A SARS‐CoV‐2 Spike Binding DNA Aptamer that Inhibits Pseudovirus Infection by an RBD‐Independent Mechanism

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The receptor binding domain (RBD) of the spike glycoprotein of the coronavirus SARS‐CoV‐2 (CoV2‐S) binds to the human angiotensin‐converting enzyme 2 (ACE2) representing the initial contact point for leveraging the infection cascade. We used an automated selection process and identified an aptamer t...

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Detalles Bibliográficos
Autores principales: Schmitz, Anton, Weber, Anna, Bayin, Mehtap, Breuers, Stefan, Fieberg, Volkmar, Famulok, Michael, Mayer, Günter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8251191/
https://www.ncbi.nlm.nih.gov/pubmed/33683787
http://dx.doi.org/10.1002/anie.202100316
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