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Dental Biofilm Microbiota Dysbiosis Is Associated With the Risk of Acute Graft-Versus-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation

Acute graft-versus-host disease (aGVHD) is one of the major causes of death after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Recently, aGVHD onset was linked to intestinal microbiota (IM) dysbiosis. However, other bacterial-rich gastrointestinal sites, such as the mouth, which h...

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Autores principales: Heidrich, Vitor, Bruno, Julia S., Knebel, Franciele H., de Molla, Vinícius C., Miranda-Silva, Wanessa, Asprino, Paula F., Tucunduva, Luciana, Rocha, Vanderson, Novis, Yana, Arrais-Rodrigues, Celso, Fregnani, Eduardo R., Camargo, Anamaria A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8250416/
https://www.ncbi.nlm.nih.gov/pubmed/34220852
http://dx.doi.org/10.3389/fimmu.2021.692225
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author Heidrich, Vitor
Bruno, Julia S.
Knebel, Franciele H.
de Molla, Vinícius C.
Miranda-Silva, Wanessa
Asprino, Paula F.
Tucunduva, Luciana
Rocha, Vanderson
Novis, Yana
Arrais-Rodrigues, Celso
Fregnani, Eduardo R.
Camargo, Anamaria A.
author_facet Heidrich, Vitor
Bruno, Julia S.
Knebel, Franciele H.
de Molla, Vinícius C.
Miranda-Silva, Wanessa
Asprino, Paula F.
Tucunduva, Luciana
Rocha, Vanderson
Novis, Yana
Arrais-Rodrigues, Celso
Fregnani, Eduardo R.
Camargo, Anamaria A.
author_sort Heidrich, Vitor
collection PubMed
description Acute graft-versus-host disease (aGVHD) is one of the major causes of death after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Recently, aGVHD onset was linked to intestinal microbiota (IM) dysbiosis. However, other bacterial-rich gastrointestinal sites, such as the mouth, which hosts several distinctive microbiotas, may also impact the risk of GVHD. The dental biofilm microbiota (DBM) is highly diverse and, like the IM, interacts with host cells and modulates immune homeostasis. We characterized changes in the DBM of patients during allo-HSCT and evaluated whether the DBM could be associated with the risk of aGVHD. DBM dysbiosis during allo-HSCT was marked by a gradual loss of bacterial diversity and changes in DBM genera composition, with commensal genera reductions and potentially pathogenic bacteria overgrowths. High Streptococcus and high Corynebacterium relative abundance at preconditioning were associated with a higher risk of aGVHD (67% vs. 33%; HR = 2.89, P = 0.04 and 73% vs. 37%; HR = 2.74, P = 0.04, respectively), while high Veillonella relative abundance was associated with a lower risk of aGVHD (27% vs. 73%; HR = 0.24, P < 0.01). Enterococcus faecalis bloom during allo-HSCT was observed in 17% of allo-HSCT recipients and was associated with a higher risk of aGVHD (100% vs. 40%; HR = 4.07, P < 0.001) and severe aGVHD (60% vs. 12%; HR = 6.82, P = 0.01). To the best of our knowledge, this is the first study demonstrating that DBM dysbiosis is associated with the aGVHD risk after allo-HSCT.
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spelling pubmed-82504162021-07-03 Dental Biofilm Microbiota Dysbiosis Is Associated With the Risk of Acute Graft-Versus-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation Heidrich, Vitor Bruno, Julia S. Knebel, Franciele H. de Molla, Vinícius C. Miranda-Silva, Wanessa Asprino, Paula F. Tucunduva, Luciana Rocha, Vanderson Novis, Yana Arrais-Rodrigues, Celso Fregnani, Eduardo R. Camargo, Anamaria A. Front Immunol Immunology Acute graft-versus-host disease (aGVHD) is one of the major causes of death after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Recently, aGVHD onset was linked to intestinal microbiota (IM) dysbiosis. However, other bacterial-rich gastrointestinal sites, such as the mouth, which hosts several distinctive microbiotas, may also impact the risk of GVHD. The dental biofilm microbiota (DBM) is highly diverse and, like the IM, interacts with host cells and modulates immune homeostasis. We characterized changes in the DBM of patients during allo-HSCT and evaluated whether the DBM could be associated with the risk of aGVHD. DBM dysbiosis during allo-HSCT was marked by a gradual loss of bacterial diversity and changes in DBM genera composition, with commensal genera reductions and potentially pathogenic bacteria overgrowths. High Streptococcus and high Corynebacterium relative abundance at preconditioning were associated with a higher risk of aGVHD (67% vs. 33%; HR = 2.89, P = 0.04 and 73% vs. 37%; HR = 2.74, P = 0.04, respectively), while high Veillonella relative abundance was associated with a lower risk of aGVHD (27% vs. 73%; HR = 0.24, P < 0.01). Enterococcus faecalis bloom during allo-HSCT was observed in 17% of allo-HSCT recipients and was associated with a higher risk of aGVHD (100% vs. 40%; HR = 4.07, P < 0.001) and severe aGVHD (60% vs. 12%; HR = 6.82, P = 0.01). To the best of our knowledge, this is the first study demonstrating that DBM dysbiosis is associated with the aGVHD risk after allo-HSCT. Frontiers Media S.A. 2021-06-18 /pmc/articles/PMC8250416/ /pubmed/34220852 http://dx.doi.org/10.3389/fimmu.2021.692225 Text en Copyright © 2021 Heidrich, Bruno, Knebel, de Molla, Miranda-Silva, Asprino, Tucunduva, Rocha, Novis, Arrais-Rodrigues, Fregnani and Camargo https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Heidrich, Vitor
Bruno, Julia S.
Knebel, Franciele H.
de Molla, Vinícius C.
Miranda-Silva, Wanessa
Asprino, Paula F.
Tucunduva, Luciana
Rocha, Vanderson
Novis, Yana
Arrais-Rodrigues, Celso
Fregnani, Eduardo R.
Camargo, Anamaria A.
Dental Biofilm Microbiota Dysbiosis Is Associated With the Risk of Acute Graft-Versus-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation
title Dental Biofilm Microbiota Dysbiosis Is Associated With the Risk of Acute Graft-Versus-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation
title_full Dental Biofilm Microbiota Dysbiosis Is Associated With the Risk of Acute Graft-Versus-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation
title_fullStr Dental Biofilm Microbiota Dysbiosis Is Associated With the Risk of Acute Graft-Versus-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation
title_full_unstemmed Dental Biofilm Microbiota Dysbiosis Is Associated With the Risk of Acute Graft-Versus-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation
title_short Dental Biofilm Microbiota Dysbiosis Is Associated With the Risk of Acute Graft-Versus-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation
title_sort dental biofilm microbiota dysbiosis is associated with the risk of acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8250416/
https://www.ncbi.nlm.nih.gov/pubmed/34220852
http://dx.doi.org/10.3389/fimmu.2021.692225
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