Discovery of Oligosaccharide Antigens for Semi‐Synthetic Glycoconjugate Vaccine Leads against Streptococcus suis Serotypes 2, 3, 9 and 14

Streptococcus suis bacteria are one of the most serious health problems for pigs and an emerging zoonotic agent in humans working in the swine industry. S. suis bacteria express capsular polysaccharides (CPS) a major bacterial virulence factor that define the serotypes. Oligosaccharides resembling t...

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Autores principales: Zhang, Shuo, Sella, Mauro, Sianturi, Julinton, Priegue, Patricia, Shen, Dacheng, Seeberger, Peter H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252040/
https://www.ncbi.nlm.nih.gov/pubmed/33852172
http://dx.doi.org/10.1002/anie.202103990
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author Zhang, Shuo
Sella, Mauro
Sianturi, Julinton
Priegue, Patricia
Shen, Dacheng
Seeberger, Peter H.
author_facet Zhang, Shuo
Sella, Mauro
Sianturi, Julinton
Priegue, Patricia
Shen, Dacheng
Seeberger, Peter H.
author_sort Zhang, Shuo
collection PubMed
description Streptococcus suis bacteria are one of the most serious health problems for pigs and an emerging zoonotic agent in humans working in the swine industry. S. suis bacteria express capsular polysaccharides (CPS) a major bacterial virulence factor that define the serotypes. Oligosaccharides resembling the CPS of S. suis serotypes 2, 3, 9, and 14 have been synthesized, glycans related to serotypes 2 and 9 were placed on glycan array surfaces to screen blood from infected pigs. Lead antigens for the development of semi‐synthetic S. suis serotypes 2 and 9 glycoconjugate veterinary vaccines were identified in this way.
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spelling pubmed-82520402021-07-07 Discovery of Oligosaccharide Antigens for Semi‐Synthetic Glycoconjugate Vaccine Leads against Streptococcus suis Serotypes 2, 3, 9 and 14 Zhang, Shuo Sella, Mauro Sianturi, Julinton Priegue, Patricia Shen, Dacheng Seeberger, Peter H. Angew Chem Int Ed Engl Research Articles Streptococcus suis bacteria are one of the most serious health problems for pigs and an emerging zoonotic agent in humans working in the swine industry. S. suis bacteria express capsular polysaccharides (CPS) a major bacterial virulence factor that define the serotypes. Oligosaccharides resembling the CPS of S. suis serotypes 2, 3, 9, and 14 have been synthesized, glycans related to serotypes 2 and 9 were placed on glycan array surfaces to screen blood from infected pigs. Lead antigens for the development of semi‐synthetic S. suis serotypes 2 and 9 glycoconjugate veterinary vaccines were identified in this way. John Wiley and Sons Inc. 2021-05-19 2021-06-21 /pmc/articles/PMC8252040/ /pubmed/33852172 http://dx.doi.org/10.1002/anie.202103990 Text en © 2021 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research Articles
Zhang, Shuo
Sella, Mauro
Sianturi, Julinton
Priegue, Patricia
Shen, Dacheng
Seeberger, Peter H.
Discovery of Oligosaccharide Antigens for Semi‐Synthetic Glycoconjugate Vaccine Leads against Streptococcus suis Serotypes 2, 3, 9 and 14
title Discovery of Oligosaccharide Antigens for Semi‐Synthetic Glycoconjugate Vaccine Leads against Streptococcus suis Serotypes 2, 3, 9 and 14
title_full Discovery of Oligosaccharide Antigens for Semi‐Synthetic Glycoconjugate Vaccine Leads against Streptococcus suis Serotypes 2, 3, 9 and 14
title_fullStr Discovery of Oligosaccharide Antigens for Semi‐Synthetic Glycoconjugate Vaccine Leads against Streptococcus suis Serotypes 2, 3, 9 and 14
title_full_unstemmed Discovery of Oligosaccharide Antigens for Semi‐Synthetic Glycoconjugate Vaccine Leads against Streptococcus suis Serotypes 2, 3, 9 and 14
title_short Discovery of Oligosaccharide Antigens for Semi‐Synthetic Glycoconjugate Vaccine Leads against Streptococcus suis Serotypes 2, 3, 9 and 14
title_sort discovery of oligosaccharide antigens for semi‐synthetic glycoconjugate vaccine leads against streptococcus suis serotypes 2, 3, 9 and 14
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252040/
https://www.ncbi.nlm.nih.gov/pubmed/33852172
http://dx.doi.org/10.1002/anie.202103990
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