Cargando…

Thrombopoietin maintains cell numbers of hematopoietic stem and progenitor cells with megakaryopoietic potential

Thrombopoietin has long been known to influence megakaryopoiesis and hematopoietic stem and progenitor cells, although the exact mechanisms through which it acts are unknown. Here we show that MPL expression correlates with megakaryopoietic potential of hematopoietic stem and progenitor cells and id...

Descripción completa

Detalles Bibliográficos
Autores principales:	O’Neill, Aled, Chin, Desmond, Tan, Darren, Majeed, A’Qilah Banu Bte Abdul, Nakamura-Ishizu, Ayako, Suda, Toshio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Fondazione Ferrata Storti 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252958/ https://www.ncbi.nlm.nih.gov/pubmed/32527954 http://dx.doi.org/10.3324/haematol.2019.241406

Ejemplares similares

The Road Map for Megakaryopoietic Lineage from Hematopoietic Stem/Progenitor Cells
por: Nishikii, Hidekazu, et al.
Publicado: (2017)

Lymphoid-biased hematopoietic stem cells and myeloid-biased hematopoietic progenitor cells have radioprotection activity
por: Zhang, Shanshan, et al.
Publicado: (2021)

Mitochondria Turnover and Lysosomal Function in Hematopoietic Stem Cell Metabolism
por: Mochizuki-Kashio, Makiko, et al.
Publicado: (2021)

Ca(2+)–mitochondria axis drives cell division in hematopoietic stem cells
por: Umemoto, Terumasa, et al.
Publicado: (2018)

Designer Cytokine Hyper Interleukin 11 (H11) is a Megakaryopoietic Factor
por: Dams-Kozlowska, Hanna, et al.
Publicado: (2013)

Thrombopoietin enhances hematopoietic stem and progenitor cell homing by impeding matrix metalloproteinase 9 expression
por: Liu, Yiming, et al.
Publicado: (2020)

CLEC-2 in megakaryocytes is critical for maintenance of hematopoietic stem cells in the bone marrow
por: Nakamura-Ishizu, Ayako, et al.
Publicado: (2015)

Correction: CLEC-2 in megakaryocytes is critical for maintenance of hematopoietic stem cells in the bone marrow
por: Nakamura-Ishizu, Ayako, et al.
Publicado: (2015)

The arginase inhibitor N(ω)−hydroxy−nor−arginine (nor−NOHA) induces apoptosis in leukemic cells specifically under hypoxic conditions but CRISPR/Cas9 excludes arginase 2 (ARG2) as the functional target
por: Ng, King Pan, et al.
Publicado: (2018)

Hematopoietic stem cells temporally transition to thrombopoietin dependence in the fetal liver
por: Lee, Yeojin, et al.
Publicado: (2022)

Thrombopoietin from hepatocytes promotes hematopoietic stem cell regeneration after myeloablation
por: Gao, Longfei, et al.
Publicado: (2021)

Low-dose ionizing radiations leave scars on human hematopoietic stem and progenitor cells: the role of reactive oxygen species
por: Yamashita, Masayuki, et al.
Publicado: (2021)

miR-486-5p and miR-22-3p Enable Megakaryocytic Differentiation of Hematopoietic Stem and Progenitor Cells without Thrombopoietin
por: Kao, Chen-Yuan, et al.
Publicado: (2022)

The thrombopoietin receptor, c-Mpl, is a selective surface marker for human hematopoietic stem cells
por: Ninos, John M, et al.
Publicado: (2006)

Thrombopoietin protects hematopoietic stem cells from retrotransposon-mediated damage by promoting an antiviral response
por: Barbieri, Daniela, et al.
Publicado: (2018)

Recombinant human thrombopoietin promotes hematopoietic reconstruction after severe whole body irradiation
por: Wang, Chao, et al.
Publicado: (2015)

Inhibition of Thrombopoietin/Mpl Signaling in Adult Hematopoiesis Identifies New Candidates for Hematopoietic Stem Cell Maintenance
por: Kohlscheen, Saskia, et al.
Publicado: (2015)

Deciphering the Differential Impact of Thrombopoietin/MPL Signaling on Hematopoietic Stem Cell Function in Bone Marrow and Spleen
por: Lee, Sandy, et al.
Publicado: (2023)

