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COVID‐19 in pregnancy—characteristics and outcomes of pregnant women admitted to hospital because of SARS‐CoV‐2 infection in the Nordic countries

INTRODUCTION: Population‐based studies about the consequences of SARS‐CoV‐2 infection (COVID‐19) in pregnancy are few and have limited generalizability to the Nordic population and healthcare systems. MATERIAL AND METHODS: This study examines pregnant women with COVID‐19 in the five Nordic countries...

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Autores principales: Engjom, Hilde, Aabakke, Anna J.M., Klungsøyr, Kari, Svanvik, Teresia, Äyräs, Outi, Jonasdottir, Eva, Thurn, Lars, Jones, Elin, Pettersson, Karin, Nyfløt, Lill T., Al‐Zirqi, Iqbal, Vangen, Siri, Júlíusson, Pétur B., Källén, Karin, Gissler, Mika, Krebs, Lone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8250817/
https://www.ncbi.nlm.nih.gov/pubmed/33885150
http://dx.doi.org/10.1111/aogs.14160
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author Engjom, Hilde
Aabakke, Anna J.M.
Klungsøyr, Kari
Svanvik, Teresia
Äyräs, Outi
Jonasdottir, Eva
Thurn, Lars
Jones, Elin
Pettersson, Karin
Nyfløt, Lill T.
Al‐Zirqi, Iqbal
Vangen, Siri
Júlíusson, Pétur B.
Källén, Karin
Gissler, Mika
Krebs, Lone
author_facet Engjom, Hilde
Aabakke, Anna J.M.
Klungsøyr, Kari
Svanvik, Teresia
Äyräs, Outi
Jonasdottir, Eva
Thurn, Lars
Jones, Elin
Pettersson, Karin
Nyfløt, Lill T.
Al‐Zirqi, Iqbal
Vangen, Siri
Júlíusson, Pétur B.
Källén, Karin
Gissler, Mika
Krebs, Lone
author_sort Engjom, Hilde
collection PubMed
description INTRODUCTION: Population‐based studies about the consequences of SARS‐CoV‐2 infection (COVID‐19) in pregnancy are few and have limited generalizability to the Nordic population and healthcare systems. MATERIAL AND METHODS: This study examines pregnant women with COVID‐19 in the five Nordic countries. Pregnant women were included if they were admitted to hospital between 1 March and 30 June 2020 and had a positive SARS‐CoV‐2 PCR test ≤14 days prior to admission. Cause of admission was classified as obstetric or COVID‐19‐related. RESULTS: In the study areas, 214 pregnant women with a positive test were admitted to hospital, of which 56 women required hospital care due to COVID‐19. The risk of admission due to COVID‐19 was 0.4/1000 deliveries in Denmark, Finland and Norway, and 3.8/1000 deliveries in the Swedish regions. Women hospitalized because of COVID‐19 were more frequently obese (p < 0.001) and had a migrant background (p < 0.001) compared with the total population of women who delivered in 2018. Twelve women (21.4%) needed intensive care. Among the 56 women admitted due to COVID‐19, 48 women delivered 51 infants. Preterm delivery (n = 12, 25%, p < 0.001) and cesarean delivery (n = 21, 43.8%, p < 0.001) were more frequent in women with COVID‐19 compared with women who delivered in 2018. No maternal deaths, stillbirths or neonatal deaths were reported. CONCLUSIONS: The risk of admission due to COVID‐19 disease in pregnancy was low in the Nordic countries. A fifth of the women required intensive care and we observed higher rates of preterm and cesarean deliveries. National public health policies appear to have had an impact on the risk of admission due to severe COVID‐19 disease in pregnancy. Nordic collaboration is important in collecting robust data and assessing rare outcomes.
