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Health-Related Quality of Life in Asian Differentiated Thyroid Cancer Survivors

BACKGROUND: Health-related quality of life (HRQoL) is important for differentiated thyroid cancer survivors, but data for Asian survivors is lacking. This study aimed to have an overview of, and identify any disease-or treatment-related factors associated with, HRQoL in Asian differentiated thyroid...

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Autores principales: Chan, Wing-Lok, Choi, Horace Cheuk-Wai, Lang, Brian, Wong, Kai-Pun, Yuen, Kwok-Keung, Lam, Ka-On, Lee, Victor Ho-Fun, Kwong, Dora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252343/
https://www.ncbi.nlm.nih.gov/pubmed/34189945
http://dx.doi.org/10.1177/10732748211029726
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author Chan, Wing-Lok
Choi, Horace Cheuk-Wai
Lang, Brian
Wong, Kai-Pun
Yuen, Kwok-Keung
Lam, Ka-On
Lee, Victor Ho-Fun
Kwong, Dora
author_facet Chan, Wing-Lok
Choi, Horace Cheuk-Wai
Lang, Brian
Wong, Kai-Pun
Yuen, Kwok-Keung
Lam, Ka-On
Lee, Victor Ho-Fun
Kwong, Dora
author_sort Chan, Wing-Lok
collection PubMed
description BACKGROUND: Health-related quality of life (HRQoL) is important for differentiated thyroid cancer survivors, but data for Asian survivors is lacking. This study aimed to have an overview of, and identify any disease-or treatment-related factors associated with, HRQoL in Asian differentiated thyroid cancer survivors. PATIENTS AND METHODS: Thyroid cancer survivors were recruited from the thyroid clinics at Queen Mary Hospital, Hong Kong from February 2016 to December 2016. All adult differentiated thyroid cancer patients with stable disease more than or equal to 1 year received a survey on HRQoL using the European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) and Thyroid cancer specific quality of life (THYCA-QoL) questionnaire. Clinical information was collected retrospectively from the computerized clinical management system. To identify factors associated with poor HRQoL, univariable and stepwise multivariable regression analysis were performed. RESULTS: A total of 613 survivors completed the questionnaires (response rate: 82.1%; female: 80.1%; median survivorship: 7.4 years (range: 1.0-48.2 years)). The QLQ-C30 summary score mean was 84.4 (standard deviation (SD): 12.7) while the THYCA-QoL summary score mean was 39.9 (SD: 9.7). The 2 highest symptom subscales were fatigue (mean: 26.4, SD: 20.6) and insomnia (mean: 26.2, SD: 27.6). Factors associated with worse HRQoL included serum thyrotropin (TSH) greater than 1.0 mIU/L, unemployment, and concomitant psychiatric disorders. Concomitant psychiatric illness (n = 40/613, 6.5%) also showed significant association with most of the symptom and functional subscales. CONCLUSIONS: Fatigue and insomnia were the 2 most common symptoms experienced by our differentiated thyroid cancer survivors. Long-term survivorship care with monitoring serum TSH level, supporting return-to-work and screening for concomitant psychiatric disorders should be offered.
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spelling pubmed-82523432021-07-13 Health-Related Quality of Life in Asian Differentiated Thyroid Cancer Survivors Chan, Wing-Lok Choi, Horace Cheuk-Wai Lang, Brian Wong, Kai-Pun Yuen, Kwok-Keung Lam, Ka-On Lee, Victor Ho-Fun Kwong, Dora Cancer Control Research Article BACKGROUND: Health-related quality of life (HRQoL) is important for differentiated thyroid cancer survivors, but data for Asian survivors is lacking. This study aimed to have an overview of, and identify any disease-or treatment-related factors associated with, HRQoL in Asian differentiated thyroid cancer survivors. PATIENTS AND METHODS: Thyroid cancer survivors were recruited from the thyroid clinics at Queen Mary Hospital, Hong Kong from February 2016 to December 2016. All adult differentiated thyroid cancer patients with stable disease more than or equal to 1 year received a survey on HRQoL using the European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) and Thyroid cancer specific quality of life (THYCA-QoL) questionnaire. Clinical information was collected retrospectively from the computerized clinical management system. To identify factors associated with poor HRQoL, univariable and stepwise multivariable regression analysis were performed. RESULTS: A total of 613 survivors completed the questionnaires (response rate: 82.1%; female: 80.1%; median survivorship: 7.4 years (range: 1.0-48.2 years)). The QLQ-C30 summary score mean was 84.4 (standard deviation (SD): 12.7) while the THYCA-QoL summary score mean was 39.9 (SD: 9.7). The 2 highest symptom subscales were fatigue (mean: 26.4, SD: 20.6) and insomnia (mean: 26.2, SD: 27.6). Factors associated with worse HRQoL included serum thyrotropin (TSH) greater than 1.0 mIU/L, unemployment, and concomitant psychiatric disorders. Concomitant psychiatric illness (n = 40/613, 6.5%) also showed significant association with most of the symptom and functional subscales. CONCLUSIONS: Fatigue and insomnia were the 2 most common symptoms experienced by our differentiated thyroid cancer survivors. Long-term survivorship care with monitoring serum TSH level, supporting return-to-work and screening for concomitant psychiatric disorders should be offered. SAGE Publications 2021-06-30 /pmc/articles/PMC8252343/ /pubmed/34189945 http://dx.doi.org/10.1177/10732748211029726 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Research Article
Chan, Wing-Lok
Choi, Horace Cheuk-Wai
Lang, Brian
Wong, Kai-Pun
Yuen, Kwok-Keung
Lam, Ka-On
Lee, Victor Ho-Fun
Kwong, Dora
Health-Related Quality of Life in Asian Differentiated Thyroid Cancer Survivors
title Health-Related Quality of Life in Asian Differentiated Thyroid Cancer Survivors
title_full Health-Related Quality of Life in Asian Differentiated Thyroid Cancer Survivors
title_fullStr Health-Related Quality of Life in Asian Differentiated Thyroid Cancer Survivors
title_full_unstemmed Health-Related Quality of Life in Asian Differentiated Thyroid Cancer Survivors
title_short Health-Related Quality of Life in Asian Differentiated Thyroid Cancer Survivors
title_sort health-related quality of life in asian differentiated thyroid cancer survivors
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252343/
https://www.ncbi.nlm.nih.gov/pubmed/34189945
http://dx.doi.org/10.1177/10732748211029726
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