Classification of high‐grade cervical intraepithelial neoplasia by p16(ink4a), Ki‐67, HPV E4 and FAM19A4/miR124‐2 methylation status demonstrates considerable heterogeneity with potential consequences for management

High‐grade cervical intraepithelial neoplasia (CIN2 and CIN3) represents a heterogeneous disease with varying cancer progression risks. Biomarkers indicative for a productive human papillomavirus (HPV) infection (HPV E4) and a transforming HPV infection (p16(ink4a), Ki‐67 and host‐cell DNA methylati...

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Detalles Bibliográficos
Autores principales: Vink, Frederique J., Dick, Stèfanie, Heideman, Daniëlle A. M., De Strooper, Lise M. A., Steenbergen, Renske D. M., Lissenberg‐Witte, Birgit I., Floore, Arno, Bonde, Jesper H., Oštrbenk Valenčak, Anja, Poljak, Mario, Petry, Karl U., Hillemanns, Peter, van Trommel, Nienke E., Berkhof, Johannes, Bleeker, Maaike C. G., Meijer, Chris J. L. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Tumor Markers and Signatures
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252755/
https://www.ncbi.nlm.nih.gov/pubmed/33729551
http://dx.doi.org/10.1002/ijc.33566

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