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Natural Glycoforms of Human Interleukin 6 Show Atypical Plasma Clearance

A library of glycoforms of human interleukin 6 (IL‐6) comprising complex and mannosidic N‐glycans was generated by semisynthesis. The three segments were connected by sequential native chemical ligation followed by two‐step refolding. The central glycopeptide segments were assembled by pseudoproline...

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Detalles Bibliográficos
Autores principales:	Reif, Andreas, Lam, Kevin, Weidler, Sascha, Lott, Marie, Boos, Irene, Lokau, Juliane, Bretscher, Christian, Mönnich, Manuel, Perkams, Lukas, Schmälzlein, Marina, Graf, Christopher, Fischer, Jan‐Patrick, Lechner, Carolin, Hallstein, Kerstin, Becker, Stefan, Weyand, Michael, Steegborn, Clemens, Schultheiss, Gerhard, Rose‐John, Stefan, Garbers, Christoph, Unverzagt, Carlo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8251587/ https://www.ncbi.nlm.nih.gov/pubmed/33756033 http://dx.doi.org/10.1002/anie.202101496

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