Cargando…

Randomised study: effects of the 5‐HT(4) receptor agonist felcisetrag vs placebo on gut transit in patients with gastroparesis

BACKGROUND: Gastroparesis is defined by delayed gastric emptying with associated symptoms in the absence of mechanical obstruction. AIM: To evaluate pharmacokinetics and pharmacodynamics of felcisetrag, a highly selective 5‐HT(4) receptor agonist, on total gut transit in patients with documented del...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chedid, Victor, Brandler, Justin, Arndt, Kayla, Vijayvargiya, Priya, Wang, Xiao Jing, Burton, Duane, Harmsen, W. Scott, Siegelman, Jenifer, Chen, Chunlin, Chen, Yinzhong, Almansa, Cristina, Dukes, George, Camilleri, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Randomised Clinical Trials
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8251541/ https://www.ncbi.nlm.nih.gov/pubmed/33711180 http://dx.doi.org/10.1111/apt.16304

Ejemplares similares

Effects of low-dose aspirin and heparin on the pregnancy outcome in women with antiphospholipid syndrome
por: Baiazid, Latifa, et al.
Publicado: (2022)

Implementing a home-based virtual hypertension programme—a pilot feasibility study
por: Gupta, Aditi, et al.
Publicado: (2022)

Randomised clinical trial: the 5‐HT4 agonist revexepride in patients with gastro‐oesophageal reflux disease who have persistent symptoms despite PPI therapy
por: Shaheen, N. J., et al.
Publicado: (2015)

The Effect of Hepatic Impairment on the Pharmacokinetics of Intravenously Administered Felcisetrag (TAK‐954)
por: Czerniak, Richard, et al.
Publicado: (2022)

Effect of S-ketamine on the intraoperative Surgical Pleth Index in patients undergoing video-assisted thoracoscopic surgery: a single-center randomized controlled clinical trial
por: Chen, Xian, et al.
Publicado: (2023)

Randomised clinical trial: 48 weeks of treatment with tenofovir amibufenamide versus tenofovir disoproxil fumarate for patients with chronic hepatitis B
por: Liu, Zhihong, et al.
Publicado: (2021)

Aquaporin Expression in Colonic Mucosal Biopsies From Irritable Bowel Syndrome With Diarrhea
por: Camilleri, Michael, et al.
Publicado: (2019)

Randomised clinical trial: the efficacy of prucalopride in patients with chronic intestinal pseudo-obstruction - a double-blind, placebo-controlled, cross-over, multiple n = 1 study
por: Emmanuel, A V, et al.
Publicado: (2012)

Randomised clinical trial: alosetron improves quality of life and reduces restriction of daily activities in women with severe diarrhoea-predominant IBS
por: Cremonini, F, et al.
Publicado: (2012)

Randomised clinical trial: the efficacy and safety of pancreatin enteric-coated minimicrospheres (Creon 40000 MMS) in patients with pancreatic exocrine insufficiency due to chronic pancreatitis - a double-blind, placebo-controlled study
por: Thorat, V, et al.
Publicado: (2012)

Randomised clinical trial: pre-dosing with taribavirin before starting pegylated interferon vs. standard combination regimen in treatment-naïve patients with chronic hepatitis C genotype 1
por: Palmer, M, et al.
Publicado: (2012)

Randomised clinical trial: vonoprazan, a novel potassium‐competitive acid blocker, vs. lansoprazole for the healing of erosive oesophagitis
por: Ashida, K., et al.
Publicado: (2015)

Randomised clinical trial: a placebo‐controlled study of intravenous golimumab induction therapy for ulcerative colitis
por: Rutgeerts, P., et al.
Publicado: (2015)

Randomised clinical trial: safety, tolerability, pharmacokinetics and pharmacodynamics of repeated doses of TAK-438 (vonoprazan), a novel potassium-competitive acid blocker, in healthy male subjects
por: Jenkins, H, et al.
Publicado: (2015)

Randomised clinical trial: a dose‐ranging study of vonoprazan, a novel potassium‐competitive acid blocker, vs. lansoprazole for the treatment of erosive oesophagitis
por: Ashida, K., et al.
Publicado: (2015)

Randomised clinical trial: the effects of a multispecies probiotic vs. placebo on innate immune function, bacterial translocation and gut permeability in patients with cirrhosis
por: Horvath, A., et al.
Publicado: (2016)

Randomised clinical trial: low‐FODMAP rye bread vs. regular rye bread to relieve the symptoms of irritable bowel syndrome
por: Laatikainen, R., et al.
Publicado: (2016)

Randomised clinical trial: exploratory phase 2 study of ONO‐2952 in diarrhoea‐predominant irritable bowel syndrome
por: Whitehead, W. E., et al.
Publicado: (2016)

