Disentangling Mechanisms Behind Chronic Lethality through Toxicokinetic–Toxicodynamic Modeling

Ecotoxicological profiles of the 3 insecticides imidacloprid, thiacloprid, and flupyradifurone in terms of acute and chronic effects were analyzed in Chironomus riparius. Toxicokinetic–toxicodynamic modeling revealed that chironomids would die from starvation as a result of prolonged feeding inhibit...

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Detalles Bibliográficos
Autores principales: Gergs, André, Hager, Jutta, Bruns, Eric, Preuss, Thomas G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Environmental Toxicology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252366/
https://www.ncbi.nlm.nih.gov/pubmed/33629777
http://dx.doi.org/10.1002/etc.5027
Descripción
Sumario:Ecotoxicological profiles of the 3 insecticides imidacloprid, thiacloprid, and flupyradifurone in terms of acute and chronic effects were analyzed in Chironomus riparius. Toxicokinetic–toxicodynamic modeling revealed that chironomids would die from starvation as a result of prolonged feeding inhibition under chronic exposures. The starvation effect is an indirect cause for mortality, which, for the neonicotinoids, adds to the direct/acute mortality, although the results suggests that this additional effect is not relevant for flupyradifurone. Environ Toxicol Chem 2021;40:1706–1712. © 2021 Bayer Inc. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.

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