Cargando…
Non‐syndromic thoracic aortic aneurysm: cellular and molecular insights
Thoracic aortic aneurysm (TAA) develops silently and asymptomatically and is a major cause of mortality. TAA prevalence is greatly underestimated, it is usually diagnosed incidentally, and its treatment consists mainly of prophylactic surgery based on the aortic diameter. The lack of effective drugs...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Ltd
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8251829/ https://www.ncbi.nlm.nih.gov/pubmed/33885146 http://dx.doi.org/10.1002/path.5683 |
_version_ | 1783717170942836736 |
---|---|
author | Martin‐Blazquez, Ariadna Heredero, Angeles Aldamiz‐Echevarria, Gonzalo Martin‐Lorenzo, Marta Alvarez‐Llamas, Gloria |
author_facet | Martin‐Blazquez, Ariadna Heredero, Angeles Aldamiz‐Echevarria, Gonzalo Martin‐Lorenzo, Marta Alvarez‐Llamas, Gloria |
author_sort | Martin‐Blazquez, Ariadna |
collection | PubMed |
description | Thoracic aortic aneurysm (TAA) develops silently and asymptomatically and is a major cause of mortality. TAA prevalence is greatly underestimated, it is usually diagnosed incidentally, and its treatment consists mainly of prophylactic surgery based on the aortic diameter. The lack of effective drugs and biological markers to identify and stratify TAAs by risk before visible symptoms results from scant knowledge of its pathophysiological mechanisms. Here we integrate the structural impairment affecting non‐syndromic non‐familial TAA with the main cellular and molecular changes described so far and consider how these changes are interconnected through specific pathways. The ultimate goal is to define much‐needed novel markers of TAA, and so the potential of previously identified molecules to aid in early diagnosis/prognosis is also discussed. © 2021 The Authors. The Journal of Pathology published by John Wiley & Sons, Ltd. on behalf of The Pathological Society of Great Britain and Ireland. |
format | Online Article Text |
id | pubmed-8251829 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley & Sons, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-82518292021-07-07 Non‐syndromic thoracic aortic aneurysm: cellular and molecular insights Martin‐Blazquez, Ariadna Heredero, Angeles Aldamiz‐Echevarria, Gonzalo Martin‐Lorenzo, Marta Alvarez‐Llamas, Gloria J Pathol Reviews Thoracic aortic aneurysm (TAA) develops silently and asymptomatically and is a major cause of mortality. TAA prevalence is greatly underestimated, it is usually diagnosed incidentally, and its treatment consists mainly of prophylactic surgery based on the aortic diameter. The lack of effective drugs and biological markers to identify and stratify TAAs by risk before visible symptoms results from scant knowledge of its pathophysiological mechanisms. Here we integrate the structural impairment affecting non‐syndromic non‐familial TAA with the main cellular and molecular changes described so far and consider how these changes are interconnected through specific pathways. The ultimate goal is to define much‐needed novel markers of TAA, and so the potential of previously identified molecules to aid in early diagnosis/prognosis is also discussed. © 2021 The Authors. The Journal of Pathology published by John Wiley & Sons, Ltd. on behalf of The Pathological Society of Great Britain and Ireland. John Wiley & Sons, Ltd 2021-05-24 2021-07 /pmc/articles/PMC8251829/ /pubmed/33885146 http://dx.doi.org/10.1002/path.5683 Text en © 2021 The Authors. The Journal of Pathology published by John Wiley & Sons, Ltd. on behalf of The Pathological Society of Great Britain and Ireland. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Reviews Martin‐Blazquez, Ariadna Heredero, Angeles Aldamiz‐Echevarria, Gonzalo Martin‐Lorenzo, Marta Alvarez‐Llamas, Gloria Non‐syndromic thoracic aortic aneurysm: cellular and molecular insights |
title | Non‐syndromic thoracic aortic aneurysm: cellular and molecular insights |
title_full | Non‐syndromic thoracic aortic aneurysm: cellular and molecular insights |
title_fullStr | Non‐syndromic thoracic aortic aneurysm: cellular and molecular insights |
title_full_unstemmed | Non‐syndromic thoracic aortic aneurysm: cellular and molecular insights |
title_short | Non‐syndromic thoracic aortic aneurysm: cellular and molecular insights |
title_sort | non‐syndromic thoracic aortic aneurysm: cellular and molecular insights |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8251829/ https://www.ncbi.nlm.nih.gov/pubmed/33885146 http://dx.doi.org/10.1002/path.5683 |
work_keys_str_mv | AT martinblazquezariadna nonsyndromicthoracicaorticaneurysmcellularandmolecularinsights AT herederoangeles nonsyndromicthoracicaorticaneurysmcellularandmolecularinsights AT aldamizechevarriagonzalo nonsyndromicthoracicaorticaneurysmcellularandmolecularinsights AT martinlorenzomarta nonsyndromicthoracicaorticaneurysmcellularandmolecularinsights AT alvarezllamasgloria nonsyndromicthoracicaorticaneurysmcellularandmolecularinsights |