Macrocyclic FKBP51 Ligands Define a Transient Binding Mode with Enhanced Selectivity

Subtype selectivity represents a challenge in many drug discovery campaigns. A typical example is the FK506 binding protein 51 (FKBP51), which has emerged as an attractive drug target. The most advanced FKBP51 ligands of the SAFit class are highly selective vs. FKBP52 but poorly discriminate against...

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Detalles Bibliográficos
Autores principales: Voll, Andreas M., Meyners, Christian, Taubert, Martha C., Bajaj, Thomas, Heymann, Tim, Merz, Stephanie, Charalampidou, Anna, Kolos, Jürgen, Purder, Patrick L., Geiger, Thomas M., Wessig, Pablo, Gassen, Nils C., Bracher, Andreas, Hausch, Felix
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252719/
https://www.ncbi.nlm.nih.gov/pubmed/33843131
http://dx.doi.org/10.1002/anie.202017352

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252719/
https://www.ncbi.nlm.nih.gov/pubmed/33843131
http://dx.doi.org/10.1002/anie.202017352

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