High expression of Ras‐specific guanine nucleotide‐releasing factor 2 (RasGRF2) in lung adenocarcinoma is associated with tumor invasion and poor prognosis

The expression of Ras‐specific guanine nucleotide‐releasing factor 2 (RasGRF2) in lung adenocarcinomas was examined using immunohistochemistry in relation to clinicopathological characteristics and prognosis. In comparison to low expression, high expression of RasGRF2 was more closely associated wit...

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Autores principales: Nakagawa, Tomoki, Kim, YunJung, Kano, Junko, Murata, Yoshihiko, Kosibaty, Zeinab, Noguchi, Masayuki, Sakamoto, Noriaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8251786/
https://www.ncbi.nlm.nih.gov/pubmed/33709437
http://dx.doi.org/10.1111/pin.13069
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author Nakagawa, Tomoki
Kim, YunJung
Kano, Junko
Murata, Yoshihiko
Kosibaty, Zeinab
Noguchi, Masayuki
Sakamoto, Noriaki
author_facet Nakagawa, Tomoki
Kim, YunJung
Kano, Junko
Murata, Yoshihiko
Kosibaty, Zeinab
Noguchi, Masayuki
Sakamoto, Noriaki
author_sort Nakagawa, Tomoki
collection PubMed
description The expression of Ras‐specific guanine nucleotide‐releasing factor 2 (RasGRF2) in lung adenocarcinomas was examined using immunohistochemistry in relation to clinicopathological characteristics and prognosis. In comparison to low expression, high expression of RasGRF2 was more closely associated with poor prognosis. Interestingly, expression of phosphorylated epithelial cell transforming 2 (pECT2), which – like RasGRF2 – is also a guanine‐nucleotide exchange factor, was also associated with prognosis, and patients with high expression of both RasGRF2 and pECT2 had a much poorer outcome than those who were negative for both.
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spelling pubmed-82517862021-07-07 High expression of Ras‐specific guanine nucleotide‐releasing factor 2 (RasGRF2) in lung adenocarcinoma is associated with tumor invasion and poor prognosis Nakagawa, Tomoki Kim, YunJung Kano, Junko Murata, Yoshihiko Kosibaty, Zeinab Noguchi, Masayuki Sakamoto, Noriaki Pathol Int Short Communication The expression of Ras‐specific guanine nucleotide‐releasing factor 2 (RasGRF2) in lung adenocarcinomas was examined using immunohistochemistry in relation to clinicopathological characteristics and prognosis. In comparison to low expression, high expression of RasGRF2 was more closely associated with poor prognosis. Interestingly, expression of phosphorylated epithelial cell transforming 2 (pECT2), which – like RasGRF2 – is also a guanine‐nucleotide exchange factor, was also associated with prognosis, and patients with high expression of both RasGRF2 and pECT2 had a much poorer outcome than those who were negative for both. John Wiley and Sons Inc. 2021-03-11 2021-04 /pmc/articles/PMC8251786/ /pubmed/33709437 http://dx.doi.org/10.1111/pin.13069 Text en © 2021 The Authors. Pathology International published by Japanese Society of Pathology and John Wiley & Sons Australia, Ltd https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Nakagawa, Tomoki
Kim, YunJung
Kano, Junko
Murata, Yoshihiko
Kosibaty, Zeinab
Noguchi, Masayuki
Sakamoto, Noriaki
High expression of Ras‐specific guanine nucleotide‐releasing factor 2 (RasGRF2) in lung adenocarcinoma is associated with tumor invasion and poor prognosis
title High expression of Ras‐specific guanine nucleotide‐releasing factor 2 (RasGRF2) in lung adenocarcinoma is associated with tumor invasion and poor prognosis
title_full High expression of Ras‐specific guanine nucleotide‐releasing factor 2 (RasGRF2) in lung adenocarcinoma is associated with tumor invasion and poor prognosis
title_fullStr High expression of Ras‐specific guanine nucleotide‐releasing factor 2 (RasGRF2) in lung adenocarcinoma is associated with tumor invasion and poor prognosis
title_full_unstemmed High expression of Ras‐specific guanine nucleotide‐releasing factor 2 (RasGRF2) in lung adenocarcinoma is associated with tumor invasion and poor prognosis
title_short High expression of Ras‐specific guanine nucleotide‐releasing factor 2 (RasGRF2) in lung adenocarcinoma is associated with tumor invasion and poor prognosis
title_sort high expression of ras‐specific guanine nucleotide‐releasing factor 2 (rasgrf2) in lung adenocarcinoma is associated with tumor invasion and poor prognosis
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8251786/
https://www.ncbi.nlm.nih.gov/pubmed/33709437
http://dx.doi.org/10.1111/pin.13069
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