Dynamic Protease Activation on a Multimeric Synthetic Protein Scaffold via Adaptable DNA‐Based Recruitment Domains

Hexameric hemoprotein (HTHP) is employed as a scaffold protein for the supramolecular assembly and activation of the apoptotic signalling enzyme caspase‐9, using short DNA elements as modular recruitment domains. Caspase‐9 assembly and activation on the HTHP platform due to enhanced proximity is fol...

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Detalles Bibliográficos
Autores principales: Mashima, Tsuyoshi, Rosier, Bas J. H. M., Oohora, Koji, de Greef, Tom F. A., Hayashi, Takashi, Brunsveld, Luc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252739/
https://www.ncbi.nlm.nih.gov/pubmed/33725379
http://dx.doi.org/10.1002/anie.202102160

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