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Strain‐Release Driven Spirocyclization of Azabicyclo[1.1.0]butyl Ketones
Due to their intrinsic rigidity, three‐dimensionality and structural novelty, spirocyclic molecules have become increasingly sought‐after moieties in drug discovery. Herein, we report a strain‐release driven synthesis of azetidine‐containing spirocycles by harnessing the inherent ring strain of the...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8251566/ https://www.ncbi.nlm.nih.gov/pubmed/33754432 http://dx.doi.org/10.1002/anie.202102754 |