Cargando…

(2‐Ethylhexyl)sodium: A Hexane‐Soluble Reagent for Br/Na‐Exchanges and Directed Metalations in Continuous Flow

We report the on‐demand generation of hexane‐soluble (2‐ethylhexyl)sodium (1) from 3‐(chloromethyl)heptane (2) using a sodium‐packed‐bed reactor under continuous flow conditions. Thus, the resulting solution of 1 is free of elemental sodium and therefore suited for a range of synthetic applications....

Descripción completa

Detalles Bibliográficos
Autores principales:	Harenberg, Johannes H., Weidmann, Niels, Wiegand, Alexander J., Hoefer, Carla A., Annapureddy, Rajasekar Reddy, Knochel, Paul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252725/ https://www.ncbi.nlm.nih.gov/pubmed/33826212 http://dx.doi.org/10.1002/anie.202103031

Ejemplares similares

Continuous Flow Preparation of Benzylic Sodium Organometallics
por: Harenberg, Johannes H., et al.
Publicado: (2022)

Preparation of Functionalized Aryl, Heteroaryl, and Benzylic Potassium Organometallics Using Potassium Diisopropylamide in Continuous Flow
por: Harenberg, Johannes H., et al.
Publicado: (2020)

In Situ Quench Reactions of Enantioenriched Secondary Alkyllithium Reagents in Batch and Continuous Flow Using an I/Li‐Exchange
por: Kremsmair, Alexander, et al.
Publicado: (2022)

Continuous Flow Sodiation of Substituted Acrylonitriles, Alkenyl Sulfides and Acrylates
por: Harenberg, Johannes H., et al.
Publicado: (2020)

Modification of cardiac sodium channels by carboxyl reagents. Trimethyloxonium and water-soluble carbodiimide
Publicado: (1993)

NA60 and BR scaling
por: Skokov, V V, et al.
Publicado: (2005)

Sodium-calcium exchange current. Dependence on internal Ca and Na and competitive binding of external Na and Ca
Publicado: (1989)

Diastereo‐ and Enantioselective Cross‐Couplings of Secondary Alkylcopper Reagents with 3‐Halogeno‐Unsaturated Carbonyl Derivatives
por: Kremsmair, Alexander, et al.
Publicado: (2020)

The solubility behavior of sodium arsenate in NaOH solution based on the Pitzer model
por: Song, Kun, et al.
Publicado: (2023)

Di(2-ethylhexyl) adipate
Publicado: (1982)

Comparison of hepatic peroxisome proliferative effect and its implication for hepatocarcinogenicity of phthalate esters, di(2-ethylhexyl) phthalate, and di(2-ethylhexyl) adipate with a hypolipidemic drug.
por: Reddy, J K, et al.
Publicado: (1986)

Finding the Right Blend: Interplay Between Structure and Sodium Ion Conductivity in the System Na(5)AlS(4)–Na(4)SiS(4)
por: Harm, Sascha, et al.
Publicado: (2020)

Pyrrole‐Protected β‐Aminoalkylzinc Reagents for the Enantioselective Synthesis of Amino‐Derivatives
por: Leroux, Marcel, et al.
Publicado: (2020)

Acidic Gases Solubility in Bis(2-Ethylhexyl) Sulfosuccinate Based Ionic Liquids Using the Predictive Thermodynamic Model
por: Mechergui, Amal, et al.
Publicado: (2020)

Unraveling the Bonding Complexity of Polyhalogen Anions: High-Pressure Synthesis of Unpredicted Sodium Chlorides Na(2)Cl(3) and Na(4)Cl(5) and Bromide Na(4)Br(5)
por: Yin, Yuqing, et al.
Publicado: (2023)

Functionalization of heterocyclic compounds using polyfunctional magnesium and zinc reagents
por: Knochel, Paul, et al.
Publicado: (2011)

Cobalt‐Catalyzed Cross‐Coupling of Functionalized Alkylzinc Reagents with (Hetero)Aryl Halides
por: Lutter, Ferdinand H., et al.
Publicado: (2020)

