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ZYG11A Is Expressed in Epithelial Ovarian Cancer and Correlates With Low Grade Disease

The insulin-like growth factors (IGF) are important players in the development of gynecological malignancies, including epithelial ovarian cancer (EOC). The identification of biomarkers that can help in the diagnosis and scoring of EOC patients is of fundamental importance in clinical oncology. We h...

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Autores principales: Achlaug, Laris, Somri-Gannam, Lina, Meisel-Sharon, Shilhav, Sarfstein, Rive, Dixit, Manisha, Yakar, Shoshana, Hallak, Mordechai, Laron, Zvi, Werner, Haim, Bruchim, Ilan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8249937/
https://www.ncbi.nlm.nih.gov/pubmed/34220714
http://dx.doi.org/10.3389/fendo.2021.688104
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author Achlaug, Laris
Somri-Gannam, Lina
Meisel-Sharon, Shilhav
Sarfstein, Rive
Dixit, Manisha
Yakar, Shoshana
Hallak, Mordechai
Laron, Zvi
Werner, Haim
Bruchim, Ilan
author_facet Achlaug, Laris
Somri-Gannam, Lina
Meisel-Sharon, Shilhav
Sarfstein, Rive
Dixit, Manisha
Yakar, Shoshana
Hallak, Mordechai
Laron, Zvi
Werner, Haim
Bruchim, Ilan
author_sort Achlaug, Laris
collection PubMed
description The insulin-like growth factors (IGF) are important players in the development of gynecological malignancies, including epithelial ovarian cancer (EOC). The identification of biomarkers that can help in the diagnosis and scoring of EOC patients is of fundamental importance in clinical oncology. We have recently identified the ZYG11A gene as a new candidate target of IGF1 action. The aim of the present study was to evaluate the expression of ZYG11A in EOC patients and to correlate its pattern of expression with histological grade and pathological stage. Furthermore, and in view of previous analyses showing an interplay between ZYG11A, p53 and the IGF1 receptor (IGF1R), we assessed a potential coordinated expression of these proteins in EOC. In addition, zyg11a expression was assessed in ovaries and uteri of growth hormone receptor (GHR) knock-out mice. Tissue microarray analysis was conducted on 36 patients with EOC and expression of ZYG11A, IGF1R and p53 was assessed by immunohistochemistry. Expression levels were correlated with clinical parameters. qPCR was employed to assess zyg11a mRNA levels in mice tissues. Our analyses provide evidence of reduced ZYG11A expression in high grade tumors, consistent with a putative tumor suppressor role. In addition, an inverse correlation between ZYG11A and p53 levels in individual tumors was noticed. Taken together, our data justify further exploration of the role of ZYG11A as a novel biomarker in EOC.
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spelling pubmed-82499372021-07-03 ZYG11A Is Expressed in Epithelial Ovarian Cancer and Correlates With Low Grade Disease Achlaug, Laris Somri-Gannam, Lina Meisel-Sharon, Shilhav Sarfstein, Rive Dixit, Manisha Yakar, Shoshana Hallak, Mordechai Laron, Zvi Werner, Haim Bruchim, Ilan Front Endocrinol (Lausanne) Endocrinology The insulin-like growth factors (IGF) are important players in the development of gynecological malignancies, including epithelial ovarian cancer (EOC). The identification of biomarkers that can help in the diagnosis and scoring of EOC patients is of fundamental importance in clinical oncology. We have recently identified the ZYG11A gene as a new candidate target of IGF1 action. The aim of the present study was to evaluate the expression of ZYG11A in EOC patients and to correlate its pattern of expression with histological grade and pathological stage. Furthermore, and in view of previous analyses showing an interplay between ZYG11A, p53 and the IGF1 receptor (IGF1R), we assessed a potential coordinated expression of these proteins in EOC. In addition, zyg11a expression was assessed in ovaries and uteri of growth hormone receptor (GHR) knock-out mice. Tissue microarray analysis was conducted on 36 patients with EOC and expression of ZYG11A, IGF1R and p53 was assessed by immunohistochemistry. Expression levels were correlated with clinical parameters. qPCR was employed to assess zyg11a mRNA levels in mice tissues. Our analyses provide evidence of reduced ZYG11A expression in high grade tumors, consistent with a putative tumor suppressor role. In addition, an inverse correlation between ZYG11A and p53 levels in individual tumors was noticed. Taken together, our data justify further exploration of the role of ZYG11A as a novel biomarker in EOC. Frontiers Media S.A. 2021-06-18 /pmc/articles/PMC8249937/ /pubmed/34220714 http://dx.doi.org/10.3389/fendo.2021.688104 Text en Copyright © 2021 Achlaug, Somri-Gannam, Meisel-Sharon, Sarfstein, Dixit, Yakar, Hallak, Laron, Werner and Bruchim https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Achlaug, Laris
Somri-Gannam, Lina
Meisel-Sharon, Shilhav
Sarfstein, Rive
Dixit, Manisha
Yakar, Shoshana
Hallak, Mordechai
Laron, Zvi
Werner, Haim
Bruchim, Ilan
ZYG11A Is Expressed in Epithelial Ovarian Cancer and Correlates With Low Grade Disease
title ZYG11A Is Expressed in Epithelial Ovarian Cancer and Correlates With Low Grade Disease
title_full ZYG11A Is Expressed in Epithelial Ovarian Cancer and Correlates With Low Grade Disease
title_fullStr ZYG11A Is Expressed in Epithelial Ovarian Cancer and Correlates With Low Grade Disease
title_full_unstemmed ZYG11A Is Expressed in Epithelial Ovarian Cancer and Correlates With Low Grade Disease
title_short ZYG11A Is Expressed in Epithelial Ovarian Cancer and Correlates With Low Grade Disease
title_sort zyg11a is expressed in epithelial ovarian cancer and correlates with low grade disease
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8249937/
https://www.ncbi.nlm.nih.gov/pubmed/34220714
http://dx.doi.org/10.3389/fendo.2021.688104
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