Disentangling Mechanisms Behind Chronic Lethality through Toxicokinetic–Toxicodynamic Modeling

Ecotoxicological profiles of the 3 insecticides imidacloprid, thiacloprid, and flupyradifurone in terms of acute and chronic effects were analyzed in Chironomus riparius. Toxicokinetic–toxicodynamic modeling revealed that chironomids would die from starvation as a result of prolonged feeding inhibit...

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Autores principales: Gergs, André, Hager, Jutta, Bruns, Eric, Preuss, Thomas G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Environmental Toxicology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252366/
https://www.ncbi.nlm.nih.gov/pubmed/33629777
http://dx.doi.org/10.1002/etc.5027
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author Gergs, André
Hager, Jutta
Bruns, Eric
Preuss, Thomas G.
author_facet Gergs, André
Hager, Jutta
Bruns, Eric
Preuss, Thomas G.
author_sort Gergs, André
collection PubMed
description Ecotoxicological profiles of the 3 insecticides imidacloprid, thiacloprid, and flupyradifurone in terms of acute and chronic effects were analyzed in Chironomus riparius. Toxicokinetic–toxicodynamic modeling revealed that chironomids would die from starvation as a result of prolonged feeding inhibition under chronic exposures. The starvation effect is an indirect cause for mortality, which, for the neonicotinoids, adds to the direct/acute mortality, although the results suggests that this additional effect is not relevant for flupyradifurone. Environ Toxicol Chem 2021;40:1706–1712. © 2021 Bayer Inc. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
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spelling pubmed-82523662021-07-07 Disentangling Mechanisms Behind Chronic Lethality through Toxicokinetic–Toxicodynamic Modeling Gergs, André Hager, Jutta Bruns, Eric Preuss, Thomas G. Environ Toxicol Chem Environmental Toxicology Ecotoxicological profiles of the 3 insecticides imidacloprid, thiacloprid, and flupyradifurone in terms of acute and chronic effects were analyzed in Chironomus riparius. Toxicokinetic–toxicodynamic modeling revealed that chironomids would die from starvation as a result of prolonged feeding inhibition under chronic exposures. The starvation effect is an indirect cause for mortality, which, for the neonicotinoids, adds to the direct/acute mortality, although the results suggests that this additional effect is not relevant for flupyradifurone. Environ Toxicol Chem 2021;40:1706–1712. © 2021 Bayer Inc. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC. John Wiley and Sons Inc. 2021-05-04 2021-06 /pmc/articles/PMC8252366/ /pubmed/33629777 http://dx.doi.org/10.1002/etc.5027 Text en © 2021 Bayer Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Environmental Toxicology
Gergs, André
Hager, Jutta
Bruns, Eric
Preuss, Thomas G.
Disentangling Mechanisms Behind Chronic Lethality through Toxicokinetic–Toxicodynamic Modeling
title Disentangling Mechanisms Behind Chronic Lethality through Toxicokinetic–Toxicodynamic Modeling
title_full Disentangling Mechanisms Behind Chronic Lethality through Toxicokinetic–Toxicodynamic Modeling
title_fullStr Disentangling Mechanisms Behind Chronic Lethality through Toxicokinetic–Toxicodynamic Modeling
title_full_unstemmed Disentangling Mechanisms Behind Chronic Lethality through Toxicokinetic–Toxicodynamic Modeling
title_short Disentangling Mechanisms Behind Chronic Lethality through Toxicokinetic–Toxicodynamic Modeling
title_sort disentangling mechanisms behind chronic lethality through toxicokinetic–toxicodynamic modeling
topic Environmental Toxicology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252366/
https://www.ncbi.nlm.nih.gov/pubmed/33629777
http://dx.doi.org/10.1002/etc.5027
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