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Prior use of therapeutic anticoagulation does not protect against COVID‐19 related clinical outcomes in hospitalized patients: A propensity score‐matched cohort study
The hypercoagulable state observed in COVID‐19 could be responsible for morbidity and mortality. In this retrospective study we investigated whether therapeutic anticoagulation prior to infection has a beneficial effect in hospitalized COVID‐19 patients. This study included 1154 COVID‐19 patients ad...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8250934/ https://www.ncbi.nlm.nih.gov/pubmed/33899226 http://dx.doi.org/10.1111/bcp.14877 |
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author | Spiegelenberg, Janneke P. van Gelder, Marleen M. H. J. Maas, Martje L. Hovens, Marcel M. C. Esselink, Anne Dofferhoff, Anton S. M. Janssen, Rob van de Maat, Josephine Janssen, Nico Blaauw, Marc Hassing, Robert‐Jan van Apeldoorn, Marjan Kerckhoffs, Angèle Veerman, Karin Hoogerwerf, Jacobien Kramers, Cornelis Leentjens, Jenneke |
author_facet | Spiegelenberg, Janneke P. van Gelder, Marleen M. H. J. Maas, Martje L. Hovens, Marcel M. C. Esselink, Anne Dofferhoff, Anton S. M. Janssen, Rob van de Maat, Josephine Janssen, Nico Blaauw, Marc Hassing, Robert‐Jan van Apeldoorn, Marjan Kerckhoffs, Angèle Veerman, Karin Hoogerwerf, Jacobien Kramers, Cornelis Leentjens, Jenneke |
author_sort | Spiegelenberg, Janneke P. |
collection | PubMed |
description | The hypercoagulable state observed in COVID‐19 could be responsible for morbidity and mortality. In this retrospective study we investigated whether therapeutic anticoagulation prior to infection has a beneficial effect in hospitalized COVID‐19 patients. This study included 1154 COVID‐19 patients admitted to 6 hospitals in the Netherlands between March and May 2020. We applied 1:3 propensity score matching to evaluate the association between prior therapeutic anticoagulation use and clinical outcome, with in hospital mortality as primary endpoint. In total, 190 (16%) patients used therapeutic anticoagulation prior to admission. In the propensity score matched analyses, we observed no associations between prior use of therapeutic anticoagulation and overall mortality (risk ratio 1.02 [95% confidence interval; 0.80–1.30]) or length of hospital stay (7.0 [4–12] vs. 7.0 [4–12] days, P = .69), although we observed a lower risk of pulmonary embolism (0.19 [0.05–0.80]). This study shows that prior use of therapeutic anticoagulation is not associated with improved clinical outcome in hospitalized COVID‐19 patients. |
format | Online Article Text |
id | pubmed-8250934 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82509342021-07-02 Prior use of therapeutic anticoagulation does not protect against COVID‐19 related clinical outcomes in hospitalized patients: A propensity score‐matched cohort study Spiegelenberg, Janneke P. van Gelder, Marleen M. H. J. Maas, Martje L. Hovens, Marcel M. C. Esselink, Anne Dofferhoff, Anton S. M. Janssen, Rob van de Maat, Josephine Janssen, Nico Blaauw, Marc Hassing, Robert‐Jan van Apeldoorn, Marjan Kerckhoffs, Angèle Veerman, Karin Hoogerwerf, Jacobien Kramers, Cornelis Leentjens, Jenneke Br J Clin Pharmacol Short Reports The hypercoagulable state observed in COVID‐19 could be responsible for morbidity and mortality. In this retrospective study we investigated whether therapeutic anticoagulation prior to infection has a beneficial effect in hospitalized COVID‐19 patients. This study included 1154 COVID‐19 patients admitted to 6 hospitals in the Netherlands between March and May 2020. We applied 1:3 propensity score matching to evaluate the association between prior therapeutic anticoagulation use and clinical outcome, with in hospital mortality as primary endpoint. In total, 190 (16%) patients used therapeutic anticoagulation prior to admission. In the propensity score matched analyses, we observed no associations between prior use of therapeutic anticoagulation and overall mortality (risk ratio 1.02 [95% confidence interval; 0.80–1.30]) or length of hospital stay (7.0 [4–12] vs. 7.0 [4–12] days, P = .69), although we observed a lower risk of pulmonary embolism (0.19 [0.05–0.80]). This study shows that prior use of therapeutic anticoagulation is not associated with improved clinical outcome in hospitalized COVID‐19 patients. John Wiley and Sons Inc. 2021-05-07 2021-12 /pmc/articles/PMC8250934/ /pubmed/33899226 http://dx.doi.org/10.1111/bcp.14877 Text en © 2021 The Authors. British Journal of Clinical Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Short Reports Spiegelenberg, Janneke P. van Gelder, Marleen M. H. J. Maas, Martje L. Hovens, Marcel M. C. Esselink, Anne Dofferhoff, Anton S. M. Janssen, Rob van de Maat, Josephine Janssen, Nico Blaauw, Marc Hassing, Robert‐Jan van Apeldoorn, Marjan Kerckhoffs, Angèle Veerman, Karin Hoogerwerf, Jacobien Kramers, Cornelis Leentjens, Jenneke Prior use of therapeutic anticoagulation does not protect against COVID‐19 related clinical outcomes in hospitalized patients: A propensity score‐matched cohort study |
title | Prior use of therapeutic anticoagulation does not protect against COVID‐19 related clinical outcomes in hospitalized patients: A propensity score‐matched cohort study |
title_full | Prior use of therapeutic anticoagulation does not protect against COVID‐19 related clinical outcomes in hospitalized patients: A propensity score‐matched cohort study |
title_fullStr | Prior use of therapeutic anticoagulation does not protect against COVID‐19 related clinical outcomes in hospitalized patients: A propensity score‐matched cohort study |
title_full_unstemmed | Prior use of therapeutic anticoagulation does not protect against COVID‐19 related clinical outcomes in hospitalized patients: A propensity score‐matched cohort study |
title_short | Prior use of therapeutic anticoagulation does not protect against COVID‐19 related clinical outcomes in hospitalized patients: A propensity score‐matched cohort study |
title_sort | prior use of therapeutic anticoagulation does not protect against covid‐19 related clinical outcomes in hospitalized patients: a propensity score‐matched cohort study |
topic | Short Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8250934/ https://www.ncbi.nlm.nih.gov/pubmed/33899226 http://dx.doi.org/10.1111/bcp.14877 |
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