Halting the vicious cycle within the multiple myeloma ecosystem: blocking JAM-A on bone marrow endothelial cells restores angiogenic homeostasis and suppresses tumor progression

Interactions of malignant multiple myeloma (MM) plasma cells with the microenvironment control MM plasma-cell growth, survival, drug-resistance and dissemination. As microvascular density increases in the bone marrow in MM, we investigated whether bone marrow MM endothelial cells control disease pro...

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Detalles Bibliográficos
Autores principales: Solimando, Antonio G., Da Viá, Matteo C., Leone, Patrizia, Borrelli, Paola, Croci, Giorgio A., Tabares, Paula, Brandl, Andreas, Di Lernia, Giuseppe, Bianchi, Francesco P., Tafuri, Silvio, Steinbrunn, Torsten, Balduini, Alessandra, Melaccio, Assunta, De Summa, Simona, Argentiero, Antonella, Rauert-Wunderlich, Hilka, Frassanito, Maria A., Ditonno, Paolo, Henke, Erik, Klapper, Wolfram, Ria, Roberto, Terragna, Carolina, Rasche, Leo, Rosenwald, Andreas, Kortüm, K. Martin, Cavo, Michele, Ribatti, Domenico, Racanelli, Vito, Einsele, Hermann, Vacca, Angelo, Beilhack, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252928/
https://www.ncbi.nlm.nih.gov/pubmed/32354870
http://dx.doi.org/10.3324/haematol.2019.239913

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