Bilirubin Restrains the Anticancer Effect of Vemurafenib on BRAF-Mutant Melanoma Cells Through ERK-MNK1 Signaling

Melanoma, the most threatening cancer in the skin, has been considered to be driven by the carcinogenic RAF-MEK1/2-ERK1/2 signaling pathway. This signaling pathway is usually mainly dysregulated by mutations in BRAF or RAS in skin melanomas. Although inhibitors targeting mutant BRAF, such as vemuraf...

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Detalles Bibliográficos
Autores principales: Tan, Yufan, Zhong, Xiaoyu, Wen, Xizhi, Yao, Leyi, Shao, Zhenlong, Sun, Wenshuang, Wu, Jiawen, Wen, Guanmei, Tang, Daolin, Zhang, Xiaoshi, Liao, Yuning, Liu, Jinbao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8250144/
https://www.ncbi.nlm.nih.gov/pubmed/34222023
http://dx.doi.org/10.3389/fonc.2021.698888

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