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Plant stem cell research is uncovering the secrets of longevity and persistent growth

Plant stem cells have several extraordinary features: they are generated de novo during development and regeneration, maintain their pluripotency, and produce another stem cell niche in an orderly manner. This enables plants to survive for an extended period and to continuously make new organs, repr...

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Autores principales: Umeda, Masaaki, Ikeuchi, Momoko, Ishikawa, Masaki, Ito, Toshiro, Nishihama, Ryuichi, Kyozuka, Junko, Torii, Keiko U., Satake, Akiko, Goshima, Gohta, Sakakibara, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252613/
https://www.ncbi.nlm.nih.gov/pubmed/33533118
http://dx.doi.org/10.1111/tpj.15184
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author Umeda, Masaaki
Ikeuchi, Momoko
Ishikawa, Masaki
Ito, Toshiro
Nishihama, Ryuichi
Kyozuka, Junko
Torii, Keiko U.
Satake, Akiko
Goshima, Gohta
Sakakibara, Hitoshi
author_facet Umeda, Masaaki
Ikeuchi, Momoko
Ishikawa, Masaki
Ito, Toshiro
Nishihama, Ryuichi
Kyozuka, Junko
Torii, Keiko U.
Satake, Akiko
Goshima, Gohta
Sakakibara, Hitoshi
author_sort Umeda, Masaaki
collection PubMed
description Plant stem cells have several extraordinary features: they are generated de novo during development and regeneration, maintain their pluripotency, and produce another stem cell niche in an orderly manner. This enables plants to survive for an extended period and to continuously make new organs, representing a clear difference in their developmental program from animals. To uncover regulatory principles governing plant stem cell characteristics, our research project ‘Principles of pluripotent stem cells underlying plant vitality’ was launched in 2017, supported by a Grant‐in‐Aid for Scientific Research on Innovative Areas from the Japanese government. Through a collaboration involving 28 research groups, we aim to identify key factors that trigger epigenetic reprogramming and global changes in gene networks, and thereby contribute to stem cell generation. Pluripotent stem cells in the shoot apical meristem are controlled by cytokinin and auxin, which also play a crucial role in terminating stem cell activity in the floral meristem; therefore, we are focusing on biosynthesis, metabolism, transport, perception, and signaling of these hormones. Besides, we are uncovering the mechanisms of asymmetric cell division and of stem cell death and replenishment under DNA stress, which will illuminate plant‐specific features in preserving stemness. Our technology support groups expand single‐cell omics to describe stem cell behavior in a spatiotemporal context, and provide correlative light and electron microscopic technology to enable live imaging of cell and subcellular dynamics at high spatiotemporal resolution. In this perspective, we discuss future directions of our ongoing projects and related research fields.
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spelling pubmed-82526132021-07-09 Plant stem cell research is uncovering the secrets of longevity and persistent growth Umeda, Masaaki Ikeuchi, Momoko Ishikawa, Masaki Ito, Toshiro Nishihama, Ryuichi Kyozuka, Junko Torii, Keiko U. Satake, Akiko Goshima, Gohta Sakakibara, Hitoshi Plant J Perspective Plant stem cells have several extraordinary features: they are generated de novo during development and regeneration, maintain their pluripotency, and produce another stem cell niche in an orderly manner. This enables plants to survive for an extended period and to continuously make new organs, representing a clear difference in their developmental program from animals. To uncover regulatory principles governing plant stem cell characteristics, our research project ‘Principles of pluripotent stem cells underlying plant vitality’ was launched in 2017, supported by a Grant‐in‐Aid for Scientific Research on Innovative Areas from the Japanese government. Through a collaboration involving 28 research groups, we aim to identify key factors that trigger epigenetic reprogramming and global changes in gene networks, and thereby contribute to stem cell generation. Pluripotent stem cells in the shoot apical meristem are controlled by cytokinin and auxin, which also play a crucial role in terminating stem cell activity in the floral meristem; therefore, we are focusing on biosynthesis, metabolism, transport, perception, and signaling of these hormones. Besides, we are uncovering the mechanisms of asymmetric cell division and of stem cell death and replenishment under DNA stress, which will illuminate plant‐specific features in preserving stemness. Our technology support groups expand single‐cell omics to describe stem cell behavior in a spatiotemporal context, and provide correlative light and electron microscopic technology to enable live imaging of cell and subcellular dynamics at high spatiotemporal resolution. In this perspective, we discuss future directions of our ongoing projects and related research fields. John Wiley and Sons Inc. 2021-03-25 2021-04 /pmc/articles/PMC8252613/ /pubmed/33533118 http://dx.doi.org/10.1111/tpj.15184 Text en © 2021 The Authors. The Plant Journal published by Society for Experimental Biology and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Perspective
Umeda, Masaaki
Ikeuchi, Momoko
Ishikawa, Masaki
Ito, Toshiro
Nishihama, Ryuichi
Kyozuka, Junko
Torii, Keiko U.
Satake, Akiko
Goshima, Gohta
Sakakibara, Hitoshi
Plant stem cell research is uncovering the secrets of longevity and persistent growth
title Plant stem cell research is uncovering the secrets of longevity and persistent growth
title_full Plant stem cell research is uncovering the secrets of longevity and persistent growth
title_fullStr Plant stem cell research is uncovering the secrets of longevity and persistent growth
title_full_unstemmed Plant stem cell research is uncovering the secrets of longevity and persistent growth
title_short Plant stem cell research is uncovering the secrets of longevity and persistent growth
title_sort plant stem cell research is uncovering the secrets of longevity and persistent growth
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252613/
https://www.ncbi.nlm.nih.gov/pubmed/33533118
http://dx.doi.org/10.1111/tpj.15184
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