences |
title_fullStr | ‘Magnesium’-the master cation-as a drug—possibilities and evidences |
title_full_unstemmed | ‘Magnesium’-the master cation-as a drug—possibilities and evidences |
title_short | ‘Magnesium’-the master cation-as a drug—possibilities and evidences |
title_sort | ‘magnesium’-the master cation-as a drug—possibilities and evidences |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8249833/ https://www.ncbi.nlm.nih.gov/pubmed/34213669 http://dx.doi.org/10.1007/s10534-021-00328-7 |
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