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Biological and Medical Applications of Calcium Phosphate Nanoparticles
Calcium phosphate nanoparticles have a high biocompatibility and biodegradability due to their chemical similarity to human hard tissue, for example, bone and teeth. They can be used as efficient carriers for different kinds of biomolecules such as nucleic acids, proteins, peptides, antibodies, or d...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8251768/ https://www.ncbi.nlm.nih.gov/pubmed/33577710 http://dx.doi.org/10.1002/chem.202005257 |
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author | Sokolova, Viktoriya Epple, Matthias |
author_facet | Sokolova, Viktoriya Epple, Matthias |
author_sort | Sokolova, Viktoriya |
collection | PubMed |
description | Calcium phosphate nanoparticles have a high biocompatibility and biodegradability due to their chemical similarity to human hard tissue, for example, bone and teeth. They can be used as efficient carriers for different kinds of biomolecules such as nucleic acids, proteins, peptides, antibodies, or drugs, which alone are not able to enter cells where their biological effect is required. They can be loaded with cargo molecules by incorporating them, unlike solid nanoparticles, and also by surface functionalization. This offers protection, for example, against nucleases, and the possibility for cell targeting. If such nanoparticles are functionalized with fluorescing dyes, they can be applied for imaging in vitro and in vivo. Synthesis, functionalization and cell uptake mechanisms of calcium phosphate nanoparticles are discussed together with applications in transfection, gene silencing, imaging, immunization, and bone substitution. Biodistribution data of calcium phosphate nanoparticles in vivo are reviewed. |
format | Online Article Text |
id | pubmed-8251768 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82517682021-07-07 Biological and Medical Applications of Calcium Phosphate Nanoparticles Sokolova, Viktoriya Epple, Matthias Chemistry Reviews Calcium phosphate nanoparticles have a high biocompatibility and biodegradability due to their chemical similarity to human hard tissue, for example, bone and teeth. They can be used as efficient carriers for different kinds of biomolecules such as nucleic acids, proteins, peptides, antibodies, or drugs, which alone are not able to enter cells where their biological effect is required. They can be loaded with cargo molecules by incorporating them, unlike solid nanoparticles, and also by surface functionalization. This offers protection, for example, against nucleases, and the possibility for cell targeting. If such nanoparticles are functionalized with fluorescing dyes, they can be applied for imaging in vitro and in vivo. Synthesis, functionalization and cell uptake mechanisms of calcium phosphate nanoparticles are discussed together with applications in transfection, gene silencing, imaging, immunization, and bone substitution. Biodistribution data of calcium phosphate nanoparticles in vivo are reviewed. John Wiley and Sons Inc. 2021-03-16 2021-05-12 /pmc/articles/PMC8251768/ /pubmed/33577710 http://dx.doi.org/10.1002/chem.202005257 Text en © 2021 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Reviews Sokolova, Viktoriya Epple, Matthias Biological and Medical Applications of Calcium Phosphate Nanoparticles |
title | Biological and Medical Applications of Calcium Phosphate Nanoparticles |
title_full | Biological and Medical Applications of Calcium Phosphate Nanoparticles |
title_fullStr | Biological and Medical Applications of Calcium Phosphate Nanoparticles |
title_full_unstemmed | Biological and Medical Applications of Calcium Phosphate Nanoparticles |
title_short | Biological and Medical Applications of Calcium Phosphate Nanoparticles |
title_sort | biological and medical applications of calcium phosphate nanoparticles |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8251768/ https://www.ncbi.nlm.nih.gov/pubmed/33577710 http://dx.doi.org/10.1002/chem.202005257 |
work_keys_str_mv | AT sokolovaviktoriya biologicalandmedicalapplicationsofcalciumphosphatenanoparticles AT epplematthias biologicalandmedicalapplicationsofcalciumphosphatenanoparticles |