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Signaling at the endosome: cryo‐EM structure of a GPCR–G protein–beta‐arrestin megacomplex
G protein‐coupled receptors (GPCRs) are a large class of cell‐surface receptor involved in cellular signaling that are currently the target of over one third of all clinically approved therapeutics. Classically, an agonist‐bound, active GPCR couples to and activates G proteins through the receptor i...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252779/ https://www.ncbi.nlm.nih.gov/pubmed/33605032 http://dx.doi.org/10.1111/febs.15773 |