Randomised clinical trial: a 1-week, double-blind, placebo-controlled study of pancreatin 25 000 Ph. Eur. minimicrospheres (Creon 25000 MMS) for pancreatic exocrine insufficiency after pancreatic surgery, with a 1-year open-label extension
por: Seiler, C M, et al.
Publicado: (2013)

Randomised clinical trial: the clinical efficacy and safety of an alginate‐antacid (Gaviscon Double Action) versus placebo, for decreasing upper gastrointestinal symptoms in symptomatic gastroesophageal reflux disease (GERD) in China
por: Sun, J., et al.
Publicado: (2015)

Randomised clinical trial: a phase 1, dose‐ranging study of the anti‐matrix metalloproteinase‐9 monoclonal antibody GS‐5745 versus placebo for ulcerative colitis
por: Sandborn, W. J., et al.
Publicado: (2016)

Randomised clinical trial: 2% taurolidine versus 0.9% saline locking in patients on home parenteral nutrition
por: Wouters, Y., et al.
Publicado: (2018)

Randomised clinical trial: a leucine‐metformin‐sildenafil combination (NS‐0200) vs placebo in patients with non‐alcoholic fatty liver disease
por: Chalasani, N., et al.
Publicado: (2018)

Randomised clinical trial: emricasan versus placebo significantly decreases ALT and caspase 3/7 activation in subjects with non‐alcoholic fatty liver disease
por: Shiffman, Mitchell, et al.
Publicado: (2018)

Randomised phase 3 trial: tegoprazan, a novel potassium‐competitive acid blocker, vs. esomeprazole in patients with erosive oesophagitis
por: Lee, Kwang Jae, et al.
Publicado: (2019)

Randomised clinical trial: efficacy and safety of vonoprazan vs. lansoprazole in patients with gastric or duodenal ulcers – results from two phase 3, non‐inferiority randomised controlled trials
por: Miwa, H., et al.
Publicado: (2016)

Randomised clinical trial: mucosal protection combined with acid suppression in the treatment of non‐erosive reflux disease – efficacy of Esoxx, a hyaluronic acid–chondroitin sulphate based bioadhesive formulation
por: Savarino, V., et al.
Publicado: (2017)

Randomised clinical trial: mesalazine versus placebo in the prevention of diverticulitis recurrence
por: Kruis, W., et al.
Publicado: (2017)

Laparoscopic versus open mesh repair of bilateral primary inguinal hernia: A three-armed Randomized controlled trial
por: Elmessiry, M.M., et al.
Publicado: (2020)

Randomised clinical trial: the effectiveness of Gaviscon Advance vs non‐alginate antacid in suppression of acid pocket and post‐prandial reflux in obese individuals after late‐night supper
por: Deraman, Mohd Adli, et al.
Publicado: (2020)

Randomised clinical trial: minesapride vs placebo for irritable bowel syndrome with predominant constipation
por: Hamatani, Tatsuto, et al.
Publicado: (2020)

Randomised clinical trial: linaclotide vs placebo—a study of bi‐directional gut and brain axis
por: Rao, Satish S.C., et al.
Publicado: (2020)

Evaluation of ultrasonic axillary dissection in preservation of intercostobrachial nerve and lymphatic sealing in breast cancer patients: Randomized controlled trial
por: Salama, Ahmed M.F., et al.
Publicado: (2020)

Randomised clinical trial: tegoprazan, a novel potassium‐competitive acid blocker, or lansoprazole in the treatment of gastric ulcer
por: Cho, Yu Kyung, et al.
Publicado: (2020)

Assessing effects of modification of middle meatal silastic splint after endoscopic sinus surgery for nasal polyps: A randomized controlled study
por: Odat, Haitham, et al.
Publicado: (2020)

Randomised clinical trial: intravenous vs oral iron for the treatment of anaemia after acute gastrointestinal bleeding
por: Ferrer‐Barceló, Luis, et al.
Publicado: (2019)

The therapeutic efficacy of Bifidobacterium animalis subsp. lactis BB‐12(®) in infant colic: A randomised, double blind, placebo‐controlled trial
por: Nocerino, Rita, et al.
Publicado: (2019)

The effects of extracorporeal shock wave therapy vs hand massage on serum lipids in overweight and obese women
por: Lee, Kyung.Jin, et al.
Publicado: (2021)

A prospective study of resolution of post-traumatic orbital complications using PRECLUDE® MVP: A randomized controlled trial
por: De-Moraes, Sylvio Luiz Costa, et al.
Publicado: (2020)

Effect of caffeine on postoperative bowel movement and defecation after cesarean section()
por: Zamanabadi, Mahnaz Narimani, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_jp716jtbke0groui8rthpn7ps1