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A single QTL with large effect is associated with female functional virginity in an asexual parasitoid wasp

During the transition from sexual to asexual reproduction, a suite of reproduction‐related sexual traits become superfluous, and may be selected against if costly. Female functional virginity refers to asexual females resisting to mate or not fertilizing eggs after mating. These traits appear to be...

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Autores principales: Ma, Wen‐Juan, Pannebakker, Bart A., Li, Xuan, Geuverink, Elzemiek, Anvar, Seyed Yahya, Veltsos, Paris, Schwander, Tanja, van de Zande, Louis, Beukeboom, Leo W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252104/
https://www.ncbi.nlm.nih.gov/pubmed/33638236
http://dx.doi.org/10.1111/mec.15863
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author Ma, Wen‐Juan
Pannebakker, Bart A.
Li, Xuan
Geuverink, Elzemiek
Anvar, Seyed Yahya
Veltsos, Paris
Schwander, Tanja
van de Zande, Louis
Beukeboom, Leo W.
author_facet Ma, Wen‐Juan
Pannebakker, Bart A.
Li, Xuan
Geuverink, Elzemiek
Anvar, Seyed Yahya
Veltsos, Paris
Schwander, Tanja
van de Zande, Louis
Beukeboom, Leo W.
author_sort Ma, Wen‐Juan
collection PubMed
description During the transition from sexual to asexual reproduction, a suite of reproduction‐related sexual traits become superfluous, and may be selected against if costly. Female functional virginity refers to asexual females resisting to mate or not fertilizing eggs after mating. These traits appear to be among the first that evolve during transitions from sexual to asexual reproduction. The genetic basis of female functional virginity remains elusive. Previously, we reported that female functional virginity segregates as expected for a single recessive locus in the asexual parasitoid wasp Asobara japonica. Here, we investigate the genetic basis of this trait by quantitative trait loci (QTL) mapping and candidate gene analyses. Consistent with the segregation of phenotypes, we found a single QTL of large effect, spanning over 4.23 Mb and comprising at least 131 protein‐coding genes, of which 15 featured sex‐biased expression in the related sexual species Asobara tabida. Two of the 15 sex‐biased genes were previously identified to differ between related sexual and asexual population/species: CD151 antigen and nuclear pore complex protein Nup50. A third gene, hormone receptor 4, is involved in steroid hormone mediated mating behaviour. Overall, our results are consistent with a single locus, or a cluster of closely linked loci, underlying rapid evolution of female functional virginity in the transition to asexuality. Once this variant, causing rejection to mate, has swept through a population, the flanking region does not get smaller owing to lack of recombination in asexuals.
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spelling pubmed-82521042021-07-07 A single QTL with large effect is associated with female functional virginity in an asexual parasitoid wasp Ma, Wen‐Juan Pannebakker, Bart A. Li, Xuan Geuverink, Elzemiek Anvar, Seyed Yahya Veltsos, Paris Schwander, Tanja van de Zande, Louis Beukeboom, Leo W. Mol Ecol ORIGINAL ARTICLES During the transition from sexual to asexual reproduction, a suite of reproduction‐related sexual traits become superfluous, and may be selected against if costly. Female functional virginity refers to asexual females resisting to mate or not fertilizing eggs after mating. These traits appear to be among the first that evolve during transitions from sexual to asexual reproduction. The genetic basis of female functional virginity remains elusive. Previously, we reported that female functional virginity segregates as expected for a single recessive locus in the asexual parasitoid wasp Asobara japonica. Here, we investigate the genetic basis of this trait by quantitative trait loci (QTL) mapping and candidate gene analyses. Consistent with the segregation of phenotypes, we found a single QTL of large effect, spanning over 4.23 Mb and comprising at least 131 protein‐coding genes, of which 15 featured sex‐biased expression in the related sexual species Asobara tabida. Two of the 15 sex‐biased genes were previously identified to differ between related sexual and asexual population/species: CD151 antigen and nuclear pore complex protein Nup50. A third gene, hormone receptor 4, is involved in steroid hormone mediated mating behaviour. Overall, our results are consistent with a single locus, or a cluster of closely linked loci, underlying rapid evolution of female functional virginity in the transition to asexuality. Once this variant, causing rejection to mate, has swept through a population, the flanking region does not get smaller owing to lack of recombination in asexuals. John Wiley and Sons Inc. 2021-03-15 2021-05 /pmc/articles/PMC8252104/ /pubmed/33638236 http://dx.doi.org/10.1111/mec.15863 Text en © 2021 The Authors. Molecular Ecology published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle ORIGINAL ARTICLES
Ma, Wen‐Juan
Pannebakker, Bart A.
Li, Xuan
Geuverink, Elzemiek
Anvar, Seyed Yahya
Veltsos, Paris
Schwander, Tanja
van de Zande, Louis
Beukeboom, Leo W.
A single QTL with large effect is associated with female functional virginity in an asexual parasitoid wasp
title A single QTL with large effect is associated with female functional virginity in an asexual parasitoid wasp
title_full A single QTL with large effect is associated with female functional virginity in an asexual parasitoid wasp
title_fullStr A single QTL with large effect is associated with female functional virginity in an asexual parasitoid wasp
title_full_unstemmed A single QTL with large effect is associated with female functional virginity in an asexual parasitoid wasp
title_short A single QTL with large effect is associated with female functional virginity in an asexual parasitoid wasp
title_sort single qtl with large effect is associated with female functional virginity in an asexual parasitoid wasp
topic ORIGINAL ARTICLES
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252104/
https://www.ncbi.nlm.nih.gov/pubmed/33638236
http://dx.doi.org/10.1111/mec.15863
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