A single subcutaneous or intranasal immunization with adenovirus‐based SARS‐CoV‐2 vaccine induces robust humoral and cellular immune responses in mice

Optimal vaccines are needed for sustained suppression of SARS‐CoV‐2 and other novel coronaviruses. Here, we developed a recombinant type 5 adenovirus vector encoding the gene for the SARS‐CoV‐2 S1 subunit antigen (Ad5.SARS‐CoV‐2‐S1) for COVID‐19 immunization and evaluated its immunogenicity in mice....

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Eun, Weisel, Florian J., Balmert, Stephen C., Khan, Muhammad S., Huang, Shaohua, Erdos, Geza, Kenniston, Thomas W., Carey, Cara Donahue, Joachim, Stephen M., Conter, Laura J., Weisel, Nadine M., Okba, Nisreen M. A., Haagmans, Bart L., Percivalle, Elena, Cassaniti, Irene, Baldanti, Fausto, Korkmaz, Emrullah, Shlomchik, Mark J., Falo, Louis D., Gambotto, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Immunity to infection
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8250272/
https://www.ncbi.nlm.nih.gov/pubmed/33772778
http://dx.doi.org/10.1002/eji.202149167

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8250272/
https://www.ncbi.nlm.nih.gov/pubmed/33772778
http://dx.doi.org/10.1002/eji.202149167

Ejemplares similares