Chemical Evolution of Antivirals Against Enterovirus D68 through Protein‐Templated Knoevenagel Reactions

The generation of bioactive molecules from inactive precursors is a crucial step in the chemical evolution of life, however, mechanistic insights into this aspect of abiogenesis are scarce. Here, we investigate the protein‐catalyzed formation of antivirals by the 3C‐protease of enterovirus D68. The...

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Detalles Bibliográficos
Autores principales: Tauber, Carolin, Wamser, Rebekka, Arkona, Christoph, Tügend, Marisa, Abdul Aziz, Umer Bin, Pach, Szymon, Schulz, Robert, Jochmans, Dirk, Wolber, Gerhard, Neyts, Johan, Rademann, Jörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252737/
https://www.ncbi.nlm.nih.gov/pubmed/33749121
http://dx.doi.org/10.1002/anie.202102074

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252737/
https://www.ncbi.nlm.nih.gov/pubmed/33749121
http://dx.doi.org/10.1002/anie.202102074

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