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Non‐syndromic thoracic aortic aneurysm: cellular and molecular insights

Thoracic aortic aneurysm (TAA) develops silently and asymptomatically and is a major cause of mortality. TAA prevalence is greatly underestimated, it is usually diagnosed incidentally, and its treatment consists mainly of prophylactic surgery based on the aortic diameter. The lack of effective drugs...

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Autores principales: Martin‐Blazquez, Ariadna, Heredero, Angeles, Aldamiz‐Echevarria, Gonzalo, Martin‐Lorenzo, Marta, Alvarez‐Llamas, Gloria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8251829/
https://www.ncbi.nlm.nih.gov/pubmed/33885146
http://dx.doi.org/10.1002/path.5683
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author Martin‐Blazquez, Ariadna
Heredero, Angeles
Aldamiz‐Echevarria, Gonzalo
Martin‐Lorenzo, Marta
Alvarez‐Llamas, Gloria
author_facet Martin‐Blazquez, Ariadna
Heredero, Angeles
Aldamiz‐Echevarria, Gonzalo
Martin‐Lorenzo, Marta
Alvarez‐Llamas, Gloria
author_sort Martin‐Blazquez, Ariadna
collection PubMed
description Thoracic aortic aneurysm (TAA) develops silently and asymptomatically and is a major cause of mortality. TAA prevalence is greatly underestimated, it is usually diagnosed incidentally, and its treatment consists mainly of prophylactic surgery based on the aortic diameter. The lack of effective drugs and biological markers to identify and stratify TAAs by risk before visible symptoms results from scant knowledge of its pathophysiological mechanisms. Here we integrate the structural impairment affecting non‐syndromic non‐familial TAA with the main cellular and molecular changes described so far and consider how these changes are interconnected through specific pathways. The ultimate goal is to define much‐needed novel markers of TAA, and so the potential of previously identified molecules to aid in early diagnosis/prognosis is also discussed. © 2021 The Authors. The Journal of Pathology published by John Wiley & Sons, Ltd. on behalf of The Pathological Society of Great Britain and Ireland.
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spelling pubmed-82518292021-07-07 Non‐syndromic thoracic aortic aneurysm: cellular and molecular insights Martin‐Blazquez, Ariadna Heredero, Angeles Aldamiz‐Echevarria, Gonzalo Martin‐Lorenzo, Marta Alvarez‐Llamas, Gloria J Pathol Reviews Thoracic aortic aneurysm (TAA) develops silently and asymptomatically and is a major cause of mortality. TAA prevalence is greatly underestimated, it is usually diagnosed incidentally, and its treatment consists mainly of prophylactic surgery based on the aortic diameter. The lack of effective drugs and biological markers to identify and stratify TAAs by risk before visible symptoms results from scant knowledge of its pathophysiological mechanisms. Here we integrate the structural impairment affecting non‐syndromic non‐familial TAA with the main cellular and molecular changes described so far and consider how these changes are interconnected through specific pathways. The ultimate goal is to define much‐needed novel markers of TAA, and so the potential of previously identified molecules to aid in early diagnosis/prognosis is also discussed. © 2021 The Authors. The Journal of Pathology published by John Wiley & Sons, Ltd. on behalf of The Pathological Society of Great Britain and Ireland. John Wiley & Sons, Ltd 2021-05-24 2021-07 /pmc/articles/PMC8251829/ /pubmed/33885146 http://dx.doi.org/10.1002/path.5683 Text en © 2021 The Authors. The Journal of Pathology published by John Wiley & Sons, Ltd. on behalf of The Pathological Society of Great Britain and Ireland. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Reviews
Martin‐Blazquez, Ariadna
Heredero, Angeles
Aldamiz‐Echevarria, Gonzalo
Martin‐Lorenzo, Marta
Alvarez‐Llamas, Gloria
Non‐syndromic thoracic aortic aneurysm: cellular and molecular insights
title Non‐syndromic thoracic aortic aneurysm: cellular and molecular insights
title_full Non‐syndromic thoracic aortic aneurysm: cellular and molecular insights
title_fullStr Non‐syndromic thoracic aortic aneurysm: cellular and molecular insights
title_full_unstemmed Non‐syndromic thoracic aortic aneurysm: cellular and molecular insights
title_short Non‐syndromic thoracic aortic aneurysm: cellular and molecular insights
title_sort non‐syndromic thoracic aortic aneurysm: cellular and molecular insights
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8251829/
https://www.ncbi.nlm.nih.gov/pubmed/33885146
http://dx.doi.org/10.1002/path.5683
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