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spelling pubmed-82508172021-07-02 COVID‐19 in pregnancy—characteristics and outcomes of pregnant women admitted to hospital because of SARS‐CoV‐2 infection in the Nordic countries Engjom, Hilde Aabakke, Anna J.M. Klungsøyr, Kari Svanvik, Teresia Äyräs, Outi Jonasdottir, Eva Thurn, Lars Jones, Elin Pettersson, Karin Nyfløt, Lill T. Al‐Zirqi, Iqbal Vangen, Siri Júlíusson, Pétur B. Källén, Karin Gissler, Mika Krebs, Lone Acta Obstet Gynecol Scand Pregnancy INTRODUCTION: Population‐based studies about the consequences of SARS‐CoV‐2 infection (COVID‐19) in pregnancy are few and have limited generalizability to the Nordic population and healthcare systems. MATERIAL AND METHODS: This study examines pregnant women with COVID‐19 in the five Nordic countries. Pregnant women were included if they were admitted to hospital between 1 March and 30 June 2020 and had a positive SARS‐CoV‐2 PCR test ≤14 days prior to admission. Cause of admission was classified as obstetric or COVID‐19‐related. RESULTS: In the study areas, 214 pregnant women with a positive test were admitted to hospital, of which 56 women required hospital care due to COVID‐19. The risk of admission due to COVID‐19 was 0.4/1000 deliveries in Denmark, Finland and Norway, and 3.8/1000 deliveries in the Swedish regions. Women hospitalized because of COVID‐19 were more frequently obese (p < 0.001) and had a migrant background (p < 0.001) compared with the total population of women who delivered in 2018. Twelve women (21.4%) needed intensive care. Among the 56 women admitted due to COVID‐19, 48 women delivered 51 infants. Preterm delivery (n = 12, 25%, p < 0.001) and cesarean delivery (n = 21, 43.8%, p < 0.001) were more frequent in women with COVID‐19 compared with women who delivered in 2018. No maternal deaths, stillbirths or neonatal deaths were reported. CONCLUSIONS: The risk of admission due to COVID‐19 disease in pregnancy was low in the Nordic countries. A fifth of the women required intensive care and we observed higher rates of preterm and cesarean deliveries. National public health policies appear to have had an impact on the risk of admission due to severe COVID‐19 disease in pregnancy. Nordic collaboration is important in collecting robust data and assessing rare outcomes. John Wiley and Sons Inc. 2021-05-07 2021-09 /pmc/articles/PMC8250817/ /pubmed/33885150 http://dx.doi.org/10.1111/aogs.14160 Text en © 2021 The Authors. Acta Obstetricia et Gynecologica Scandinavica published by John Wiley & Sons Ltd on behalf of Nordic Federation of Societies of Obstetrics and Gynecology (NFOG). https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Pregnancy
Engjom, Hilde
Aabakke, Anna J.M.
Klungsøyr, Kari
Svanvik, Teresia
Äyräs, Outi
Jonasdottir, Eva
Thurn, Lars
Jones, Elin
Pettersson, Karin
Nyfløt, Lill T.
Al‐Zirqi, Iqbal
Vangen, Siri
Júlíusson, Pétur B.
Källén, Karin
Gissler, Mika
Krebs, Lone
COVID‐19 in pregnancy—characteristics and outcomes of pregnant women admitted to hospital because of SARS‐CoV‐2 infection in the Nordic countries
title COVID‐19 in pregnancy—characteristics and outcomes of pregnant women admitted to hospital because of SARS‐CoV‐2 infection in the Nordic countries
title_full COVID‐19 in pregnancy—characteristics and outcomes of pregnant women admitted to hospital because of SARS‐CoV‐2 infection in the Nordic countries
title_fullStr COVID‐19 in pregnancy—characteristics and outcomes of pregnant women admitted to hospital because of SARS‐CoV‐2 infection in the Nordic countries
title_full_unstemmed COVID‐19 in pregnancy—characteristics and outcomes of pregnant women admitted to hospital because of SARS‐CoV‐2 infection in the Nordic countries
title_short COVID‐19 in pregnancy—characteristics and outcomes of pregnant women admitted to hospital because of SARS‐CoV‐2 infection in the Nordic countries
title_sort covid‐19 in pregnancy—characteristics and outcomes of pregnant women admitted to hospital because of sars‐cov‐2 infection in the nordic countries
topic Pregnancy
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8250817/
https://www.ncbi.nlm.nih.gov/pubmed/33885150
http://dx.doi.org/10.1111/aogs.14160
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