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Structural and Mechanistic Insights into C−S Bond Formation in Gliotoxin

Glutathione‐S‐transferases (GSTs) usually detoxify xenobiotics. The human pathogenic fungus Aspergillus fumigatus however uses the exceptional GST GliG to incorporate two sulfur atoms into its virulence factor gliotoxin. Because these sulfurs are essential for biological activity, glutathionylation...

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Detalles Bibliográficos
Autores principales:	Scherlach, Kirstin, Kuttenlochner, Wolfgang, Scharf, Daniel H., Brakhage, Axel A., Hertweck, Christian, Groll, Michael, Huber, Eva M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8251611/ https://www.ncbi.nlm.nih.gov/pubmed/33909314 http://dx.doi.org/10.1002/anie.202104372

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