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RNA-seq analysis reveals significant transcriptome changes in huntingtin-null human neuroblastoma cells

BACKGROUND: Huntingtin (Htt) protein is the product of the gene mutated in Huntington’s disease (HD), a fatal, autosomal dominant, neurodegenerative disorder. Normal Htt is essential for early embryogenesis and the development of the central nervous system. However, the role of Htt in adult tissues...

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Detalles Bibliográficos
Autores principales:	Bensalel, Johanna, Xu, Hongyuan, Lu, Michael L., Capobianco, Enrico, Wei, Jianning
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252266/ https://www.ncbi.nlm.nih.gov/pubmed/34215255 http://dx.doi.org/10.1186/s12920-021-01022-w

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