Tsukushi proteoglycan maintains RNA splicing and developmental signaling network in GFAP-expressing subventricular zone neural stem/progenitor cells
por: Istiaq, Arif, et al.
Publicado: (2022)

Drosophila E-Cadherin Functions in Hematopoietic Progenitors to Maintain Multipotency and Block Differentiation
por: Gao, Hongjuan, et al.
Publicado: (2013)

RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells
por: Herrejon Chavez, Florisela, et al.
Publicado: (2023)

Overproduction of thrombopoietin by BRAFV600E‐mutated mouse hepatocytes and contribution of thrombopoietin to hepatocarcinogenesis
por: Tanaka, Hiroki, et al.
Publicado: (2019)

Hlf marks the developmental pathway for hematopoietic stem cells but not for erythro-myeloid progenitors
por: Yokomizo, Tomomasa, et al.
Publicado: (2019)

P1397: CHRONICALLY REDUCED LEVELS OF THROMBOPOIETIN IMPAIR HEMATOPOIETIC STEM CELL FUNCTION AND MEGAKARYOCYTE BONE MARROW NICHE
por: Aprile, A., et al.
Publicado: (2022)

Thrombopoietin Secretion by Human Ovarian Cancer Cells
por: Besbes, Samaher, et al.
Publicado: (2017)

Thrombopoietin: tickling the HSC's fancy
por: Kim, Ah Ram, et al.
Publicado: (2017)

DNA methyltransferase 1 functions through C/ebpa to maintain hematopoietic stem and progenitor cells in zebrafish
por: Liu, Xiaohui, et al.
Publicado: (2015)

Mitigation of total body irradiation-induced mortality and hematopoietic injury of mice by a thrombopoietin mimetic (JNJ-26366821)
por: Kumar, Vidya P., et al.
Publicado: (2022)

Matrix Gla protein maintains normal and malignant hematopoietic progenitor cells by interacting with bone morphogenetic protein-4
por: Kuronuma, Kana, et al.
Publicado: (2020)

Hematopoietic cells maintain hematopoietic fates upon entering the brain
por: Massengale, Mei, et al.
Publicado: (2005)

In and out: Traffic and dynamics of thrombopoietin receptor
por: Roy, Anita, et al.
Publicado: (2021)

The Spindle Assembly Checkpoint Is Required for Hematopoietic Progenitor Cell Engraftment
por: Brown, Andreas, et al.
Publicado: (2017)

Icaritin Provokes Serum Thrombopoietin and Downregulates Thrombopoietin/MPL of the Bone Marrow in a Mouse Model of Immune Thrombocytopenia
por: Zhang, Ke, et al.
Publicado: (2018)

Differential cytokine effects on primitive (CD34+CD38-) human hematopoietic cells: novel responses to Flt3-ligand and thrombopoietin
Publicado: (1996)

Recombinant human thrombopoietin improved platelet engraftment after autologous hematopoietic stem cell transplantation in patients with newly diagnosed multiple myeloma
por: Gu, Jingli, et al.
Publicado: (2021)

Thrombopoietin Receptor Levels in Tumor Cell Lines and Primary Tumors
por: Erickson-Miller, Connie L., et al.
Publicado: (2010)

PB2425: EFFICACY AND SAFETY OF COMBINED THERAPY OF RECOMBINANT HUMAN THROMBOPOIETIN AND ELTROMBOPAG FOR TREATMENT OF PERSISTENT THROMBOCYTOPENIA AFTER HEMATOPOIETIC STEM CELL TRANSPLANTATION
por: Pan, Pan, et al.
Publicado: (2023)

FGFR1-Frs2/3 Signalling Maintains Sensory Progenitors during Inner Ear Hair Cell Formation
por: Ono, Kazuya, et al.
Publicado: (2014)

Thrombopoietin and its receptor in normal and neoplastic hematopoiesis
por: Kaushansky, Kenneth
Publicado: (2016)

Thrombopoietin receptor agonists: ten years later
por: Ghanima, Waleed, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_58s4n6a8m0339dmmr86bhri2ij