Cargando…

Subcutaneous adipose tissue composition and function are unaffected by liraglutide‐induced weight loss in adults with type 1 diabetes

Adipose tissue is the primary energy reservoir of the human body, which also possesses endocrine functions. The glucagon‐like peptide agonist liraglutide produces weight loss, although the specific effects on adipose tissue are unknown. We aimed to characterize the white adipose tissue composition a...

Descripción completa

Detalles Bibliográficos
Autores principales: Wegeberg, Anne‐Marie, Meldgaard, Theresa, Bæk, Amanda, Drewes, Asbjørn Mohr, Vyberg, Mogens, Jessen, Niels, Brock, Birgitte, Brock, Christina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8251841/
https://www.ncbi.nlm.nih.gov/pubmed/33624417
http://dx.doi.org/10.1111/bcpt.13575
_version_ 1783717173534916608
author Wegeberg, Anne‐Marie
Meldgaard, Theresa
Bæk, Amanda
Drewes, Asbjørn Mohr
Vyberg, Mogens
Jessen, Niels
Brock, Birgitte
Brock, Christina
author_facet Wegeberg, Anne‐Marie
Meldgaard, Theresa
Bæk, Amanda
Drewes, Asbjørn Mohr
Vyberg, Mogens
Jessen, Niels
Brock, Birgitte
Brock, Christina
author_sort Wegeberg, Anne‐Marie
collection PubMed
description Adipose tissue is the primary energy reservoir of the human body, which also possesses endocrine functions. The glucagon‐like peptide agonist liraglutide produces weight loss, although the specific effects on adipose tissue are unknown. We aimed to characterize the white adipose tissue composition and pericellular fibrosis of subcutaneous adipose tissue in response to liraglutide treatment. Furthermore, we explored the level of circulating free fatty acids, cluster of differentiation 163 (CD163) macrophage marker, leptin and adiponectin. Thirty‐nine adults with type 1 diabetes and polyneuropathy were randomly assigned to 26 weeks of liraglutide or placebo treatment. Biopsies of subcutaneous tissue were formalin‐fixed stained with picrosirius red to visualize collagen or immunohistochemically stained for CD163. Serum concentrations of free fatty acids, CD163, leptin and adiponectin were assessed with immunoassays or multiplex panels. In comparison with placebo, liraglutide induced weight loss (3.38 kg, 95% CI −5.29; −1.48, P < 0.001), but did not cause any differences in cell size, distribution of CD163‐positive cells, pericellular fibrosis and serum levels of free fatty acids, CD163, leptin or adiponectin (all P < 0.1). Additionally, no associations between weight loss, cell size and serum markers were found (all P > 0.08). In conclusion, despite liraglutide's effect on weight loss, sustained alterations in subcutaneous adipose tissue did not seem to appear.
format Online
Article
Text
id pubmed-8251841
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-82518412021-07-07 Subcutaneous adipose tissue composition and function are unaffected by liraglutide‐induced weight loss in adults with type 1 diabetes Wegeberg, Anne‐Marie Meldgaard, Theresa Bæk, Amanda Drewes, Asbjørn Mohr Vyberg, Mogens Jessen, Niels Brock, Birgitte Brock, Christina Basic Clin Pharmacol Toxicol ORIGINAL ARTICLES Adipose tissue is the primary energy reservoir of the human body, which also possesses endocrine functions. The glucagon‐like peptide agonist liraglutide produces weight loss, although the specific effects on adipose tissue are unknown. We aimed to characterize the white adipose tissue composition and pericellular fibrosis of subcutaneous adipose tissue in response to liraglutide treatment. Furthermore, we explored the level of circulating free fatty acids, cluster of differentiation 163 (CD163) macrophage marker, leptin and adiponectin. Thirty‐nine adults with type 1 diabetes and polyneuropathy were randomly assigned to 26 weeks of liraglutide or placebo treatment. Biopsies of subcutaneous tissue were formalin‐fixed stained with picrosirius red to visualize collagen or immunohistochemically stained for CD163. Serum concentrations of free fatty acids, CD163, leptin and adiponectin were assessed with immunoassays or multiplex panels. In comparison with placebo, liraglutide induced weight loss (3.38 kg, 95% CI −5.29; −1.48, P < 0.001), but did not cause any differences in cell size, distribution of CD163‐positive cells, pericellular fibrosis and serum levels of free fatty acids, CD163, leptin or adiponectin (all P < 0.1). Additionally, no associations between weight loss, cell size and serum markers were found (all P > 0.08). In conclusion, despite liraglutide's effect on weight loss, sustained alterations in subcutaneous adipose tissue did not seem to appear. John Wiley and Sons Inc. 2021-03-05 2021-06 /pmc/articles/PMC8251841/ /pubmed/33624417 http://dx.doi.org/10.1111/bcpt.13575 Text en © 2021 The Authors. Basic & Clinical Pharmacology & Toxicology published by John Wiley & Sons Ltd on behalf of Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society). https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle ORIGINAL ARTICLES
Wegeberg, Anne‐Marie
Meldgaard, Theresa
Bæk, Amanda
Drewes, Asbjørn Mohr
Vyberg, Mogens
Jessen, Niels
Brock, Birgitte
Brock, Christina
Subcutaneous adipose tissue composition and function are unaffected by liraglutide‐induced weight loss in adults with type 1 diabetes
title Subcutaneous adipose tissue composition and function are unaffected by liraglutide‐induced weight loss in adults with type 1 diabetes
title_full Subcutaneous adipose tissue composition and function are unaffected by liraglutide‐induced weight loss in adults with type 1 diabetes
title_fullStr Subcutaneous adipose tissue composition and function are unaffected by liraglutide‐induced weight loss in adults with type 1 diabetes
title_full_unstemmed Subcutaneous adipose tissue composition and function are unaffected by liraglutide‐induced weight loss in adults with type 1 diabetes
title_short Subcutaneous adipose tissue composition and function are unaffected by liraglutide‐induced weight loss in adults with type 1 diabetes
title_sort subcutaneous adipose tissue composition and function are unaffected by liraglutide‐induced weight loss in adults with type 1 diabetes
topic ORIGINAL ARTICLES
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8251841/
https://www.ncbi.nlm.nih.gov/pubmed/33624417
http://dx.doi.org/10.1111/bcpt.13575
work_keys_str_mv AT wegebergannemarie subcutaneousadiposetissuecompositionandfunctionareunaffectedbyliraglutideinducedweightlossinadultswithtype1diabetes
AT meldgaardtheresa subcutaneousadiposetissuecompositionandfunctionareunaffectedbyliraglutideinducedweightlossinadultswithtype1diabetes
AT bækamanda subcutaneousadiposetissuecompositionandfunctionareunaffectedbyliraglutideinducedweightlossinadultswithtype1diabetes
AT drewesasbjørnmohr subcutaneousadiposetissuecompositionandfunctionareunaffectedbyliraglutideinducedweightlossinadultswithtype1diabetes
AT vybergmogens subcutaneousadiposetissuecompositionandfunctionareunaffectedbyliraglutideinducedweightlossinadultswithtype1diabetes
AT jessenniels subcutaneousadiposetissuecompositionandfunctionareunaffectedbyliraglutideinducedweightlossinadultswithtype1diabetes
AT brockbirgitte subcutaneousadiposetissuecompositionandfunctionareunaffectedbyliraglutideinducedweightlossinadultswithtype1diabetes
AT brockchristina subcutaneousadiposetissuecompositionandfunctionareunaffectedbyliraglutideinducedweightlossinadultswithtype1diabetes