Genetic Engineering in Combination with Semi‐Synthesis Leads to a New Route for Gram‐Scale Production of the Immunosuppressive Natural Product Brasilicardin A

Brasilicardin A (1) consists of an unusual anti/syn/anti‐perhydrophenanthrene skeleton with a carbohydrate side chain and an amino acid moiety. It exhibits potent immunosuppressive activity, yet its mode of action differs from standard drugs that are currently in use. Further pre‐clinical evaluation...

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Detalles Bibliográficos
Autores principales: Botas, Alma, Eitel, Michael, Schwarz, Paul N., Buchmann, Anina, Costales, Paula, Núñez, Luz Elena, Cortés, Jesús, Morís, Francisco, Krawiec, Michał, Wolański, Marcin, Gust, Bertolt, Rodriguez, Mirna, Fischer, Wolf‐Nicolas, Jandeleit, Bernd, Zakrzewska‐Czerwińska, Jolanta, Wohlleben, Wolfgang, Stegmann, Evi, Koch, Pierre, Méndez, Carmen, Gross, Harald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8251711/
https://www.ncbi.nlm.nih.gov/pubmed/33768597
http://dx.doi.org/10.1002/anie.202015852

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