WEE1 inhibition induces glutamine addiction in T-cell acute lymphoblastic leukemia

Tcell acute lymphoblastic leukemias (T-ALL) are aggressive and heterogeneous hematologic tumors resulting from the malignant transformation of T-cell progenitors. The major challenges in the treatment of T-ALL are dose-limiting toxicities of chemotherapeutics and drug resistance. Despite important p...

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Detalles Bibliográficos
Autores principales: Hu, Juncheng, Wang, Tianci, Xu, Jin, Wu, Sanyun, Wang, Liyuan, Su, Hexiu, Jiang, Jue, Yue, Ming, Wang, Jingchao, Wang, Donghai, Li, Peng, Zhou, Fuling, Liu, Yu, Qing, Guoliang, Liu, Hudan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252940/
https://www.ncbi.nlm.nih.gov/pubmed/31919076
http://dx.doi.org/10.3324/haematol.2019.231126

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