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Coronavirus disease 2019 in pregnancy: Maternal and perinatal outcome

BACKGROUND: Since the advent of coronavirus disease 2019 (COVID-19) infection, there is debate whether pregnancy outcome in COVID-19 is more severe as compared to general population. Pregnant population is particularly susceptible to viral infections due to altered immune response. H1N1 infection an...

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Autores principales: Agarwal, Neha, Garg, Ruchika, Singh, Saroj, Agrawal, Arti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8249977/
https://www.ncbi.nlm.nih.gov/pubmed/34250128
http://dx.doi.org/10.4103/jehp.jehp_954_20
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author Agarwal, Neha
Garg, Ruchika
Singh, Saroj
Agrawal, Arti
author_facet Agarwal, Neha
Garg, Ruchika
Singh, Saroj
Agrawal, Arti
author_sort Agarwal, Neha
collection PubMed
description BACKGROUND: Since the advent of coronavirus disease 2019 (COVID-19) infection, there is debate whether pregnancy outcome in COVID-19 is more severe as compared to general population. Pregnant population is particularly susceptible to viral infections due to altered immune response. H1N1 infection and Zika virus infection led to unfavorable maternal and fetal outcomes. SARS during pregnancy has been linked previously with high risk of spontaneous abortions, preterm births and intrauterine growth restriction. The effects of this novel virus need to be studied. MATERIALS AND METHODS: This is a single-center descriptive prospective observational study of 65 pregnant women with reverse transcriptase–polymerase chain reaction confirmed COVID-19 infection, regardless of gestational age at diagnosis, admitted from April 15 to June 30, 2020, at the COVID hospital in SN Medical college a tertiary center of Agra in North India. Maternal and perinatal outcomes were studied. Data were analyzed using the SPSS software for windows. Continuous variables were expressed as mean ± standard deviation. Categorical variables were expressed as numbers and percentages. RESULTS: Majority 88.4% of the women were asymptomatic. Rest had mild illness only. Majority 94.23% were third-trimester pregnancies; preterm birth was not reported in any singleton pregnancy. Majority 85% were delivered by cesarean section done for obstetric indications. Maternal outcome of all patients was favourable, and only two women who had moderate pneumonia recovered. Maternal mortality was reported in only 1 case. All neonates were negative for COVID-19. Neonatal outcome was favorable. CONCLUSION: COVID-19 in pregnancy led to mild symptoms only. Infection in the third trimester did not led to adverse obstetric outcome including preterm labor and premature membrane rupture. SARSCoV2 infection in pregnancy did not increase the risk of maternal mortality. Vertical transmission of COVID-19 was not found in neonates. The maternal, neonatal, and perinatal outcomes of COVID-19 patients infected in late pregnancy were favorable.
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spelling pubmed-82499772021-07-09 Coronavirus disease 2019 in pregnancy: Maternal and perinatal outcome Agarwal, Neha Garg, Ruchika Singh, Saroj Agrawal, Arti J Educ Health Promot Original Article BACKGROUND: Since the advent of coronavirus disease 2019 (COVID-19) infection, there is debate whether pregnancy outcome in COVID-19 is more severe as compared to general population. Pregnant population is particularly susceptible to viral infections due to altered immune response. H1N1 infection and Zika virus infection led to unfavorable maternal and fetal outcomes. SARS during pregnancy has been linked previously with high risk of spontaneous abortions, preterm births and intrauterine growth restriction. The effects of this novel virus need to be studied. MATERIALS AND METHODS: This is a single-center descriptive prospective observational study of 65 pregnant women with reverse transcriptase–polymerase chain reaction confirmed COVID-19 infection, regardless of gestational age at diagnosis, admitted from April 15 to June 30, 2020, at the COVID hospital in SN Medical college a tertiary center of Agra in North India. Maternal and perinatal outcomes were studied. Data were analyzed using the SPSS software for windows. Continuous variables were expressed as mean ± standard deviation. Categorical variables were expressed as numbers and percentages. RESULTS: Majority 88.4% of the women were asymptomatic. Rest had mild illness only. Majority 94.23% were third-trimester pregnancies; preterm birth was not reported in any singleton pregnancy. Majority 85% were delivered by cesarean section done for obstetric indications. Maternal outcome of all patients was favourable, and only two women who had moderate pneumonia recovered. Maternal mortality was reported in only 1 case. All neonates were negative for COVID-19. Neonatal outcome was favorable. CONCLUSION: COVID-19 in pregnancy led to mild symptoms only. Infection in the third trimester did not led to adverse obstetric outcome including preterm labor and premature membrane rupture. SARSCoV2 infection in pregnancy did not increase the risk of maternal mortality. Vertical transmission of COVID-19 was not found in neonates. The maternal, neonatal, and perinatal outcomes of COVID-19 patients infected in late pregnancy were favorable. Wolters Kluwer - Medknow 2021-05-31 /pmc/articles/PMC8249977/ /pubmed/34250128 http://dx.doi.org/10.4103/jehp.jehp_954_20 Text en Copyright: © 2021 Journal of Education and Health Promotion https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Agarwal, Neha
Garg, Ruchika
Singh, Saroj
Agrawal, Arti
Coronavirus disease 2019 in pregnancy: Maternal and perinatal outcome
title Coronavirus disease 2019 in pregnancy: Maternal and perinatal outcome
title_full Coronavirus disease 2019 in pregnancy: Maternal and perinatal outcome
title_fullStr Coronavirus disease 2019 in pregnancy: Maternal and perinatal outcome
title_full_unstemmed Coronavirus disease 2019 in pregnancy: Maternal and perinatal outcome
title_short Coronavirus disease 2019 in pregnancy: Maternal and perinatal outcome
title_sort coronavirus disease 2019 in pregnancy: maternal and perinatal outcome
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8249977/
https://www.ncbi.nlm.nih.gov/pubmed/34250128
http://dx.doi.org/10.4103/jehp.jehp_954_20
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