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Reproducibility in Electroorganic Synthesis—Myths and Misunderstandings

The use of electric current as a traceless activator and reagent is experiencing a renaissance. This sustainable synthetic method is evolving into a hot topic in contemporary organic chemistry. Since researchers with various scientific backgrounds are entering this interdisciplinary field, different...

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Detalles Bibliográficos
Autores principales: Beil, Sebastian B., Pollok, Dennis, Waldvogel, Siegfried R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8251947/
https://www.ncbi.nlm.nih.gov/pubmed/33428811
http://dx.doi.org/10.1002/anie.202014544
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author Beil, Sebastian B.
Pollok, Dennis
Waldvogel, Siegfried R.
author_facet Beil, Sebastian B.
Pollok, Dennis
Waldvogel, Siegfried R.
author_sort Beil, Sebastian B.
collection PubMed
description The use of electric current as a traceless activator and reagent is experiencing a renaissance. This sustainable synthetic method is evolving into a hot topic in contemporary organic chemistry. Since researchers with various scientific backgrounds are entering this interdisciplinary field, different parameters and methods are reported to describe the experiments. The variation in the reported parameters can lead to problems with the reproducibility of the reported electroorganic syntheses. As an example, parameters such as current density or electrode distance are in some cases more significant than often anticipated. This Minireview provides guidelines on reporting electrosynthetic data and dispels myths about this technique, thereby streamlining the experimental parameters to facilitate reproducibility.
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spelling pubmed-82519472021-07-07 Reproducibility in Electroorganic Synthesis—Myths and Misunderstandings Beil, Sebastian B. Pollok, Dennis Waldvogel, Siegfried R. Angew Chem Int Ed Engl Minireviews The use of electric current as a traceless activator and reagent is experiencing a renaissance. This sustainable synthetic method is evolving into a hot topic in contemporary organic chemistry. Since researchers with various scientific backgrounds are entering this interdisciplinary field, different parameters and methods are reported to describe the experiments. The variation in the reported parameters can lead to problems with the reproducibility of the reported electroorganic syntheses. As an example, parameters such as current density or electrode distance are in some cases more significant than often anticipated. This Minireview provides guidelines on reporting electrosynthetic data and dispels myths about this technique, thereby streamlining the experimental parameters to facilitate reproducibility. John Wiley and Sons Inc. 2021-03-03 2021-06-25 /pmc/articles/PMC8251947/ /pubmed/33428811 http://dx.doi.org/10.1002/anie.202014544 Text en © 2021 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Minireviews
Beil, Sebastian B.
Pollok, Dennis
Waldvogel, Siegfried R.
Reproducibility in Electroorganic Synthesis—Myths and Misunderstandings
title Reproducibility in Electroorganic Synthesis—Myths and Misunderstandings
title_full Reproducibility in Electroorganic Synthesis—Myths and Misunderstandings
title_fullStr Reproducibility in Electroorganic Synthesis—Myths and Misunderstandings
title_full_unstemmed Reproducibility in Electroorganic Synthesis—Myths and Misunderstandings
title_short Reproducibility in Electroorganic Synthesis—Myths and Misunderstandings
title_sort reproducibility in electroorganic synthesis—myths and misunderstandings
topic Minireviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8251947/
https://www.ncbi.nlm.nih.gov/pubmed/33428811
http://dx.doi.org/10.1002/anie.202014544
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