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New Platinum(II) Complexes Affecting Different Biomolecular Targets in Resistant Ovarian Carcinoma Cells
Resistance to platinum‐based anticancer drugs represents an important limit for their clinical effectiveness and one of the most important field of investigation in the context of platinum compounds. From our previous studies, Pt(II) complexes containing the triphenylphosphino moiety have been emerg...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252049/ https://www.ncbi.nlm.nih.gov/pubmed/33751814 http://dx.doi.org/10.1002/cmdc.202100075 |
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author | Hyeraci, Mariafrancesca Scalcon, Valeria Folda, Alessandra Labella, Luca Marchetti, Fabio Samaritani, Simona Rigobello, Maria Pia Dalla Via, Lisa |
author_facet | Hyeraci, Mariafrancesca Scalcon, Valeria Folda, Alessandra Labella, Luca Marchetti, Fabio Samaritani, Simona Rigobello, Maria Pia Dalla Via, Lisa |
author_sort | Hyeraci, Mariafrancesca |
collection | PubMed |
description | Resistance to platinum‐based anticancer drugs represents an important limit for their clinical effectiveness and one of the most important field of investigation in the context of platinum compounds. From our previous studies, Pt(II) complexes containing the triphenylphosphino moiety have been emerging as promising agents, showing significant cytotoxicity to resistant ovarian carcinoma cells. Two brominated triphenylphosphino trans‐platinum derivatives were prepared and evaluated on human tumor cell lines, sensitive and resistant to cisplatin. The new complexes exert a notable antiproliferative effect on resistant ovarian carcinoma cells, showing a remarkable intracellular accumulation and the ability to interact with different intracellular targets. The interaction with DNA, the collapse of mitochondrial transmembrane potential, and the impairment of intracellular redox state were demonstrated. Moreover, a selectivity towards the selenocysteine of thioredoxin reductase was observed. The mechanism of action is discussed with regard to the resistance phenomenon in ovarian carcinoma cells. |
format | Online Article Text |
id | pubmed-8252049 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82520492021-07-07 New Platinum(II) Complexes Affecting Different Biomolecular Targets in Resistant Ovarian Carcinoma Cells Hyeraci, Mariafrancesca Scalcon, Valeria Folda, Alessandra Labella, Luca Marchetti, Fabio Samaritani, Simona Rigobello, Maria Pia Dalla Via, Lisa ChemMedChem Full Papers Resistance to platinum‐based anticancer drugs represents an important limit for their clinical effectiveness and one of the most important field of investigation in the context of platinum compounds. From our previous studies, Pt(II) complexes containing the triphenylphosphino moiety have been emerging as promising agents, showing significant cytotoxicity to resistant ovarian carcinoma cells. Two brominated triphenylphosphino trans‐platinum derivatives were prepared and evaluated on human tumor cell lines, sensitive and resistant to cisplatin. The new complexes exert a notable antiproliferative effect on resistant ovarian carcinoma cells, showing a remarkable intracellular accumulation and the ability to interact with different intracellular targets. The interaction with DNA, the collapse of mitochondrial transmembrane potential, and the impairment of intracellular redox state were demonstrated. Moreover, a selectivity towards the selenocysteine of thioredoxin reductase was observed. The mechanism of action is discussed with regard to the resistance phenomenon in ovarian carcinoma cells. John Wiley and Sons Inc. 2021-04-06 2021-06-17 /pmc/articles/PMC8252049/ /pubmed/33751814 http://dx.doi.org/10.1002/cmdc.202100075 Text en © 2021 The Authors. ChemMedChem published by Wiley-VCH GmbH https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Full Papers Hyeraci, Mariafrancesca Scalcon, Valeria Folda, Alessandra Labella, Luca Marchetti, Fabio Samaritani, Simona Rigobello, Maria Pia Dalla Via, Lisa New Platinum(II) Complexes Affecting Different Biomolecular Targets in Resistant Ovarian Carcinoma Cells |
title | New Platinum(II) Complexes Affecting Different Biomolecular Targets in Resistant Ovarian Carcinoma Cells |
title_full | New Platinum(II) Complexes Affecting Different Biomolecular Targets in Resistant Ovarian Carcinoma Cells |
title_fullStr | New Platinum(II) Complexes Affecting Different Biomolecular Targets in Resistant Ovarian Carcinoma Cells |
title_full_unstemmed | New Platinum(II) Complexes Affecting Different Biomolecular Targets in Resistant Ovarian Carcinoma Cells |
title_short | New Platinum(II) Complexes Affecting Different Biomolecular Targets in Resistant Ovarian Carcinoma Cells |
title_sort | new platinum(ii) complexes affecting different biomolecular targets in resistant ovarian carcinoma cells |
topic | Full Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252049/ https://www.ncbi.nlm.nih.gov/pubmed/33751814 http://dx.doi.org/10.1002/cmdc.202100075 |
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