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Red cell transfusion and alloimmunization in sickle cell disease

Red cell transfusion remains a critical component of care for acute and chronic complications of sickle cell disease. Randomized clinical trials demonstrated the benefits of transfusion therapy for prevention of primary and secondary strokes and postoperative acute chest syndrome. Transfusion for sp...

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Detalles Bibliográficos
Autores principales: Linder, Grace E., Chou, Stella T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252926/
https://www.ncbi.nlm.nih.gov/pubmed/33792218
http://dx.doi.org/10.3324/haematol.2020.270546
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author Linder, Grace E.
Chou, Stella T.
author_facet Linder, Grace E.
Chou, Stella T.
author_sort Linder, Grace E.
collection PubMed
description Red cell transfusion remains a critical component of care for acute and chronic complications of sickle cell disease. Randomized clinical trials demonstrated the benefits of transfusion therapy for prevention of primary and secondary strokes and postoperative acute chest syndrome. Transfusion for splenic sequestration, acute chest syndrome, and acute stroke are guided by expert consensus recommendations. Despite overall improvements in blood inventory safety, adverse effects of transfusion are prevalent among patients with sickle cell disease and include alloimmunization, acute and delayed hemolytic transfusion reactions, and iron overload. Judicious use of red cell transfusions, optimization of red cell antigen matching, and the use of erythrocytapheresis and iron chelation can minimize adverse effects. Early recognition and management of hemolytic transfusion reactions can avert poor clinical outcomes. In this review, we discuss transfusion methods, indications, and complications in sickle cell disease with an emphasis on alloimmunization.
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spelling pubmed-82529262021-07-14 Red cell transfusion and alloimmunization in sickle cell disease Linder, Grace E. Chou, Stella T. Haematologica Review Article Red cell transfusion remains a critical component of care for acute and chronic complications of sickle cell disease. Randomized clinical trials demonstrated the benefits of transfusion therapy for prevention of primary and secondary strokes and postoperative acute chest syndrome. Transfusion for splenic sequestration, acute chest syndrome, and acute stroke are guided by expert consensus recommendations. Despite overall improvements in blood inventory safety, adverse effects of transfusion are prevalent among patients with sickle cell disease and include alloimmunization, acute and delayed hemolytic transfusion reactions, and iron overload. Judicious use of red cell transfusions, optimization of red cell antigen matching, and the use of erythrocytapheresis and iron chelation can minimize adverse effects. Early recognition and management of hemolytic transfusion reactions can avert poor clinical outcomes. In this review, we discuss transfusion methods, indications, and complications in sickle cell disease with an emphasis on alloimmunization. Fondazione Ferrata Storti 2021-04-01 /pmc/articles/PMC8252926/ /pubmed/33792218 http://dx.doi.org/10.3324/haematol.2020.270546 Text en Copyright© 2021 Ferrata Storti Foundation https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution Noncommercial License (by-nc 4.0) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Review Article
Linder, Grace E.
Chou, Stella T.
Red cell transfusion and alloimmunization in sickle cell disease
title Red cell transfusion and alloimmunization in sickle cell disease
title_full Red cell transfusion and alloimmunization in sickle cell disease
title_fullStr Red cell transfusion and alloimmunization in sickle cell disease
title_full_unstemmed Red cell transfusion and alloimmunization in sickle cell disease
title_short Red cell transfusion and alloimmunization in sickle cell disease
title_sort red cell transfusion and alloimmunization in sickle cell disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252926/
https://www.ncbi.nlm.nih.gov/pubmed/33792218
http://dx.doi.org/10.3324/haematol.2020.270546
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