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Mannose‐6‐phosphate complex and improvement in biomechanical properties of the skin

BACKGROUND: The dermis is composed of a tangle of macromolecules that provides the skin its biomechanical properties. During chronological aging, fibroblasts lose their ability to synthesize collagen and an accumulation of matrix metalloproteinases leads to an increase in collagen degradation. As a...

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Autores principales: Meunier, Marie, Chapuis, Emilie, Lapierre, Laura, Auriol, Pascale, Paulus, Chantal, Elbaum, Boris, Don Simoni, Eglantine, Sandré, Jérôme, Auriol, Daniel, Scandolera, Amandine, Reynaud, Romain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8251629/
https://www.ncbi.nlm.nih.gov/pubmed/33580613
http://dx.doi.org/10.1111/jocd.14000
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author Meunier, Marie
Chapuis, Emilie
Lapierre, Laura
Auriol, Pascale
Paulus, Chantal
Elbaum, Boris
Don Simoni, Eglantine
Sandré, Jérôme
Auriol, Daniel
Scandolera, Amandine
Reynaud, Romain
author_facet Meunier, Marie
Chapuis, Emilie
Lapierre, Laura
Auriol, Pascale
Paulus, Chantal
Elbaum, Boris
Don Simoni, Eglantine
Sandré, Jérôme
Auriol, Daniel
Scandolera, Amandine
Reynaud, Romain
author_sort Meunier, Marie
collection PubMed
description BACKGROUND: The dermis is composed of a tangle of macromolecules that provides the skin its biomechanical properties. During chronological aging, fibroblasts lose their ability to synthesize collagen and an accumulation of matrix metalloproteinases leads to an increase in collagen degradation. As a result, there is a decline in the biomechanical properties of the skin. Skin aging is accelerated by external factors such as UV radiation and pollution, which induce accumulation of oxidants, and so of oxidized proteins in the skin. AIMS: Atomic force microscopy (AFM) has emerged as an alternative method for studying the biomechanical properties of skin cells and tissues. METHODS/RESULTS: Thus, we identified mannose‐6‐phosphate complex as a new powerful molecule capable of reversing the visible signs of aging by reorganizing the collagen network of the dermis and by improving the skin biomechanical properties. This effect was correlated with clinical studies that showed a marked antiaging effect through a reduction in the number of crow's feet and in the depth and size of neck wrinkles. CONCLUSION: Mannose‐6‐phosphate complex appeared to be able to protect proteins in the dermis scaffold against oxidation and degradation, allowing an improvement in the skin biomechanical properties.
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spelling pubmed-82516292021-07-06 Mannose‐6‐phosphate complex and improvement in biomechanical properties of the skin Meunier, Marie Chapuis, Emilie Lapierre, Laura Auriol, Pascale Paulus, Chantal Elbaum, Boris Don Simoni, Eglantine Sandré, Jérôme Auriol, Daniel Scandolera, Amandine Reynaud, Romain J Cosmet Dermatol Reviews BACKGROUND: The dermis is composed of a tangle of macromolecules that provides the skin its biomechanical properties. During chronological aging, fibroblasts lose their ability to synthesize collagen and an accumulation of matrix metalloproteinases leads to an increase in collagen degradation. As a result, there is a decline in the biomechanical properties of the skin. Skin aging is accelerated by external factors such as UV radiation and pollution, which induce accumulation of oxidants, and so of oxidized proteins in the skin. AIMS: Atomic force microscopy (AFM) has emerged as an alternative method for studying the biomechanical properties of skin cells and tissues. METHODS/RESULTS: Thus, we identified mannose‐6‐phosphate complex as a new powerful molecule capable of reversing the visible signs of aging by reorganizing the collagen network of the dermis and by improving the skin biomechanical properties. This effect was correlated with clinical studies that showed a marked antiaging effect through a reduction in the number of crow's feet and in the depth and size of neck wrinkles. CONCLUSION: Mannose‐6‐phosphate complex appeared to be able to protect proteins in the dermis scaffold against oxidation and degradation, allowing an improvement in the skin biomechanical properties. John Wiley and Sons Inc. 2021-03-10 2021-06 /pmc/articles/PMC8251629/ /pubmed/33580613 http://dx.doi.org/10.1111/jocd.14000 Text en © 2021 The Authors. Journal of Cosmetic Dermatology published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Reviews
Meunier, Marie
Chapuis, Emilie
Lapierre, Laura
Auriol, Pascale
Paulus, Chantal
Elbaum, Boris
Don Simoni, Eglantine
Sandré, Jérôme
Auriol, Daniel
Scandolera, Amandine
Reynaud, Romain
Mannose‐6‐phosphate complex and improvement in biomechanical properties of the skin
title Mannose‐6‐phosphate complex and improvement in biomechanical properties of the skin
title_full Mannose‐6‐phosphate complex and improvement in biomechanical properties of the skin
title_fullStr Mannose‐6‐phosphate complex and improvement in biomechanical properties of the skin
title_full_unstemmed Mannose‐6‐phosphate complex and improvement in biomechanical properties of the skin
title_short Mannose‐6‐phosphate complex and improvement in biomechanical properties of the skin
title_sort mannose‐6‐phosphate complex and improvement in biomechanical properties of the skin
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8251629/
https://www.ncbi.nlm.nih.gov/pubmed/33580613
http://dx.doi.org/10.1111/jocd.14000
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