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Prevalence of Chlamydia trachomatis Among Pregnant Women, Gynecology Clinic Attendees, and Subfertile Women in Guangdong, China: A Cross-sectional Survey
BACKGROUND: Chlamydia trachomatis (CT) is a major cause of infertility and adverse birth outcomes, but its epidemiology among childbearing-age women remains unclear in China. This study investigated the prevalence of CT and associated factors among Chinese women aged 16–44 years who were either (1)...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253043/ https://www.ncbi.nlm.nih.gov/pubmed/34235228 http://dx.doi.org/10.1093/ofid/ofab206 |
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author | Li, Changchang Tang, Weiming Ho, Hung Chak Ong, Jason J Zheng, Xiaojing Sun, Xuewan Li, Xia Liu, Lijun Wang, Yajie Zhao, Peizhen Xiong, Mingzhou Zheng, Heping Wang, Cheng Yang, Bin |
author_facet | Li, Changchang Tang, Weiming Ho, Hung Chak Ong, Jason J Zheng, Xiaojing Sun, Xuewan Li, Xia Liu, Lijun Wang, Yajie Zhao, Peizhen Xiong, Mingzhou Zheng, Heping Wang, Cheng Yang, Bin |
author_sort | Li, Changchang |
collection | PubMed |
description | BACKGROUND: Chlamydia trachomatis (CT) is a major cause of infertility and adverse birth outcomes, but its epidemiology among childbearing-age women remains unclear in China. This study investigated the prevalence of CT and associated factors among Chinese women aged 16–44 years who were either (1) pregnant, (2) attending gynecology clinics, or (3) subfertile. METHODS: We conducted a cross-sectional survey and recruited participants from obstetrics, gynecology, and infertility clinics in Guangdong between March and December 2019. We collected information on individuals’ sociodemographic characteristics, previous medical conditions, and sexual behaviors. First-pass urine and cervical swabs were tested using nucleic acid amplification testing. We calculated the prevalence in each population and subgroup by age, education, and age at first sex. Multivariable binomial regression models were used to identify factors associated with CT. RESULTS: We recruited 881 pregnant women, 595 gynecology clinic attendees, and 254 subfertile women. The prevalence of CT was 6.7% (95% CI, 5.2%–8.5%), 8.2% (95% CI, 6.2%–10.7%), and 5.9% (95% CI, 3.5%–9.3%) for the above 3 populations, respectively. The subgroup-specific prevalence was highest among those who first had sex before age 25 years and older pregnant women (>35 years). The proportion of asymptomatic CT was 84.8%, 40.0%, and 60.0% among pregnant women, gynecology clinic attendees, and subfertile women, respectively. Age at first sex (<25 years), multipara, and ever having more than 1 partner increased the risk of CT. CONCLUSIONS: Childbearing-age women in China have a high prevalence of CT. As most women with CT were asymptomatic, more optimal prevention strategies are urgently needed in China. |
format | Online Article Text |
id | pubmed-8253043 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-82530432021-07-06 Prevalence of Chlamydia trachomatis Among Pregnant Women, Gynecology Clinic Attendees, and Subfertile Women in Guangdong, China: A Cross-sectional Survey Li, Changchang Tang, Weiming Ho, Hung Chak Ong, Jason J Zheng, Xiaojing Sun, Xuewan Li, Xia Liu, Lijun Wang, Yajie Zhao, Peizhen Xiong, Mingzhou Zheng, Heping Wang, Cheng Yang, Bin Open Forum Infect Dis Major Articles BACKGROUND: Chlamydia trachomatis (CT) is a major cause of infertility and adverse birth outcomes, but its epidemiology among childbearing-age women remains unclear in China. This study investigated the prevalence of CT and associated factors among Chinese women aged 16–44 years who were either (1) pregnant, (2) attending gynecology clinics, or (3) subfertile. METHODS: We conducted a cross-sectional survey and recruited participants from obstetrics, gynecology, and infertility clinics in Guangdong between March and December 2019. We collected information on individuals’ sociodemographic characteristics, previous medical conditions, and sexual behaviors. First-pass urine and cervical swabs were tested using nucleic acid amplification testing. We calculated the prevalence in each population and subgroup by age, education, and age at first sex. Multivariable binomial regression models were used to identify factors associated with CT. RESULTS: We recruited 881 pregnant women, 595 gynecology clinic attendees, and 254 subfertile women. The prevalence of CT was 6.7% (95% CI, 5.2%–8.5%), 8.2% (95% CI, 6.2%–10.7%), and 5.9% (95% CI, 3.5%–9.3%) for the above 3 populations, respectively. The subgroup-specific prevalence was highest among those who first had sex before age 25 years and older pregnant women (>35 years). The proportion of asymptomatic CT was 84.8%, 40.0%, and 60.0% among pregnant women, gynecology clinic attendees, and subfertile women, respectively. Age at first sex (<25 years), multipara, and ever having more than 1 partner increased the risk of CT. CONCLUSIONS: Childbearing-age women in China have a high prevalence of CT. As most women with CT were asymptomatic, more optimal prevention strategies are urgently needed in China. Oxford University Press 2021-04-24 /pmc/articles/PMC8253043/ /pubmed/34235228 http://dx.doi.org/10.1093/ofid/ofab206 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Major Articles Li, Changchang Tang, Weiming Ho, Hung Chak Ong, Jason J Zheng, Xiaojing Sun, Xuewan Li, Xia Liu, Lijun Wang, Yajie Zhao, Peizhen Xiong, Mingzhou Zheng, Heping Wang, Cheng Yang, Bin Prevalence of Chlamydia trachomatis Among Pregnant Women, Gynecology Clinic Attendees, and Subfertile Women in Guangdong, China: A Cross-sectional Survey |
title | Prevalence of Chlamydia trachomatis Among Pregnant
Women, Gynecology Clinic Attendees, and Subfertile Women in Guangdong, China: A
Cross-sectional Survey |
title_full | Prevalence of Chlamydia trachomatis Among Pregnant
Women, Gynecology Clinic Attendees, and Subfertile Women in Guangdong, China: A
Cross-sectional Survey |
title_fullStr | Prevalence of Chlamydia trachomatis Among Pregnant
Women, Gynecology Clinic Attendees, and Subfertile Women in Guangdong, China: A
Cross-sectional Survey |
title_full_unstemmed | Prevalence of Chlamydia trachomatis Among Pregnant
Women, Gynecology Clinic Attendees, and Subfertile Women in Guangdong, China: A
Cross-sectional Survey |
title_short | Prevalence of Chlamydia trachomatis Among Pregnant
Women, Gynecology Clinic Attendees, and Subfertile Women in Guangdong, China: A
Cross-sectional Survey |
title_sort | prevalence of chlamydia trachomatis among pregnant
women, gynecology clinic attendees, and subfertile women in guangdong, china: a
cross-sectional survey |
topic | Major Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253043/ https://www.ncbi.nlm.nih.gov/pubmed/34235228 http://dx.doi.org/10.1093/ofid/ofab206 |
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