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Cytoarchitecture and innervation of the mouse cochlear amplifier revealed by large‐scale volume electron microscopy
In mammalian cochlea, sound‐induced vibration is amplified by a three‐row lattice of Y‐shaped microstructures consisting of electromotile outer hair cell and supporting Deiters cell. This highly organized structure is thought to be essential for hearing of low‐level sounds. Prior studies reported di...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252425/ https://www.ncbi.nlm.nih.gov/pubmed/33719053 http://dx.doi.org/10.1002/cne.25137 |
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author | Wang, Haoyu Wang, Shengxiong Lu, Yan Chen, Ying Huang, Wenqing Qiu, Miaoxin Wu, Hao Hua, Yunfeng |
author_facet | Wang, Haoyu Wang, Shengxiong Lu, Yan Chen, Ying Huang, Wenqing Qiu, Miaoxin Wu, Hao Hua, Yunfeng |
author_sort | Wang, Haoyu |
collection | PubMed |
description | In mammalian cochlea, sound‐induced vibration is amplified by a three‐row lattice of Y‐shaped microstructures consisting of electromotile outer hair cell and supporting Deiters cell. This highly organized structure is thought to be essential for hearing of low‐level sounds. Prior studies reported differences in geometry and synaptic innervation of the outer hair cells between rows, but how these fine features are achieved at subcellular level still remains unclear. Using serial block‐face electron microscopy, we acquired few‐hundred‐micron‐sized cytoarchitecture of mouse organ of Corti at nanometer resolution. Structural quantifications were performed on the Y‐shapes as well as afferent and efferent projections to outer hair cells (OHCs). Several new features, which support the previously observed inter‐row heterogeneity, are described. Our result provides structural bases for the gradient of mechanical properties and diverse centrifugal regulation of OHC rows. |
format | Online Article Text |
id | pubmed-8252425 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82524252021-07-07 Cytoarchitecture and innervation of the mouse cochlear amplifier revealed by large‐scale volume electron microscopy Wang, Haoyu Wang, Shengxiong Lu, Yan Chen, Ying Huang, Wenqing Qiu, Miaoxin Wu, Hao Hua, Yunfeng J Comp Neurol Research Articles In mammalian cochlea, sound‐induced vibration is amplified by a three‐row lattice of Y‐shaped microstructures consisting of electromotile outer hair cell and supporting Deiters cell. This highly organized structure is thought to be essential for hearing of low‐level sounds. Prior studies reported differences in geometry and synaptic innervation of the outer hair cells between rows, but how these fine features are achieved at subcellular level still remains unclear. Using serial block‐face electron microscopy, we acquired few‐hundred‐micron‐sized cytoarchitecture of mouse organ of Corti at nanometer resolution. Structural quantifications were performed on the Y‐shapes as well as afferent and efferent projections to outer hair cells (OHCs). Several new features, which support the previously observed inter‐row heterogeneity, are described. Our result provides structural bases for the gradient of mechanical properties and diverse centrifugal regulation of OHC rows. John Wiley & Sons, Inc. 2021-03-18 2021-08-01 /pmc/articles/PMC8252425/ /pubmed/33719053 http://dx.doi.org/10.1002/cne.25137 Text en © 2021 The Authors. The Journal of Comparative Neurology published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Wang, Haoyu Wang, Shengxiong Lu, Yan Chen, Ying Huang, Wenqing Qiu, Miaoxin Wu, Hao Hua, Yunfeng Cytoarchitecture and innervation of the mouse cochlear amplifier revealed by large‐scale volume electron microscopy |
title | Cytoarchitecture and innervation of the mouse cochlear amplifier revealed by large‐scale volume electron microscopy |
title_full | Cytoarchitecture and innervation of the mouse cochlear amplifier revealed by large‐scale volume electron microscopy |
title_fullStr | Cytoarchitecture and innervation of the mouse cochlear amplifier revealed by large‐scale volume electron microscopy |
title_full_unstemmed | Cytoarchitecture and innervation of the mouse cochlear amplifier revealed by large‐scale volume electron microscopy |
title_short | Cytoarchitecture and innervation of the mouse cochlear amplifier revealed by large‐scale volume electron microscopy |
title_sort | cytoarchitecture and innervation of the mouse cochlear amplifier revealed by large‐scale volume electron microscopy |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252425/ https://www.ncbi.nlm.nih.gov/pubmed/33719053 http://dx.doi.org/10.1002/cne.25137 |
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