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Evaluation of the Vestibulocochlear System in Patients with Pseudoexfoliation Syndrome

OBJECTIVES: Patients with pseudoexfoliation syndrome (PES) can also have sensorineural hearing loss as well as balance problems. Our aim was to evaluate vestibulocochlear system involvement in PES patients. MATERIALS AND METHODS: The study included 16 subjects with PES (study group) with a mean age...

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Autores principales: Bilgeç, Mustafa Değer, Erdoğmuş Küçükcan, Nagehan, Birdane, Leman, İncesulu, Armağan, Yıldırım, Nilgün
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Galenos Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8251668/
https://www.ncbi.nlm.nih.gov/pubmed/34187149
http://dx.doi.org/10.4274/tjo.galenos.2020.14892
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author Bilgeç, Mustafa Değer
Erdoğmuş Küçükcan, Nagehan
Birdane, Leman
İncesulu, Armağan
Yıldırım, Nilgün
author_facet Bilgeç, Mustafa Değer
Erdoğmuş Küçükcan, Nagehan
Birdane, Leman
İncesulu, Armağan
Yıldırım, Nilgün
author_sort Bilgeç, Mustafa Değer
collection PubMed
description OBJECTIVES: Patients with pseudoexfoliation syndrome (PES) can also have sensorineural hearing loss as well as balance problems. Our aim was to evaluate vestibulocochlear system involvement in PES patients. MATERIALS AND METHODS: The study included 16 subjects with PES (study group) with a mean age of 66.12±5.64 years and 17 healthy subjects (control group) with a mean age of 61.70±8.46 years. Both groups underwent ophthalmological, neuro-otological, audiological, and vestibular evaluation. Pure-tone audiometry and tympanometry were performed as audiological tests and bithermal caloric test and vestibular-evoked myogenic potential (VEMP) testing were used as vestibular tests. The Romberg, tandem Romberg, and Unterberger tests were also performed. RESULTS: In the PES group, bithermal caloric tests revealed right canal paresis in 6 patients, left canal paresis in 3 patients, and bilateral stimulation loss in 2 patients, despite no clinical evidence of balance loss. Paresis was not detected in any of the control subjects. Unilateral VEMP responses could not be obtained in 3 patients in the PES group. The ocular PES patients whose VEMP waves were obtained differed significantly from the control group (p<0.05). In office tests for vestibular evaluation, pathologic findings were found in 7 of 16 patients in the study group and only 4 subjects in the control group. Audiological evaluation with pure-tone thresholds revealed sensorineural decline at 4000 and 8000 Hertz in the PES patients. A statistically significant difference was found between the study group and the control group (p<0.05). CONCLUSION: Patients with PES showed elevation in pure-tone thresholds and a decrease in superior and inferior vestibular nerve function, demonstrating that the vestibular system as well as the auditory system are affected in PES.
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spelling pubmed-82516682021-07-13 Evaluation of the Vestibulocochlear System in Patients with Pseudoexfoliation Syndrome Bilgeç, Mustafa Değer Erdoğmuş Küçükcan, Nagehan Birdane, Leman İncesulu, Armağan Yıldırım, Nilgün Turk J Ophthalmol Original Article OBJECTIVES: Patients with pseudoexfoliation syndrome (PES) can also have sensorineural hearing loss as well as balance problems. Our aim was to evaluate vestibulocochlear system involvement in PES patients. MATERIALS AND METHODS: The study included 16 subjects with PES (study group) with a mean age of 66.12±5.64 years and 17 healthy subjects (control group) with a mean age of 61.70±8.46 years. Both groups underwent ophthalmological, neuro-otological, audiological, and vestibular evaluation. Pure-tone audiometry and tympanometry were performed as audiological tests and bithermal caloric test and vestibular-evoked myogenic potential (VEMP) testing were used as vestibular tests. The Romberg, tandem Romberg, and Unterberger tests were also performed. RESULTS: In the PES group, bithermal caloric tests revealed right canal paresis in 6 patients, left canal paresis in 3 patients, and bilateral stimulation loss in 2 patients, despite no clinical evidence of balance loss. Paresis was not detected in any of the control subjects. Unilateral VEMP responses could not be obtained in 3 patients in the PES group. The ocular PES patients whose VEMP waves were obtained differed significantly from the control group (p<0.05). In office tests for vestibular evaluation, pathologic findings were found in 7 of 16 patients in the study group and only 4 subjects in the control group. Audiological evaluation with pure-tone thresholds revealed sensorineural decline at 4000 and 8000 Hertz in the PES patients. A statistically significant difference was found between the study group and the control group (p<0.05). CONCLUSION: Patients with PES showed elevation in pure-tone thresholds and a decrease in superior and inferior vestibular nerve function, demonstrating that the vestibular system as well as the auditory system are affected in PES. Galenos Publishing 2021-06 2021-06-29 /pmc/articles/PMC8251668/ /pubmed/34187149 http://dx.doi.org/10.4274/tjo.galenos.2020.14892 Text en © Copyright 2021 by Turkish Ophthalmological Association | Turkish Journal of Ophthalmology, published by Galenos Publishing House. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Bilgeç, Mustafa Değer
Erdoğmuş Küçükcan, Nagehan
Birdane, Leman
İncesulu, Armağan
Yıldırım, Nilgün
Evaluation of the Vestibulocochlear System in Patients with Pseudoexfoliation Syndrome
title Evaluation of the Vestibulocochlear System in Patients with Pseudoexfoliation Syndrome
title_full Evaluation of the Vestibulocochlear System in Patients with Pseudoexfoliation Syndrome
title_fullStr Evaluation of the Vestibulocochlear System in Patients with Pseudoexfoliation Syndrome
title_full_unstemmed Evaluation of the Vestibulocochlear System in Patients with Pseudoexfoliation Syndrome
title_short Evaluation of the Vestibulocochlear System in Patients with Pseudoexfoliation Syndrome
title_sort evaluation of the vestibulocochlear system in patients with pseudoexfoliation syndrome
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8251668/
https://www.ncbi.nlm.nih.gov/pubmed/34187149
http://dx.doi.org/10.4274/tjo.galenos.2020.14892
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