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The Potential Contribution of ABO, Lewis and Secretor Histo-Blood Group Carbohydrates in Infection by Toxoplasma gondii

The glycosyltransferases encoded by genes from the human ABO, Lewis, and Secretor histo-blood group systems synthesize part of the carbohydrate antigens in hematopoietic and non-hematopoietic tissues. The combined action of these glycosyltransferases strongly influences cell, tissue, mucosa, and exo...

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Autores principales: De Mattos, Luiz Carlos, Ferreira, Ana Iara Costa, de Oliveira, Karina Younan, Nakashima, Fabiana, Brandão, Cinara Cássia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8251793/
https://www.ncbi.nlm.nih.gov/pubmed/34222043
http://dx.doi.org/10.3389/fcimb.2021.671958
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author De Mattos, Luiz Carlos
Ferreira, Ana Iara Costa
de Oliveira, Karina Younan
Nakashima, Fabiana
Brandão, Cinara Cássia
author_facet De Mattos, Luiz Carlos
Ferreira, Ana Iara Costa
de Oliveira, Karina Younan
Nakashima, Fabiana
Brandão, Cinara Cássia
author_sort De Mattos, Luiz Carlos
collection PubMed
description The glycosyltransferases encoded by genes from the human ABO, Lewis, and Secretor histo-blood group systems synthesize part of the carbohydrate antigens in hematopoietic and non-hematopoietic tissues. The combined action of these glycosyltransferases strongly influences cell, tissue, mucosa, and exocrine secretion carbohydrate phenotypes, including those serving as habitat for mutualistic and pathogenic microorganisms. A set of reports investigated associations between Toxoplasma gondii infection and the ABO histo-blood group system, but the results are contradictory. As T. gondii uses the gastrointestinal tract as a route for infection, and in this organ, the expression of ABO, Lewis, and Secretor histo-blood group carbohydrates occurs, it is reasonable to suppose some biological relationship between them. This text reviewed association studies published in recent decades focusing on the potential contribution of the ABO, Lewis, and Secretor histo-blood group carbohydrates and infection by T. gondii.
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spelling pubmed-82517932021-07-03 The Potential Contribution of ABO, Lewis and Secretor Histo-Blood Group Carbohydrates in Infection by Toxoplasma gondii De Mattos, Luiz Carlos Ferreira, Ana Iara Costa de Oliveira, Karina Younan Nakashima, Fabiana Brandão, Cinara Cássia Front Cell Infect Microbiol Cellular and Infection Microbiology The glycosyltransferases encoded by genes from the human ABO, Lewis, and Secretor histo-blood group systems synthesize part of the carbohydrate antigens in hematopoietic and non-hematopoietic tissues. The combined action of these glycosyltransferases strongly influences cell, tissue, mucosa, and exocrine secretion carbohydrate phenotypes, including those serving as habitat for mutualistic and pathogenic microorganisms. A set of reports investigated associations between Toxoplasma gondii infection and the ABO histo-blood group system, but the results are contradictory. As T. gondii uses the gastrointestinal tract as a route for infection, and in this organ, the expression of ABO, Lewis, and Secretor histo-blood group carbohydrates occurs, it is reasonable to suppose some biological relationship between them. This text reviewed association studies published in recent decades focusing on the potential contribution of the ABO, Lewis, and Secretor histo-blood group carbohydrates and infection by T. gondii. Frontiers Media S.A. 2021-06-18 /pmc/articles/PMC8251793/ /pubmed/34222043 http://dx.doi.org/10.3389/fcimb.2021.671958 Text en Copyright © 2021 De Mattos, Ferreira, de Oliveira, Nakashima and Brandão https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
De Mattos, Luiz Carlos
Ferreira, Ana Iara Costa
de Oliveira, Karina Younan
Nakashima, Fabiana
Brandão, Cinara Cássia
The Potential Contribution of ABO, Lewis and Secretor Histo-Blood Group Carbohydrates in Infection by Toxoplasma gondii
title The Potential Contribution of ABO, Lewis and Secretor Histo-Blood Group Carbohydrates in Infection by Toxoplasma gondii
title_full The Potential Contribution of ABO, Lewis and Secretor Histo-Blood Group Carbohydrates in Infection by Toxoplasma gondii
title_fullStr The Potential Contribution of ABO, Lewis and Secretor Histo-Blood Group Carbohydrates in Infection by Toxoplasma gondii
title_full_unstemmed The Potential Contribution of ABO, Lewis and Secretor Histo-Blood Group Carbohydrates in Infection by Toxoplasma gondii
title_short The Potential Contribution of ABO, Lewis and Secretor Histo-Blood Group Carbohydrates in Infection by Toxoplasma gondii
title_sort potential contribution of abo, lewis and secretor histo-blood group carbohydrates in infection by toxoplasma gondii
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8251793/
https://www.ncbi.nlm.nih.gov/pubmed/34222043
http://dx.doi.org/10.3389/fcimb.2021.671958
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