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A novel hydrogen peroxide evolved CHO host can improve the expression of difficult to express bispecific antibodies

The manufacture of bispecific antibodies by Chinese hamster ovary (CHO) cells is often hindered by lower product yields compared to monoclonal antibodies. Recently, reactive oxygen species have been shown to negatively impact antibody production. By contrast, strategies to boost cellular antioxidant...

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Detalles Bibliográficos
Autores principales:	Mistry, Rajesh K., Kelsall, Emma, Sou, Si Nga, Barker, Harriet, Jenns, Mike, Willis, Katie, Zurlo, Fabio, Hatton, Diane, Gibson, Suzanne J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	ARTICLES
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252053/ https://www.ncbi.nlm.nih.gov/pubmed/33675232 http://dx.doi.org/10.1002/bit.27744

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