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Prevalence of Chlamydia trachomatis Among Pregnant Women, Gynecology Clinic Attendees, and Subfertile Women in Guangdong, China: A Cross-sectional Survey

BACKGROUND: Chlamydia trachomatis (CT) is a major cause of infertility and adverse birth outcomes, but its epidemiology among childbearing-age women remains unclear in China. This study investigated the prevalence of CT and associated factors among Chinese women aged 16–44 years who were either (1)...

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Autores principales: Li, Changchang, Tang, Weiming, Ho, Hung Chak, Ong, Jason J, Zheng, Xiaojing, Sun, Xuewan, Li, Xia, Liu, Lijun, Wang, Yajie, Zhao, Peizhen, Xiong, Mingzhou, Zheng, Heping, Wang, Cheng, Yang, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253043/
https://www.ncbi.nlm.nih.gov/pubmed/34235228
http://dx.doi.org/10.1093/ofid/ofab206
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author Li, Changchang
Tang, Weiming
Ho, Hung Chak
Ong, Jason J
Zheng, Xiaojing
Sun, Xuewan
Li, Xia
Liu, Lijun
Wang, Yajie
Zhao, Peizhen
Xiong, Mingzhou
Zheng, Heping
Wang, Cheng
Yang, Bin
author_facet Li, Changchang
Tang, Weiming
Ho, Hung Chak
Ong, Jason J
Zheng, Xiaojing
Sun, Xuewan
Li, Xia
Liu, Lijun
Wang, Yajie
Zhao, Peizhen
Xiong, Mingzhou
Zheng, Heping
Wang, Cheng
Yang, Bin
author_sort Li, Changchang
collection PubMed
description BACKGROUND: Chlamydia trachomatis (CT) is a major cause of infertility and adverse birth outcomes, but its epidemiology among childbearing-age women remains unclear in China. This study investigated the prevalence of CT and associated factors among Chinese women aged 16–44 years who were either (1) pregnant, (2) attending gynecology clinics, or (3) subfertile. METHODS: We conducted a cross-sectional survey and recruited participants from obstetrics, gynecology, and infertility clinics in Guangdong between March and December 2019. We collected information on individuals’ sociodemographic characteristics, previous medical conditions, and sexual behaviors. First-pass urine and cervical swabs were tested using nucleic acid amplification testing. We calculated the prevalence in each population and subgroup by age, education, and age at first sex. Multivariable binomial regression models were used to identify factors associated with CT. RESULTS: We recruited 881 pregnant women, 595 gynecology clinic attendees, and 254 subfertile women. The prevalence of CT was 6.7% (95% CI, 5.2%–8.5%), 8.2% (95% CI, 6.2%–10.7%), and 5.9% (95% CI, 3.5%–9.3%) for the above 3 populations, respectively. The subgroup-specific prevalence was highest among those who first had sex before age 25 years and older pregnant women (>35 years). The proportion of asymptomatic CT was 84.8%, 40.0%, and 60.0% among pregnant women, gynecology clinic attendees, and subfertile women, respectively. Age at first sex (<25 years), multipara, and ever having more than 1 partner increased the risk of CT. CONCLUSIONS: Childbearing-age women in China have a high prevalence of CT. As most women with CT were asymptomatic, more optimal prevention strategies are urgently needed in China.
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spelling pubmed-82530432021-07-06 Prevalence of Chlamydia trachomatis Among Pregnant Women, Gynecology Clinic Attendees, and Subfertile Women in Guangdong, China: A Cross-sectional Survey Li, Changchang Tang, Weiming Ho, Hung Chak Ong, Jason J Zheng, Xiaojing Sun, Xuewan Li, Xia Liu, Lijun Wang, Yajie Zhao, Peizhen Xiong, Mingzhou Zheng, Heping Wang, Cheng Yang, Bin Open Forum Infect Dis Major Articles BACKGROUND: Chlamydia trachomatis (CT) is a major cause of infertility and adverse birth outcomes, but its epidemiology among childbearing-age women remains unclear in China. This study investigated the prevalence of CT and associated factors among Chinese women aged 16–44 years who were either (1) pregnant, (2) attending gynecology clinics, or (3) subfertile. METHODS: We conducted a cross-sectional survey and recruited participants from obstetrics, gynecology, and infertility clinics in Guangdong between March and December 2019. We collected information on individuals’ sociodemographic characteristics, previous medical conditions, and sexual behaviors. First-pass urine and cervical swabs were tested using nucleic acid amplification testing. We calculated the prevalence in each population and subgroup by age, education, and age at first sex. Multivariable binomial regression models were used to identify factors associated with CT. RESULTS: We recruited 881 pregnant women, 595 gynecology clinic attendees, and 254 subfertile women. The prevalence of CT was 6.7% (95% CI, 5.2%–8.5%), 8.2% (95% CI, 6.2%–10.7%), and 5.9% (95% CI, 3.5%–9.3%) for the above 3 populations, respectively. The subgroup-specific prevalence was highest among those who first had sex before age 25 years and older pregnant women (>35 years). The proportion of asymptomatic CT was 84.8%, 40.0%, and 60.0% among pregnant women, gynecology clinic attendees, and subfertile women, respectively. Age at first sex (<25 years), multipara, and ever having more than 1 partner increased the risk of CT. CONCLUSIONS: Childbearing-age women in China have a high prevalence of CT. As most women with CT were asymptomatic, more optimal prevention strategies are urgently needed in China. Oxford University Press 2021-04-24 /pmc/articles/PMC8253043/ /pubmed/34235228 http://dx.doi.org/10.1093/ofid/ofab206 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Major Articles
Li, Changchang
Tang, Weiming
Ho, Hung Chak
Ong, Jason J
Zheng, Xiaojing
Sun, Xuewan
Li, Xia
Liu, Lijun
Wang, Yajie
Zhao, Peizhen
Xiong, Mingzhou
Zheng, Heping
Wang, Cheng
Yang, Bin
Prevalence of Chlamydia trachomatis Among Pregnant Women, Gynecology Clinic Attendees, and Subfertile Women in Guangdong, China: A Cross-sectional Survey
title Prevalence of Chlamydia trachomatis Among Pregnant Women, Gynecology Clinic Attendees, and Subfertile Women in Guangdong, China: A Cross-sectional Survey
title_full Prevalence of Chlamydia trachomatis Among Pregnant Women, Gynecology Clinic Attendees, and Subfertile Women in Guangdong, China: A Cross-sectional Survey
title_fullStr Prevalence of Chlamydia trachomatis Among Pregnant Women, Gynecology Clinic Attendees, and Subfertile Women in Guangdong, China: A Cross-sectional Survey
title_full_unstemmed Prevalence of Chlamydia trachomatis Among Pregnant Women, Gynecology Clinic Attendees, and Subfertile Women in Guangdong, China: A Cross-sectional Survey
title_short Prevalence of Chlamydia trachomatis Among Pregnant Women, Gynecology Clinic Attendees, and Subfertile Women in Guangdong, China: A Cross-sectional Survey
title_sort prevalence of chlamydia trachomatis among pregnant women, gynecology clinic attendees, and subfertile women in guangdong, china: a cross-sectional survey
topic Major Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253043/
https://www.ncbi.nlm.nih.gov/pubmed/34235228
http://dx.doi.org/10.1093/ofid/ofab206
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