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Clinico‐metabolic characterization improves the prognostic value of histological growth patterns in patients undergoing surgery for colorectal liver metastases
BACKGROUND AND OBJECTIVES: The histological growth pattern (HGP) represents a strong prognostic factor in patients undergoing surgery for colorectal liver metastases (CRLM). We evaluated whether the combination of HGP with clinico‐metabolic parameters could improve its prognostic value. METHODS: In...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8251827/ https://www.ncbi.nlm.nih.gov/pubmed/33751583 http://dx.doi.org/10.1002/jso.26466 |
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author | Bohlok, Ali Duran Derijckere, Ivan Azema, Hugues Lucidi, Valerio Vankerckhove, Sophie Hendlisz, Alain Van Laethem, Jean Luc Vierasu, Irina Goldman, Serge Flamen, Patrick Larsimont, Denis Demetter, Pieter Dirix, Luc Vermeulen, Peter Donckier, Vincent |
author_facet | Bohlok, Ali Duran Derijckere, Ivan Azema, Hugues Lucidi, Valerio Vankerckhove, Sophie Hendlisz, Alain Van Laethem, Jean Luc Vierasu, Irina Goldman, Serge Flamen, Patrick Larsimont, Denis Demetter, Pieter Dirix, Luc Vermeulen, Peter Donckier, Vincent |
author_sort | Bohlok, Ali |
collection | PubMed |
description | BACKGROUND AND OBJECTIVES: The histological growth pattern (HGP) represents a strong prognostic factor in patients undergoing surgery for colorectal liver metastases (CRLM). We evaluated whether the combination of HGP with clinico‐metabolic parameters could improve its prognostic value. METHODS: In a series of 108 patients undergoing resection of CRLM, the HGP of CRLM was scored according to international guidelines. Baseline clinico‐metabolic clinical status was evaluated using a metabolic‐Clinical Risk Score (mCRS), combining traditional Memorial Sloan Kettering‐CRS parameters with the tumor‐to‐liver glucose uptake ratio as measured with (18)Fluorodeoxyglucose/positron emission tomography. RESULTS: In patients with desmoplastic HGP (DHGP) CRLM (20% of all patients), 5‐ and 10‐years overall survival (OS) and disease free survival (DFS) were 66% and 43% and 37% and 24.5%, as compared with 35% and 21% and 11% and 11% in the non‐DHGP group (p = 0.07 and 0.054). Among DHGP patients, those with a low‐risk mCRS had improved postoperative outcomes, 5‐ and 10‐years OS and DFS reaching 83.3% and 62.5% and 50% and 33%, as compared with 18% and 0% and 0% and 0% in high‐risk mCRS patients (p = 0.007 and 0.003). In contrast, mCRS did not influence postoperative survivals in non‐DHGP patients. CONCLUSIONS: Combining the clinico‐metabolic characteristics with the HGP may improve prognostication in patients undergoing surgery for CRLM. |
format | Online Article Text |
id | pubmed-8251827 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82518272021-07-07 Clinico‐metabolic characterization improves the prognostic value of histological growth patterns in patients undergoing surgery for colorectal liver metastases Bohlok, Ali Duran Derijckere, Ivan Azema, Hugues Lucidi, Valerio Vankerckhove, Sophie Hendlisz, Alain Van Laethem, Jean Luc Vierasu, Irina Goldman, Serge Flamen, Patrick Larsimont, Denis Demetter, Pieter Dirix, Luc Vermeulen, Peter Donckier, Vincent J Surg Oncol Colorectal BACKGROUND AND OBJECTIVES: The histological growth pattern (HGP) represents a strong prognostic factor in patients undergoing surgery for colorectal liver metastases (CRLM). We evaluated whether the combination of HGP with clinico‐metabolic parameters could improve its prognostic value. METHODS: In a series of 108 patients undergoing resection of CRLM, the HGP of CRLM was scored according to international guidelines. Baseline clinico‐metabolic clinical status was evaluated using a metabolic‐Clinical Risk Score (mCRS), combining traditional Memorial Sloan Kettering‐CRS parameters with the tumor‐to‐liver glucose uptake ratio as measured with (18)Fluorodeoxyglucose/positron emission tomography. RESULTS: In patients with desmoplastic HGP (DHGP) CRLM (20% of all patients), 5‐ and 10‐years overall survival (OS) and disease free survival (DFS) were 66% and 43% and 37% and 24.5%, as compared with 35% and 21% and 11% and 11% in the non‐DHGP group (p = 0.07 and 0.054). Among DHGP patients, those with a low‐risk mCRS had improved postoperative outcomes, 5‐ and 10‐years OS and DFS reaching 83.3% and 62.5% and 50% and 33%, as compared with 18% and 0% and 0% and 0% in high‐risk mCRS patients (p = 0.007 and 0.003). In contrast, mCRS did not influence postoperative survivals in non‐DHGP patients. CONCLUSIONS: Combining the clinico‐metabolic characteristics with the HGP may improve prognostication in patients undergoing surgery for CRLM. John Wiley and Sons Inc. 2021-03-22 2021-06-15 /pmc/articles/PMC8251827/ /pubmed/33751583 http://dx.doi.org/10.1002/jso.26466 Text en © 2021 The Authors. Journal of Surgical Oncology published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Colorectal Bohlok, Ali Duran Derijckere, Ivan Azema, Hugues Lucidi, Valerio Vankerckhove, Sophie Hendlisz, Alain Van Laethem, Jean Luc Vierasu, Irina Goldman, Serge Flamen, Patrick Larsimont, Denis Demetter, Pieter Dirix, Luc Vermeulen, Peter Donckier, Vincent Clinico‐metabolic characterization improves the prognostic value of histological growth patterns in patients undergoing surgery for colorectal liver metastases |
title | Clinico‐metabolic characterization improves the prognostic value of histological growth patterns in patients undergoing surgery for colorectal liver metastases |
title_full | Clinico‐metabolic characterization improves the prognostic value of histological growth patterns in patients undergoing surgery for colorectal liver metastases |
title_fullStr | Clinico‐metabolic characterization improves the prognostic value of histological growth patterns in patients undergoing surgery for colorectal liver metastases |
title_full_unstemmed | Clinico‐metabolic characterization improves the prognostic value of histological growth patterns in patients undergoing surgery for colorectal liver metastases |
title_short | Clinico‐metabolic characterization improves the prognostic value of histological growth patterns in patients undergoing surgery for colorectal liver metastases |
title_sort | clinico‐metabolic characterization improves the prognostic value of histological growth patterns in patients undergoing surgery for colorectal liver metastases |
topic | Colorectal |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8251827/ https://www.ncbi.nlm.nih.gov/pubmed/33751583 http://dx.doi.org/10.1002/jso.26466 |
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