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Stratification in health and survival after age 100: evidence from Danish centenarians

BACKGROUND: The existence of a super-select group of centenarians that demonstrates increased survivorship has been hypothesized. However, it is unknown if this super-select group possesses similar characteristics apart from extreme longevity. METHODS: In this study, we analyse high-quality health a...

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Autores principales: Alvarez, Jesús-Adrián, Medford, Anthony, Strozza, Cosmo, Thinggaard, Mikael, Christensen, Kaare
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252309/
https://www.ncbi.nlm.nih.gov/pubmed/34210289
http://dx.doi.org/10.1186/s12877-021-02326-3
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author Alvarez, Jesús-Adrián
Medford, Anthony
Strozza, Cosmo
Thinggaard, Mikael
Christensen, Kaare
author_facet Alvarez, Jesús-Adrián
Medford, Anthony
Strozza, Cosmo
Thinggaard, Mikael
Christensen, Kaare
author_sort Alvarez, Jesús-Adrián
collection PubMed
description BACKGROUND: The existence of a super-select group of centenarians that demonstrates increased survivorship has been hypothesized. However, it is unknown if this super-select group possesses similar characteristics apart from extreme longevity. METHODS: In this study, we analyse high-quality health and survival data of Danish centenarians born in 1895, 1905 and 1910. We use Latent Class Analysis to identify unobserved health classes and to test whether these super-select lives share similar health characteristics. RESULTS: We find that, even after age 100, a clear and distinct gradient in health exists and that this gradient is remarkably similar across different birth cohorts of centenarians. Based on the level of health, we identify three clusters of centenarians - robust, frail and intermediate - and show that these groups have different survival prospects. The most distinctive characteristic of the robust centenarians is the outperformance in different health dimensions (physical, functional and cognitive). Finally, we show that our health class categorizations are good predictors of the survival prospects of centenarians. CONCLUSIONS: There is a clear stratification in health and functioning among those over 100 years of age and these differences are associated with survival beyond age 100. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12877-021-02326-3.
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spelling pubmed-82523092021-07-06 Stratification in health and survival after age 100: evidence from Danish centenarians Alvarez, Jesús-Adrián Medford, Anthony Strozza, Cosmo Thinggaard, Mikael Christensen, Kaare BMC Geriatr Research BACKGROUND: The existence of a super-select group of centenarians that demonstrates increased survivorship has been hypothesized. However, it is unknown if this super-select group possesses similar characteristics apart from extreme longevity. METHODS: In this study, we analyse high-quality health and survival data of Danish centenarians born in 1895, 1905 and 1910. We use Latent Class Analysis to identify unobserved health classes and to test whether these super-select lives share similar health characteristics. RESULTS: We find that, even after age 100, a clear and distinct gradient in health exists and that this gradient is remarkably similar across different birth cohorts of centenarians. Based on the level of health, we identify three clusters of centenarians - robust, frail and intermediate - and show that these groups have different survival prospects. The most distinctive characteristic of the robust centenarians is the outperformance in different health dimensions (physical, functional and cognitive). Finally, we show that our health class categorizations are good predictors of the survival prospects of centenarians. CONCLUSIONS: There is a clear stratification in health and functioning among those over 100 years of age and these differences are associated with survival beyond age 100. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12877-021-02326-3. BioMed Central 2021-07-01 /pmc/articles/PMC8252309/ /pubmed/34210289 http://dx.doi.org/10.1186/s12877-021-02326-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Alvarez, Jesús-Adrián
Medford, Anthony
Strozza, Cosmo
Thinggaard, Mikael
Christensen, Kaare
Stratification in health and survival after age 100: evidence from Danish centenarians
title Stratification in health and survival after age 100: evidence from Danish centenarians
title_full Stratification in health and survival after age 100: evidence from Danish centenarians
title_fullStr Stratification in health and survival after age 100: evidence from Danish centenarians
title_full_unstemmed Stratification in health and survival after age 100: evidence from Danish centenarians
title_short Stratification in health and survival after age 100: evidence from Danish centenarians
title_sort stratification in health and survival after age 100: evidence from danish centenarians
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252309/
https://www.ncbi.nlm.nih.gov/pubmed/34210289
http://dx.doi.org/10.1186/s12877-021-02326-3
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