Activation of the DDR Pathway Leads to the Down-Regulation of the TGFβ Pathway and a Better Response to ICIs in Patients With Metastatic Urothelial Carcinoma

Immune checkpoint inhibitors (ICIs) have changed the treatment paradigm of metastatic urothelial carcinoma (mUC), a dominant type of bladder cancer (BC). Previous studies have shown an association between gene mutations in the DNA damage response (DDR) pathway and the immunotherapy response in mUC b...

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Detalles Bibliográficos
Autores principales: Zhou, Chaozheng, Lin, Anqi, Cao, Manming, Ding, Weimin, Mou, Weiming, Guo, Ningyi, Chen, Zhenyu, Zhang, Jian, Luo, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253049/
https://www.ncbi.nlm.nih.gov/pubmed/34220801
http://dx.doi.org/10.3389/fimmu.2021.634741

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