OXALIPLATIN INDUCED PULMONARY FIBROSIS: A CASE REPORT

Oxaliplatin is part of the standard chemotherapy regimens for treating colorectal carcinoma. Pulmonary fibrosis is a serious but rare side effect of oxaliplatin treatment, which resulted in patient death in more than half of the reported cases. The precise pathophysiological mechanism of this phenom...

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Autores principales: Pavlović, Mirjana, Šeparović, Robert, Silovski, Tajana, Tečić Vuger, Ana, Jurić, Andreja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sestre Milosrdnice University Hospital and Institute of Clinical Medical Research, Vinogradska cesta c. 29 Zagreb 2020
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253075/
https://www.ncbi.nlm.nih.gov/pubmed/34285449
http://dx.doi.org/10.20471/acc.2020.59.04.25
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author Pavlović, Mirjana
Šeparović, Robert
Silovski, Tajana
Tečić Vuger, Ana
Jurić, Andreja
author_facet Pavlović, Mirjana
Šeparović, Robert
Silovski, Tajana
Tečić Vuger, Ana
Jurić, Andreja
author_sort Pavlović, Mirjana
collection PubMed
description Oxaliplatin is part of the standard chemotherapy regimens for treating colorectal carcinoma. Pulmonary fibrosis is a serious but rare side effect of oxaliplatin treatment, which resulted in patient death in more than half of the reported cases. The precise pathophysiological mechanism of this phenomenon has not been clarified yet. Analysis of the reported cases strongly suggests that early diagnosis and immediate corticosteroid treatment are crucial for better prognosis. Here we report a case of pulmonary fibrosis related to the FOLFOX regimen in a patient with early colorectal carcinoma.
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spelling pubmed-82530752021-07-19 OXALIPLATIN INDUCED PULMONARY FIBROSIS: A CASE REPORT Pavlović, Mirjana Šeparović, Robert Silovski, Tajana Tečić Vuger, Ana Jurić, Andreja Acta Clin Croat Case Reports Oxaliplatin is part of the standard chemotherapy regimens for treating colorectal carcinoma. Pulmonary fibrosis is a serious but rare side effect of oxaliplatin treatment, which resulted in patient death in more than half of the reported cases. The precise pathophysiological mechanism of this phenomenon has not been clarified yet. Analysis of the reported cases strongly suggests that early diagnosis and immediate corticosteroid treatment are crucial for better prognosis. Here we report a case of pulmonary fibrosis related to the FOLFOX regimen in a patient with early colorectal carcinoma. Sestre Milosrdnice University Hospital and Institute of Clinical Medical Research, Vinogradska cesta c. 29 Zagreb 2020-12 /pmc/articles/PMC8253075/ /pubmed/34285449 http://dx.doi.org/10.20471/acc.2020.59.04.25 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (CC BY-NC-ND) 4.0 License.
spellingShingle Case Reports
Pavlović, Mirjana
Šeparović, Robert
Silovski, Tajana
Tečić Vuger, Ana
Jurić, Andreja
OXALIPLATIN INDUCED PULMONARY FIBROSIS: A CASE REPORT
title OXALIPLATIN INDUCED PULMONARY FIBROSIS: A CASE REPORT
title_full OXALIPLATIN INDUCED PULMONARY FIBROSIS: A CASE REPORT
title_fullStr OXALIPLATIN INDUCED PULMONARY FIBROSIS: A CASE REPORT
title_full_unstemmed OXALIPLATIN INDUCED PULMONARY FIBROSIS: A CASE REPORT
title_short OXALIPLATIN INDUCED PULMONARY FIBROSIS: A CASE REPORT
title_sort oxaliplatin induced pulmonary fibrosis: a case report
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253075/
https://www.ncbi.nlm.nih.gov/pubmed/34285449
http://dx.doi.org/10.20471/acc.2020.59.04.25
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