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Increased B‐cell activity with consumption of activated monocytes in severe COVID‐19 patients
The pathogenesis of autoimmune complications triggered by SARS‐CoV2 has not been completely elucidated. Here, we performed an analysis of the cellular immune status, cell ratios, and monocyte populations of patients with COVID‐19 treated in the intensive care unit (ICU) (cohort 1, N = 23) and normal...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8250224/ https://www.ncbi.nlm.nih.gov/pubmed/33788264 http://dx.doi.org/10.1002/eji.202049163 |
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author | Kos, Igor Balensiefer, Benedikt Lesan, Vadim Kaddu‐Mulindwa, Dominic Thurner, Lorenz Christofyllakis, Konstantin Bittenbring, Joerg Thomas Ahlgrimm, Manfred Seiffert, Martina Wagenpfeil, Stefan Bewarder, Yvonne Neumann, Frank Rixecker, Torben Smola, Sigrun Link, Andreas Krawczyk, Marcin Lammert, Frank Lepper, Philipp M. Bals, Robert Stilgenbauer, Stephan Bewarder, Moritz |
author_facet | Kos, Igor Balensiefer, Benedikt Lesan, Vadim Kaddu‐Mulindwa, Dominic Thurner, Lorenz Christofyllakis, Konstantin Bittenbring, Joerg Thomas Ahlgrimm, Manfred Seiffert, Martina Wagenpfeil, Stefan Bewarder, Yvonne Neumann, Frank Rixecker, Torben Smola, Sigrun Link, Andreas Krawczyk, Marcin Lammert, Frank Lepper, Philipp M. Bals, Robert Stilgenbauer, Stephan Bewarder, Moritz |
author_sort | Kos, Igor |
collection | PubMed |
description | The pathogenesis of autoimmune complications triggered by SARS‐CoV2 has not been completely elucidated. Here, we performed an analysis of the cellular immune status, cell ratios, and monocyte populations of patients with COVID‐19 treated in the intensive care unit (ICU) (cohort 1, N = 23) and normal care unit (NCU) (cohort 2, n = 10) compared with control groups: patients treated in ICU for noninfectious reasons (cohort 3, n = 30) and patients treated in NCU for infections other than COVID‐19 (cohort 4, n = 21). Patients in cohort 1 presented significant differences in comparison with the other cohorts, including reduced frequencies of lymphocytes, reduced CD8+T‐cell count, reduced percentage of activated and intermediate monocytes and an increased B/T8 cell ratio. Over time, patients in cohort 1 who died presented with lower counts of B, T, CD4(+)T, CD8(+)T‐lymphocytes, NK cells, and activated monocytes. The B/T8 ratio was significantly lower in the group of survivors. In cohort 1, significantly higher levels of IgG1 and IgG3 were found, whereas cohort 3 presented higher levels of IgG3 compared to controls. Among many immune changes, an elevated B/T8‐cell ratio and a reduced rate of activated monocytes were mainly observed in patients with severe COVID‐19. Both parameters were associated with death in cohort 1. |
format | Online Article Text |
id | pubmed-8250224 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82502242021-07-02 Increased B‐cell activity with consumption of activated monocytes in severe COVID‐19 patients Kos, Igor Balensiefer, Benedikt Lesan, Vadim Kaddu‐Mulindwa, Dominic Thurner, Lorenz Christofyllakis, Konstantin Bittenbring, Joerg Thomas Ahlgrimm, Manfred Seiffert, Martina Wagenpfeil, Stefan Bewarder, Yvonne Neumann, Frank Rixecker, Torben Smola, Sigrun Link, Andreas Krawczyk, Marcin Lammert, Frank Lepper, Philipp M. Bals, Robert Stilgenbauer, Stephan Bewarder, Moritz Eur J Immunol Immunity to infection The pathogenesis of autoimmune complications triggered by SARS‐CoV2 has not been completely elucidated. Here, we performed an analysis of the cellular immune status, cell ratios, and monocyte populations of patients with COVID‐19 treated in the intensive care unit (ICU) (cohort 1, N = 23) and normal care unit (NCU) (cohort 2, n = 10) compared with control groups: patients treated in ICU for noninfectious reasons (cohort 3, n = 30) and patients treated in NCU for infections other than COVID‐19 (cohort 4, n = 21). Patients in cohort 1 presented significant differences in comparison with the other cohorts, including reduced frequencies of lymphocytes, reduced CD8+T‐cell count, reduced percentage of activated and intermediate monocytes and an increased B/T8 cell ratio. Over time, patients in cohort 1 who died presented with lower counts of B, T, CD4(+)T, CD8(+)T‐lymphocytes, NK cells, and activated monocytes. The B/T8 ratio was significantly lower in the group of survivors. In cohort 1, significantly higher levels of IgG1 and IgG3 were found, whereas cohort 3 presented higher levels of IgG3 compared to controls. Among many immune changes, an elevated B/T8‐cell ratio and a reduced rate of activated monocytes were mainly observed in patients with severe COVID‐19. Both parameters were associated with death in cohort 1. John Wiley and Sons Inc. 2021-04-19 2021-06 /pmc/articles/PMC8250224/ /pubmed/33788264 http://dx.doi.org/10.1002/eji.202049163 Text en © 2021 The Authors. European Journal of Immunology published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Immunity to infection Kos, Igor Balensiefer, Benedikt Lesan, Vadim Kaddu‐Mulindwa, Dominic Thurner, Lorenz Christofyllakis, Konstantin Bittenbring, Joerg Thomas Ahlgrimm, Manfred Seiffert, Martina Wagenpfeil, Stefan Bewarder, Yvonne Neumann, Frank Rixecker, Torben Smola, Sigrun Link, Andreas Krawczyk, Marcin Lammert, Frank Lepper, Philipp M. Bals, Robert Stilgenbauer, Stephan Bewarder, Moritz Increased B‐cell activity with consumption of activated monocytes in severe COVID‐19 patients |
title | Increased B‐cell activity with consumption of activated monocytes in severe COVID‐19 patients |
title_full | Increased B‐cell activity with consumption of activated monocytes in severe COVID‐19 patients |
title_fullStr | Increased B‐cell activity with consumption of activated monocytes in severe COVID‐19 patients |
title_full_unstemmed | Increased B‐cell activity with consumption of activated monocytes in severe COVID‐19 patients |
title_short | Increased B‐cell activity with consumption of activated monocytes in severe COVID‐19 patients |
title_sort | increased b‐cell activity with consumption of activated monocytes in severe covid‐19 patients |
topic | Immunity to infection |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8250224/ https://www.ncbi.nlm.nih.gov/pubmed/33788264 http://dx.doi.org/10.1002/eji.202049163 |
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