Decarboxylative Polyfluoroarylation of Alkylcarboxylic Acids

Polyfluoroarenes are useful building blocks in several areas such as drug discovery, materials, and crop protection. Herein, we report the first polyfluoroarylation of aliphatic carboxylic acids via photoredox decarboxylation. The method proceeds with broad substrate scope and high functional group...

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Detalles Bibliográficos
Autores principales: Sun, Xiang, Ritter, Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252513/
https://www.ncbi.nlm.nih.gov/pubmed/33481305
http://dx.doi.org/10.1002/anie.202015596
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author Sun, Xiang
Ritter, Tobias
author_facet Sun, Xiang
Ritter, Tobias
author_sort Sun, Xiang
collection PubMed
description Polyfluoroarenes are useful building blocks in several areas such as drug discovery, materials, and crop protection. Herein, we report the first polyfluoroarylation of aliphatic carboxylic acids via photoredox decarboxylation. The method proceeds with broad substrate scope and high functional group tolerance. Moreover, small complex molecules such as natural products and drugs can be modified by late‐stage modification.
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spelling pubmed-82525132021-07-09 Decarboxylative Polyfluoroarylation of Alkylcarboxylic Acids Sun, Xiang Ritter, Tobias Angew Chem Int Ed Engl Communications Polyfluoroarenes are useful building blocks in several areas such as drug discovery, materials, and crop protection. Herein, we report the first polyfluoroarylation of aliphatic carboxylic acids via photoredox decarboxylation. The method proceeds with broad substrate scope and high functional group tolerance. Moreover, small complex molecules such as natural products and drugs can be modified by late‐stage modification. John Wiley and Sons Inc. 2021-03-30 2021-05-03 /pmc/articles/PMC8252513/ /pubmed/33481305 http://dx.doi.org/10.1002/anie.202015596 Text en © 2021 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Communications
Sun, Xiang
Ritter, Tobias
Decarboxylative Polyfluoroarylation of Alkylcarboxylic Acids
title Decarboxylative Polyfluoroarylation of Alkylcarboxylic Acids
title_full Decarboxylative Polyfluoroarylation of Alkylcarboxylic Acids
title_fullStr Decarboxylative Polyfluoroarylation of Alkylcarboxylic Acids
title_full_unstemmed Decarboxylative Polyfluoroarylation of Alkylcarboxylic Acids
title_short Decarboxylative Polyfluoroarylation of Alkylcarboxylic Acids
title_sort decarboxylative polyfluoroarylation of alkylcarboxylic acids
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252513/
https://www.ncbi.nlm.nih.gov/pubmed/33481305
http://dx.doi.org/10.1002/anie.202015596
work_keys_str_mv AT sunxiang decarboxylativepolyfluoroarylationofalkylcarboxylicacids
AT rittertobias decarboxylativepolyfluoroarylationofalkylcarboxylicacids

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