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Clinico‐metabolic characterization improves the prognostic value of histological growth patterns in patients undergoing surgery for colorectal liver metastases

BACKGROUND AND OBJECTIVES: The histological growth pattern (HGP) represents a strong prognostic factor in patients undergoing surgery for colorectal liver metastases (CRLM). We evaluated whether the combination of HGP with clinico‐metabolic parameters could improve its prognostic value. METHODS: In...

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Autores principales: Bohlok, Ali, Duran Derijckere, Ivan, Azema, Hugues, Lucidi, Valerio, Vankerckhove, Sophie, Hendlisz, Alain, Van Laethem, Jean Luc, Vierasu, Irina, Goldman, Serge, Flamen, Patrick, Larsimont, Denis, Demetter, Pieter, Dirix, Luc, Vermeulen, Peter, Donckier, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8251827/
https://www.ncbi.nlm.nih.gov/pubmed/33751583
http://dx.doi.org/10.1002/jso.26466
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author Bohlok, Ali
Duran Derijckere, Ivan
Azema, Hugues
Lucidi, Valerio
Vankerckhove, Sophie
Hendlisz, Alain
Van Laethem, Jean Luc
Vierasu, Irina
Goldman, Serge
Flamen, Patrick
Larsimont, Denis
Demetter, Pieter
Dirix, Luc
Vermeulen, Peter
Donckier, Vincent
author_facet Bohlok, Ali
Duran Derijckere, Ivan
Azema, Hugues
Lucidi, Valerio
Vankerckhove, Sophie
Hendlisz, Alain
Van Laethem, Jean Luc
Vierasu, Irina
Goldman, Serge
Flamen, Patrick
Larsimont, Denis
Demetter, Pieter
Dirix, Luc
Vermeulen, Peter
Donckier, Vincent
author_sort Bohlok, Ali
collection PubMed
description BACKGROUND AND OBJECTIVES: The histological growth pattern (HGP) represents a strong prognostic factor in patients undergoing surgery for colorectal liver metastases (CRLM). We evaluated whether the combination of HGP with clinico‐metabolic parameters could improve its prognostic value. METHODS: In a series of 108 patients undergoing resection of CRLM, the HGP of CRLM was scored according to international guidelines. Baseline clinico‐metabolic clinical status was evaluated using a metabolic‐Clinical Risk Score (mCRS), combining traditional Memorial Sloan Kettering‐CRS parameters with the tumor‐to‐liver glucose uptake ratio as measured with (18)Fluorodeoxyglucose/positron emission tomography. RESULTS: In patients with desmoplastic HGP (DHGP) CRLM (20% of all patients), 5‐ and 10‐years overall survival (OS) and disease free survival (DFS) were 66% and 43% and 37% and 24.5%, as compared with 35% and 21% and 11% and 11% in the non‐DHGP group (p = 0.07 and 0.054). Among DHGP patients, those with a low‐risk mCRS had improved postoperative outcomes, 5‐ and 10‐years OS and DFS reaching 83.3% and 62.5% and 50% and 33%, as compared with 18% and 0% and 0% and 0% in high‐risk mCRS patients (p = 0.007 and 0.003). In contrast, mCRS did not influence postoperative survivals in non‐DHGP patients. CONCLUSIONS: Combining the clinico‐metabolic characteristics with the HGP may improve prognostication in patients undergoing surgery for CRLM.
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spelling pubmed-82518272021-07-07 Clinico‐metabolic characterization improves the prognostic value of histological growth patterns in patients undergoing surgery for colorectal liver metastases Bohlok, Ali Duran Derijckere, Ivan Azema, Hugues Lucidi, Valerio Vankerckhove, Sophie Hendlisz, Alain Van Laethem, Jean Luc Vierasu, Irina Goldman, Serge Flamen, Patrick Larsimont, Denis Demetter, Pieter Dirix, Luc Vermeulen, Peter Donckier, Vincent J Surg Oncol Colorectal BACKGROUND AND OBJECTIVES: The histological growth pattern (HGP) represents a strong prognostic factor in patients undergoing surgery for colorectal liver metastases (CRLM). We evaluated whether the combination of HGP with clinico‐metabolic parameters could improve its prognostic value. METHODS: In a series of 108 patients undergoing resection of CRLM, the HGP of CRLM was scored according to international guidelines. Baseline clinico‐metabolic clinical status was evaluated using a metabolic‐Clinical Risk Score (mCRS), combining traditional Memorial Sloan Kettering‐CRS parameters with the tumor‐to‐liver glucose uptake ratio as measured with (18)Fluorodeoxyglucose/positron emission tomography. RESULTS: In patients with desmoplastic HGP (DHGP) CRLM (20% of all patients), 5‐ and 10‐years overall survival (OS) and disease free survival (DFS) were 66% and 43% and 37% and 24.5%, as compared with 35% and 21% and 11% and 11% in the non‐DHGP group (p = 0.07 and 0.054). Among DHGP patients, those with a low‐risk mCRS had improved postoperative outcomes, 5‐ and 10‐years OS and DFS reaching 83.3% and 62.5% and 50% and 33%, as compared with 18% and 0% and 0% and 0% in high‐risk mCRS patients (p = 0.007 and 0.003). In contrast, mCRS did not influence postoperative survivals in non‐DHGP patients. CONCLUSIONS: Combining the clinico‐metabolic characteristics with the HGP may improve prognostication in patients undergoing surgery for CRLM. John Wiley and Sons Inc. 2021-03-22 2021-06-15 /pmc/articles/PMC8251827/ /pubmed/33751583 http://dx.doi.org/10.1002/jso.26466 Text en © 2021 The Authors. Journal of Surgical Oncology published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Colorectal
Bohlok, Ali
Duran Derijckere, Ivan
Azema, Hugues
Lucidi, Valerio
Vankerckhove, Sophie
Hendlisz, Alain
Van Laethem, Jean Luc
Vierasu, Irina
Goldman, Serge
Flamen, Patrick
Larsimont, Denis
Demetter, Pieter
Dirix, Luc
Vermeulen, Peter
Donckier, Vincent
Clinico‐metabolic characterization improves the prognostic value of histological growth patterns in patients undergoing surgery for colorectal liver metastases
title Clinico‐metabolic characterization improves the prognostic value of histological growth patterns in patients undergoing surgery for colorectal liver metastases
title_full Clinico‐metabolic characterization improves the prognostic value of histological growth patterns in patients undergoing surgery for colorectal liver metastases
title_fullStr Clinico‐metabolic characterization improves the prognostic value of histological growth patterns in patients undergoing surgery for colorectal liver metastases
title_full_unstemmed Clinico‐metabolic characterization improves the prognostic value of histological growth patterns in patients undergoing surgery for colorectal liver metastases
title_short Clinico‐metabolic characterization improves the prognostic value of histological growth patterns in patients undergoing surgery for colorectal liver metastases
title_sort clinico‐metabolic characterization improves the prognostic value of histological growth patterns in patients undergoing surgery for colorectal liver metastases
topic Colorectal
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8251827/
https://www.ncbi.nlm.nih.gov/pubmed/33751583
http://dx.doi.org/10.1002/jso.26466
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