Benzyl 2-ethylhexyl sulfoxide
por: Zhi-Guang, Xu, et al.
Publicado: (2009)

Solid-liquid equilibria in relevant subsystems of LiBr-NaBr-KBr-MgBr(2)-CaBr(2)-H(2)O system at 298.15 K
por: Cui, Ruizhi, et al.
Publicado: (2023)

Silver‐Catalyzed Enantioselective Sulfimidation Mediated by Hydrogen Bonding Interactions
por: Annapureddy, Rajasekar Reddy, et al.
Publicado: (2021)

Recent Advances of the Halogen–Zinc Exchange Reaction
por: Balkenhohl, Moritz, et al.
Publicado: (2020)

Water-Soluble Electrospun Nanofibers as a Method for On-Chip Reagent Storage
por: Dai, Minhui, et al.
Publicado: (2012)

Stable Na Electrodeposition Enabled by Agarose-Based Water-Soluble Sodium Ion Battery Separators
por: Ojanguren, Alazne, et al.
Publicado: (2021)

Hexane and carbon disulfide.
Publicado: (1994)

Electrogenic Sodium–Sodium Exchange Carried Out by Na,k -Atpase Containing the Amino Acid Substitution Glu779ala
por: Peluffo, R. Daniel, et al.
Publicado: (2000)

Hexane soluble extract of Mallotus philippensis (Lam.) Muell. Arg. root possesses anti-leukaemic activity
por: Khan, Musa, et al.
Publicado: (2013)

Antiproliferative property of n-hexane and chloroform extracts of Anisomeles malabarica (L). R. Br. in HPV16-positive human cervical cancer cells
por: Preethy, Christo Paul, et al.
Publicado: (2012)

Transition‐Metal‐Free Synthesis of Polyfunctional Triarylmethanes and 1,1‐Diarylalkanes by Sequential Cross‐Coupling of Benzal Diacetates with Organozinc Reagents
por: Wei, Baosheng, et al.
Publicado: (2021)

General stereoretentive preparation of chiral secondary mixed alkylmagnesium reagents and their use for enantioselective electrophilic aminations
por: Kremsmair, Alexander, et al.
Publicado: (2021)

Risk Assessment of Ethylhexyl Dimethyl PABA in Cosmetics
por: Sung, Chi Rim, et al.
Publicado: (2019)

Formation of chlorinated breakdown products during degradation of sunscreen agent, 2-ethylhexyl-4-methoxycinnamate in the presence of sodium hypochlorite
por: Gackowska, Alicja, et al.
Publicado: (2015)

The in vitro serum protein-binding characteristics of bis-(2-ethylhexyl) phthalate and its principal metabolite, mono-(2-ethylhexyl) phthalate.
por: Griffiths, W C, et al.
Publicado: (1988)

Comparative Effects of Di-(2-ethylhexyl)phthalate and Di-(2-ethylhexyl)terephthalate Metabolites on Thyroid Receptors: In Vitro and In Silico Studies
por: Kambia, Nicolas, et al.
Publicado: (2021)

The Na(+)/H(+) exchanger in metastasis
por: Amith, Schammim Ray, et al.
Publicado: (2016)

Irreversible inactivation of red cell chloride exchange with phenylglyoxal, and arginine-specific reagent
Publicado: (1982)

Copper-catalyzed formylation of alkenyl C–H bonds using BrCHCl(2) as a stoichiometric formylating reagent
por: Bao, Yan, et al.
Publicado: (2018)

Slow sodium inactivation in nerve after exposure to sulhydryl blocking reagents
Publicado: (1977)

Effects of Hexane on Protein Profile, Solubility and Foaming Properties of Defatted Proteins Extracted from Tenebrio molitor Larvae
por: Gravel, Alexia, et al.
Publicado: (2021)

Sodium-calcium exchange /
Publicado: (1991)

Sodium-calcium exchange /
Publicado: (1989)

Cannot write session to /tmp/vufind_sessions/sess_inth4rf20n4deklct9use5gbi1