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Enantioselective Total Synthesis and Structural Revision of Dysiherbol A

A 12‐step total synthesis of the natural product dysiherbol A, a strongly anti‐inflammatory and anti‐tumor avarane meroterpene isolated from the marine sponge Dysidea sp., was elaborated. As key steps, the synthesis features an enantioselective Cu‐catalyzed 1,4‐addition/enolate‐trapping opening move...

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Detalles Bibliográficos
Autores principales: Baars, Julian, Grimm, Isabelle, Blunk, Dirk, Neudörfl, Jörg‐Martin, Schmalz, Hans‐Günther
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8251742/
https://www.ncbi.nlm.nih.gov/pubmed/33978302
http://dx.doi.org/10.1002/anie.202105733

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